CLEC16A — 169 ClinVar variants
All ClinVar germline CLEC16A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 157 flagged for review →
1 Benign · 2 Benign/Likely benign · 14 Likely benign · 152 Uncertain significance
Full CLEC16A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 157
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 107
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC16A p.Ala1043Val Uncertain significance Single submitter
- CLEC16A p.Ala347Thr Uncertain significance Single submitter
- CLEC16A p.Ala358Val Uncertain significance Single submitter
- CLEC16A p.Ala451Gly Uncertain significance Single submitter
- CLEC16A p.Ala451Thr Uncertain significance Single submitter
- CLEC16A p.Ala560Val Uncertain significance Single submitter
- CLEC16A p.Ala874Val Uncertain significance Single submitter
- CLEC16A p.Ala969Ser Uncertain significance Single submitter
- CLEC16A p.Arg1019Cys Uncertain significance Single submitter
- CLEC16A p.Arg212Pro Uncertain significance Single submitter
- CLEC16A p.Arg363Gln Uncertain significance Single submitter
- CLEC16A p.Arg374Gln Uncertain significance Single submitter
- CLEC16A p.Arg386Gln Uncertain significance Single submitter
- CLEC16A p.Arg443Cys Uncertain significance Single submitter
- CLEC16A p.Arg44Trp Uncertain significance Single submitter
- CLEC16A p.Arg601Gln Uncertain significance Single submitter
- CLEC16A p.Arg664Gln Uncertain significance Single submitter
- CLEC16A p.Arg681Gln Uncertain significance Single submitter
- CLEC16A p.Arg743Met Uncertain significance Single submitter
- CLEC16A p.Arg861Gln Uncertain significance Single submitter
- CLEC16A p.Arg86Gly Uncertain significance Single submitter
- CLEC16A p.Arg870Gly Uncertain significance Single submitter
- CLEC16A p.Asn155Ser Uncertain significance Single submitter
- CLEC16A p.Asn265Ser Uncertain significance Single submitter
- CLEC16A p.Asn771His Uncertain significance Single submitter
- CLEC16A p.Asp277Asn Uncertain significance Single submitter
- CLEC16A p.Asp401Ala Uncertain significance Single submitter
- CLEC16A p.Asp766Asn Uncertain significance Single submitter
- CLEC16A p.Asp865Val Uncertain significance Single submitter
- CLEC16A p.Asp877Glu Uncertain significance Single submitter
- CLEC16A p.Asp936Gly Uncertain significance Single submitter
- CLEC16A p.Gln205Glu Uncertain significance Single submitter
- CLEC16A p.Gln205Pro Uncertain significance Single submitter
- CLEC16A p.Gln351Glu Uncertain significance Single submitter
- CLEC16A p.Gln456His Uncertain significance Single submitter
- CLEC16A p.Gln687Arg Uncertain significance Single submitter
- CLEC16A p.Gln858His Uncertain significance Single submitter
- CLEC16A p.Gln899His Uncertain significance Single submitter
- CLEC16A p.Glu1005Lys Uncertain significance Single submitter
- CLEC16A p.Glu1040Lys Uncertain significance Single submitter
- CLEC16A p.Glu111Lys Uncertain significance Single submitter
- CLEC16A p.Glu531Ala Uncertain significance Single submitter
- CLEC16A p.Glu685Lys Uncertain significance Single submitter
- CLEC16A p.Glu764Val Uncertain significance Single submitter
- CLEC16A p.Glu957Lys Uncertain significance Single submitter
- CLEC16A p.Gly1023Ser Uncertain significance Single submitter
- CLEC16A p.Gly10Ser Uncertain significance Single submitter
- CLEC16A p.Gly303Glu Uncertain significance Single submitter
- CLEC16A p.Gly513Val Uncertain significance Single submitter
- CLEC16A p.Gly843Ser Uncertain significance Single submitter
- CLEC16A p.Gly906Arg Uncertain significance Single submitter
