CLEC14A — 81 ClinVar variants
All ClinVar germline CLEC14A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
2 Benign · 2 Likely benign · 77 Uncertain significance
Full CLEC14A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC14A p.Ala140Ser Uncertain significance Single submitter
- CLEC14A p.Ala155Ser Uncertain significance Single submitter
- CLEC14A p.Ala228Gly Uncertain significance Single submitter
- CLEC14A p.Ala308Pro Uncertain significance Single submitter
- CLEC14A p.Ala36Ser Uncertain significance Single submitter
- CLEC14A p.Ala475Val Uncertain significance Single submitter
- CLEC14A p.Ala66Glu Uncertain significance Single submitter
- CLEC14A p.Ala95Ser Uncertain significance Single submitter
- CLEC14A p.Arg2Ser Uncertain significance Single submitter
- CLEC14A p.Asp204His Uncertain significance Single submitter
- CLEC14A p.Asp324Asn Uncertain significance Single submitter
- CLEC14A p.Asp468Asn Uncertain significance Single submitter
- CLEC14A p.Cys103Gly Uncertain significance Single submitter
- CLEC14A p.Cys143Trp Uncertain significance Single submitter
- CLEC14A p.Cys162Tyr Uncertain significance Single submitter
- CLEC14A p.Cys171Arg Uncertain significance Single submitter
- CLEC14A p.Cys179Arg Uncertain significance Single submitter
- CLEC14A p.Cys179Ser Uncertain significance Single submitter
- CLEC14A p.Gln147Arg Uncertain significance Single submitter
- CLEC14A p.Gln147His Uncertain significance Single submitter
- CLEC14A p.Gln48Arg Uncertain significance Single submitter
- CLEC14A p.Gly150Ser Uncertain significance Single submitter
- CLEC14A p.Gly297Glu Uncertain significance Single submitter
- CLEC14A p.Gly59Glu Uncertain significance Single submitter
- CLEC14A p.His42Arg Uncertain significance Single submitter
- CLEC14A p.Ile321Thr Uncertain significance Single submitter
- CLEC14A p.Ile343Val Uncertain significance Single submitter
- CLEC14A p.Ile346Ser Uncertain significance Single submitter
- CLEC14A p.Leu123Val Uncertain significance Single submitter
- CLEC14A p.Leu423Phe Uncertain significance Single submitter
- CLEC14A p.Lys379Glu Uncertain significance Single submitter
- CLEC14A p.Met45Val Uncertain significance Single submitter
- CLEC14A p.Phe175Ser Uncertain significance Single submitter
- CLEC14A p.Pro109Thr Uncertain significance Single submitter
- CLEC14A p.Pro347Leu Uncertain significance Single submitter
- CLEC14A p.Pro372Ala Uncertain significance Single submitter
- CLEC14A p.Pro429Arg Uncertain significance Single submitter
- CLEC14A p.Pro81Ser Uncertain significance Single submitter
- CLEC14A p.Ser32Leu Uncertain significance Single submitter
- CLEC14A p.Thr149Ile Uncertain significance Single submitter
- CLEC14A p.Thr275Lys Uncertain significance Single submitter
- CLEC14A p.Thr63Ala Uncertain significance Single submitter
- CLEC14A p.Trp11Cys Uncertain significance Single submitter
- CLEC14A p.Trp130Cys Uncertain significance Single submitter
- CLEC14A p.Val398Met Uncertain significance Single submitter
- CLEC14A p.Val408Ala Uncertain significance Single submitter
- CLEC14A p.Val466Ile Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- CLEC14A p.Ala186Val Uncertain significance Single submitter
- CLEC14A p.Ala233Val Uncertain significance Single submitter
- CLEC14A p.Ala257Ser Uncertain significance Single submitter
- CLEC14A p.Ala60Pro Uncertain significance Single submitter
- CLEC14A p.Arg100His Uncertain significance Single submitter
- CLEC14A p.Arg234Cys Uncertain significance Single submitter
- CLEC14A p.Arg234Leu Uncertain significance Single submitter
- CLEC14A p.Asp241Val Uncertain significance Single submitter
- CLEC14A p.Cys8Tyr Uncertain significance Single submitter
- CLEC14A p.Glu97Asp Uncertain significance Single submitter
- CLEC14A p.Gly218Arg Uncertain significance Single submitter
- CLEC14A p.Gly232Arg Uncertain significance Single submitter