- CLEC16A p.Gly912Arg Uncertain significance Single submitter
- CLEC16A p.Gly920Glu Uncertain significance Single submitter
- CLEC16A p.His1016Gln Uncertain significance Single submitter
- CLEC16A p.His891Tyr Uncertain significance Single submitter
- CLEC16A p.Ile580Val Uncertain significance Single submitter
- CLEC16A p.Ile774Val Uncertain significance Single submitter
- CLEC16A p.Leu101Phe Uncertain significance Single submitter
- CLEC16A p.Leu279Phe Uncertain significance Single submitter
- CLEC16A p.Leu562Pro Uncertain significance Single submitter
- CLEC16A p.Leu567Val Uncertain significance Single submitter
- CLEC16A p.Lys382Glu Uncertain significance Single submitter
- CLEC16A p.Lys75Arg Uncertain significance Single submitter
- CLEC16A p.Lys810Arg Uncertain significance Single submitter
- CLEC16A p.Lys945Asn Uncertain significance Single submitter
- CLEC16A p.Met1024Val Uncertain significance Single submitter
- CLEC16A p.Met185Val Uncertain significance Single submitter
- CLEC16A p.Met441Val Uncertain significance Single submitter
- CLEC16A p.Met575Ile Uncertain significance Single submitter
- CLEC16A p.Met633Ile Uncertain significance Single submitter
- CLEC16A p.Met722Val Uncertain significance Single submitter
- CLEC16A p.Met820Lys Uncertain significance Single submitter
- CLEC16A p.Phe226Ile Uncertain significance Single submitter
- CLEC16A p.Phe321Val Uncertain significance Single submitter
- CLEC16A p.Pro1012Arg Uncertain significance Single submitter
- CLEC16A p.Pro1030Leu Uncertain significance Single submitter
- CLEC16A p.Pro328Thr Uncertain significance Single submitter
- CLEC16A p.Pro553Gln Uncertain significance Single submitter
- CLEC16A p.Pro866Leu Uncertain significance Single submitter
- CLEC16A p.Pro894Leu Uncertain significance Single submitter
- CLEC16A p.Pro894Ser Uncertain significance Single submitter
- CLEC16A p.Pro928Ala Uncertain significance Single submitter
- CLEC16A p.Ser229Asn Uncertain significance Single submitter
- CLEC16A p.Ser444Gly Uncertain significance Single submitter
- CLEC16A p.Ser509Cys Uncertain significance Single submitter
- CLEC16A p.Ser863Gly Uncertain significance Single submitter
- CLEC16A p.Ser892Thr Uncertain significance Single submitter
- CLEC16A p.Ser978Thr Uncertain significance Single submitter
- CLEC16A p.Thr16Ala Uncertain significance Single submitter
- CLEC16A p.Thr429Met Uncertain significance Single submitter
- CLEC16A p.Thr453Pro Uncertain significance Single submitter
- CLEC16A p.Thr561Met Uncertain significance Single submitter
- CLEC16A p.Thr644Met Uncertain significance Single submitter
- CLEC16A p.Thr647Ser Uncertain significance Single submitter
- CLEC16A p.Thr663Pro Uncertain significance Single submitter
- CLEC16A p.Thr834Ile Uncertain significance Single submitter
- CLEC16A p.Thr846Ile Uncertain significance Single submitter
- CLEC16A p.Trp477Arg Uncertain significance Single submitter
- CLEC16A p.Tyr219Ser Uncertain significance Single submitter
- CLEC16A p.Tyr346His Uncertain significance Single submitter
- CLEC16A p.Tyr506Cys Uncertain significance Single submitter
- CLEC16A p.Val1013Ile Uncertain significance Single submitter
- CLEC16A p.Val396Ala Uncertain significance Single submitter
- CLEC16A p.Val396Leu Uncertain significance Single submitter
- CLEC16A p.Val652Met Uncertain significance Single submitter
-
CLEC16A p.Arg305Trp
Uncertain significance
No assertion criteria
Meniere disease
-
CLEC16A p.Pro689Leu
Uncertain significance
No assertion criteria
Meniere disease
Predictors split 50
The independent predictors disagree with each other — read with care.
- CLEC16A p.Leu948Phe Benign Multiple submitters
- CLEC16A p.Ser892Asn Likely benign Multiple submitters
- CLEC16A p.Ser982Asn Likely benign Multiple submitters
- CLEC16A p.Thr475Met Benign/Likely benign Multiple submitters
- CLEC16A p.Ala550Thr Uncertain significance Single submitter
- CLEC16A p.Ala883Thr Uncertain significance Single submitter
- CLEC16A p.Arg18Leu Uncertain significance Single submitter
- CLEC16A p.Arg692Gln Uncertain significance Single submitter
- CLEC16A p.Arg817His Uncertain significance Single submitter
- CLEC16A p.Arg817Leu Uncertain significance Single submitter
- CLEC16A p.Arg854Cys Uncertain significance Single submitter
- CLEC16A p.Arg861Trp Uncertain significance Single submitter
- CLEC16A p.Asn204Lys Uncertain significance Single submitter
- CLEC16A p.Asn271His Uncertain significance Single submitter
- CLEC16A p.Asn45His Uncertain significance Single submitter
- CLEC16A p.Cys1034Tyr Uncertain significance Single submitter
- CLEC16A p.Glu996Lys Uncertain significance Single submitter
- CLEC16A p.His497Arg Uncertain significance Single submitter
- CLEC16A p.Ile667Val Uncertain significance Single submitter
- CLEC16A p.Ile774Met Uncertain significance Single submitter
- CLEC16A p.Leu1018Phe Uncertain significance Single submitter
- CLEC16A p.Leu253Val Uncertain significance Single submitter
- CLEC16A p.Leu489Met Uncertain significance Single submitter
- CLEC16A p.Leu519Ser Uncertain significance Single submitter
- CLEC16A p.Leu562Met Uncertain significance Single submitter
- CLEC16A p.Met672Thr Uncertain significance Single submitter
- CLEC16A p.Met77Thr Uncertain significance Single submitter
- CLEC16A p.Met818Val Uncertain significance Single submitter
- CLEC16A p.Pro1012Gln Uncertain significance Single submitter
- CLEC16A p.Pro1047Ser Uncertain significance Single submitter
- CLEC16A p.Pro928Arg Uncertain significance Single submitter
- CLEC16A p.Ser1028Phe Uncertain significance Single submitter
- CLEC16A p.Ser919Cys Uncertain significance Single submitter
- CLEC16A p.Ser923Arg Uncertain significance Single submitter
- CLEC16A p.Ser924Leu Uncertain significance Single submitter
- CLEC16A p.Ser933Cys Uncertain significance Single submitter
- CLEC16A p.Ser978Asn Likely benign Single submitter
- CLEC16A p.Thr1029Met Uncertain significance Single submitter
- CLEC16A p.Thr371Ile Uncertain significance Single submitter
- CLEC16A p.Thr958Met Uncertain significance Single submitter
- CLEC16A p.Tyr618Cys Uncertain significance Single submitter
- CLEC16A p.Val128Ile Uncertain significance Single submitter
- CLEC16A p.Val32Leu Uncertain significance Single submitter
- CLEC16A p.Val39Ile Uncertain significance Single submitter
- CLEC16A p.Val455Met Uncertain significance Single submitter
-
CLEC16A p.Val501Met
Uncertain significance
Single submitter
Meniere disease
- CLEC16A p.Val763Met Uncertain significance Single submitter
- CLEC16A p.Val872Met Uncertain significance Single submitter