- CLEC14A p.Gly86Val Uncertain significance Single submitter
- CLEC14A p.His41Gln Uncertain significance Single submitter
- CLEC14A p.His41Tyr Uncertain significance Single submitter
- CLEC14A p.Leu164Pro Uncertain significance Single submitter
- CLEC14A p.Leu198Val Uncertain significance Single submitter
- CLEC14A p.Leu203Val Uncertain significance Single submitter
- CLEC14A p.Leu480Met Uncertain significance Single submitter
- CLEC14A p.Leu91Pro Uncertain significance Single submitter
- CLEC14A p.Pro109His Uncertain significance Single submitter
- CLEC14A p.Pro180Ser Uncertain significance Single submitter
- CLEC14A p.Pro221Leu Uncertain significance Single submitter
- CLEC14A p.Ser117Pro Uncertain significance Single submitter
- CLEC14A p.Ser213Ile Uncertain significance Single submitter
- CLEC14A p.Ser342Phe Uncertain significance Single submitter
- CLEC14A p.Ser385Phe Uncertain significance Single submitter
- CLEC14A p.Ser483Tyr Uncertain significance Single submitter
- CLEC14A p.Thr341Ile Uncertain significance Single submitter
- CLEC14A p.Thr354Met Uncertain significance Single submitter
-
CLEC14A p.Arg305His
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All CLEC14A variants
Benign 2
- p.Ser395= Multiple submitters
- p.Thr275Ala Single submitter
Likely benign 2
- p.Gly17Arg Single submitter
- p.Arg305His No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Uncertain significance 77
- p.Ala140Ser Single submitter ⚠
- p.Ala155Ser Single submitter ⚠
- p.Ala186Val Single submitter ⚠
- p.Ala228Gly Single submitter ⚠
- p.Ala233Val Single submitter ⚠
- p.Ala257Ser Single submitter ⚠
- p.Ala308Pro Single submitter ⚠
- p.Ala36Ser Single submitter ⚠
- p.Ala475Val Single submitter ⚠
- p.Ala60Pro Single submitter ⚠
- p.Ala66Glu Single submitter ⚠
- p.Ala95Ser Single submitter ⚠
- p.Arg100His Single submitter ⚠
- p.Arg234Cys Single submitter ⚠
- p.Arg234Leu Single submitter ⚠
- p.Arg2Ser Single submitter ⚠
- p.Asp204His Single submitter ⚠
- p.Asp241Val Single submitter ⚠
- p.Asp324Asn Single submitter ⚠
- p.Asp468Asn Single submitter ⚠
- p.Cys103Gly Single submitter ⚠
- p.Cys143Trp Single submitter ⚠
- p.Cys162Tyr Single submitter ⚠
- p.Cys171Arg Single submitter ⚠
- p.Cys179Arg Single submitter ⚠
- p.Cys179Ser Single submitter ⚠
- p.Cys8Tyr Single submitter ⚠
- p.Gln147Arg Single submitter ⚠
- p.Gln147His Single submitter ⚠
- p.Gln48Arg Single submitter ⚠
- p.Glu97Asp Single submitter ⚠
- p.Gly150Ser Single submitter ⚠
- p.Gly218Arg Single submitter ⚠
- p.Gly232Arg Single submitter ⚠
- p.Gly297Glu Single submitter ⚠
- p.Gly59Glu Single submitter ⚠
- p.Gly86Val Single submitter ⚠
- p.His41Gln Single submitter ⚠
- p.His41Tyr Single submitter ⚠
- p.His42Arg Single submitter ⚠
- p.Ile321Thr Single submitter ⚠
- p.Ile343Val Single submitter ⚠
- p.Ile346Ser Single submitter ⚠
- p.Leu123Val Single submitter ⚠
- p.Leu164Pro Single submitter ⚠
- p.Leu198Val Single submitter ⚠
- p.Leu203Val Single submitter ⚠
- p.Leu423Phe Single submitter ⚠
- p.Leu480Met Single submitter ⚠
- p.Leu91Pro Single submitter ⚠
- p.Lys379Glu Single submitter ⚠
- p.Met45Val Single submitter ⚠
- p.Phe175Ser Single submitter ⚠
- p.Pro109His Single submitter ⚠
- p.Pro109Thr Single submitter ⚠
- p.Pro180Ser Single submitter ⚠
- p.Pro221Leu Single submitter ⚠
- p.Pro347Leu Single submitter ⚠
- p.Pro372Ala Single submitter ⚠
- p.Pro429Arg Single submitter ⚠
- p.Pro81Ser Single submitter ⚠
- p.Ser117Pro Single submitter ⚠
- p.Ser213Ile Single submitter ⚠
- p.Ser32Leu Single submitter ⚠
- p.Ser342Phe Single submitter ⚠
- p.Ser385Phe Single submitter ⚠
- p.Ser483Tyr Single submitter ⚠
- p.Thr149Ile Single submitter ⚠
- p.Thr275Lys Single submitter ⚠
- p.Thr341Ile Single submitter ⚠
- p.Thr354Met Single submitter ⚠
- p.Thr63Ala Single submitter ⚠
- p.Trp11Cys Single submitter ⚠
- p.Trp130Cys Single submitter ⚠
- p.Val398Met Single submitter ⚠
- p.Val408Ala Single submitter ⚠
- p.Val466Ile Single submitter ⚠