- CLEC16A p.Val884Met Uncertain significance Single submitter
- CLEC16A p.Val95Ile Uncertain significance Single submitter
All CLEC16A variants
Benign 1
- p.Leu948Phe Multiple submitters ⚠
Benign/Likely benign 2
- p.Glu432= Multiple submitters
- p.Thr475Met Multiple submitters ⚠
Likely benign 14
- p.His31= Multiple submitters
- p.Ser892Asn Multiple submitters ⚠
- p.Ser982Asn Multiple submitters ⚠
- p.Ala1051Thr Single submitter
- p.Ala977Val Single submitter
- p.Arg1019His Single submitter
- p.Arg987Gln Single submitter
- p.Glu243= Single submitter
- p.Leu842= Single submitter
- p.Phe500= Single submitter
- p.Pro538Leu Single submitter
- p.Ser978Asn Single submitter ⚠
- p.Thr429= Single submitter
- p.Thr691= Single submitter
Uncertain significance 152
- p.Ala1043Val Single submitter ⚠
- p.Ala347Thr Single submitter ⚠
- p.Ala358Val Single submitter ⚠
- p.Ala451Gly Single submitter ⚠
- p.Ala451Thr Single submitter ⚠
- p.Ala550Thr Single submitter ⚠
- p.Ala560Val Single submitter ⚠
- p.Ala874Val Single submitter ⚠
- p.Ala883Thr Single submitter ⚠
- p.Ala969Ser Single submitter ⚠
- p.Arg1019Cys Single submitter ⚠
- p.Arg18Leu Single submitter ⚠
- p.Arg212Pro Single submitter ⚠
- p.Arg363Gln Single submitter ⚠
- p.Arg374Gln Single submitter ⚠
- p.Arg386Gln Single submitter ⚠
- p.Arg443Cys Single submitter ⚠
- p.Arg44Trp Single submitter ⚠
- p.Arg601Gln Single submitter ⚠
- p.Arg664Gln Single submitter ⚠
- p.Arg681Gln Single submitter ⚠
- p.Arg692Gln Single submitter ⚠
- p.Arg743Met Single submitter ⚠
- p.Arg817His Single submitter ⚠
- p.Arg817Leu Single submitter ⚠
- p.Arg854Cys Single submitter ⚠
- p.Arg861Gln Single submitter ⚠
- p.Arg861Trp Single submitter ⚠
- p.Arg86Gly Single submitter ⚠
- p.Arg870Gly Single submitter ⚠
- p.Asn155Ser Single submitter ⚠
- p.Asn204Lys Single submitter ⚠
- p.Asn265Ser Single submitter ⚠
- p.Asn271His Single submitter ⚠
- p.Asn45His Single submitter ⚠
- p.Asn771His Single submitter ⚠
- p.Asp277Asn Single submitter ⚠
- p.Asp401Ala Single submitter ⚠
- p.Asp766Asn Single submitter ⚠
- p.Asp865Val Single submitter ⚠
- p.Asp877Glu Single submitter ⚠
- p.Asp936Gly Single submitter ⚠
- p.Cys1034Tyr Single submitter ⚠
- p.Gln205Glu Single submitter ⚠
- p.Gln205Pro Single submitter ⚠
- p.Gln351Glu Single submitter ⚠
- p.Gln456His Single submitter ⚠
- p.Gln687Arg Single submitter ⚠
- p.Gln858His Single submitter ⚠
- p.Gln899His Single submitter ⚠
- p.Glu1005Lys Single submitter ⚠
- p.Glu1040Lys Single submitter ⚠
- p.Glu111Lys Single submitter ⚠
- p.Glu531Ala Single submitter ⚠
- p.Glu685Lys Single submitter ⚠
- p.Glu764Val Single submitter ⚠
- p.Glu957Lys Single submitter ⚠
- p.Glu996Lys Single submitter ⚠
- p.Gly1023Ser Single submitter ⚠
- p.Gly10Ser Single submitter ⚠
- p.Gly303Glu Single submitter ⚠
- p.Gly513Val Single submitter ⚠
- p.Gly843Ser Single submitter ⚠
- p.Gly906Arg Single submitter ⚠
- p.Gly912Arg Single submitter ⚠
- p.Gly920Glu Single submitter ⚠
- p.His1016Gln Single submitter ⚠
- p.His497Arg Single submitter ⚠
- p.His891Tyr Single submitter ⚠
- p.Ile580Val Single submitter ⚠
- p.Ile667Val Single submitter ⚠
- p.Ile774Met Single submitter ⚠
- p.Ile774Val Single submitter ⚠
- p.Leu1018Phe Single submitter ⚠
- p.Leu101Phe Single submitter ⚠
- p.Leu253Val Single submitter ⚠
- p.Leu279Phe Single submitter ⚠
- p.Leu489Met Single submitter ⚠
- p.Leu519Ser Single submitter ⚠
- p.Leu562Met Single submitter ⚠
- p.Leu562Pro Single submitter ⚠
- p.Leu567Val Single submitter ⚠
- p.Lys382Glu Single submitter ⚠
- p.Lys75Arg Single submitter ⚠
- p.Lys810Arg Single submitter ⚠
- p.Lys945Asn Single submitter ⚠
- p.Met1024Val Single submitter ⚠
- p.Met185Val Single submitter ⚠
- p.Met441Val Single submitter ⚠
- p.Met575Ile Single submitter ⚠
- p.Met633Ile Single submitter ⚠
- p.Met672Thr Single submitter ⚠
- p.Met722Val Single submitter ⚠
- p.Met77Thr Single submitter ⚠
- p.Met818Val Single submitter ⚠
- p.Met820Lys Single submitter ⚠
- p.Phe226Ile Single submitter ⚠
- p.Phe321Val Single submitter ⚠
- p.Pro1012Arg Single submitter ⚠
- p.Pro1012Gln Single submitter ⚠
- p.Pro1030Leu Single submitter ⚠
- p.Pro1047Ser Single submitter ⚠
- p.Pro328Thr Single submitter ⚠
- p.Pro553Gln Single submitter ⚠
- p.Pro866Leu Single submitter ⚠
- p.Pro894Leu Single submitter ⚠
- p.Pro894Ser Single submitter ⚠
- p.Pro928Ala Single submitter ⚠
- p.Pro928Arg Single submitter ⚠
- p.Ser1028Phe Single submitter ⚠
- p.Ser229Asn Single submitter ⚠
- p.Ser444Gly Single submitter ⚠
- p.Ser509Cys Single submitter ⚠
- p.Ser863Gly Single submitter ⚠
- p.Ser892Thr Single submitter ⚠
- p.Ser919Cys Single submitter ⚠
- p.Ser923Arg Single submitter ⚠
- p.Ser924Leu Single submitter ⚠
- p.Ser933Cys Single submitter ⚠
- p.Ser978Thr Single submitter ⚠
- p.Thr1029Met Single submitter ⚠
- p.Thr16Ala Single submitter ⚠
- p.Thr371Ile Single submitter ⚠
- p.Thr429Met Single submitter ⚠
- p.Thr453Pro Single submitter ⚠
- p.Thr561Met Single submitter ⚠
- p.Thr644Met Single submitter ⚠
- p.Thr647Ser Single submitter ⚠
- p.Thr663Pro Single submitter ⚠
- p.Thr834Ile Single submitter ⚠
- p.Thr846Ile Single submitter ⚠
- p.Thr958Met Single submitter ⚠
- p.Trp477Arg Single submitter ⚠
- p.Tyr219Ser Single submitter ⚠
- p.Tyr346His Single submitter ⚠
- p.Tyr506Cys Single submitter ⚠
- p.Tyr618Cys Single submitter ⚠
- p.Val1013Ile Single submitter ⚠
- p.Val128Ile Single submitter ⚠
- p.Val32Leu Single submitter ⚠
- p.Val396Ala Single submitter ⚠
- p.Val396Leu Single submitter ⚠
- p.Val39Ile Single submitter ⚠
- p.Val455Met Single submitter ⚠
- p.Val501Met Single submitter Meniere disease ⚠
- p.Val652Met Single submitter ⚠
- p.Val763Met Single submitter ⚠
- p.Val872Met Single submitter ⚠
- p.Val884Met Single submitter ⚠
- p.Val95Ile Single submitter ⚠
- p.Arg305Trp No assertion criteria Meniere disease ⚠
- p.Pro689Leu No assertion criteria Meniere disease ⚠