CLEC17A — 45 ClinVar variants
All ClinVar germline CLEC17A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
6 Likely benign · 39 Uncertain significance
Full CLEC17A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC17A p.Ala319Thr Uncertain significance Single submitter
- CLEC17A p.Arg250Cys Uncertain significance Single submitter
- CLEC17A p.Arg250His Uncertain significance Single submitter
- CLEC17A p.Arg250Pro Uncertain significance Single submitter
- CLEC17A p.Arg279Trp Uncertain significance Single submitter
- CLEC17A p.Asn137Lys Uncertain significance Single submitter
- CLEC17A p.Asn3Asp Uncertain significance Single submitter
- CLEC17A p.Asp123Gly Uncertain significance Single submitter
- CLEC17A p.Cys114Phe Uncertain significance Single submitter
- CLEC17A p.Glu200Gln Uncertain significance Single submitter
- CLEC17A p.Glu262Asp Uncertain significance Single submitter
- CLEC17A p.Glu277Gly Uncertain significance Single submitter
- CLEC17A p.His305Asp Uncertain significance Single submitter
- CLEC17A p.Leu147Val Uncertain significance Single submitter
- CLEC17A p.Met170Leu Uncertain significance Single submitter
- CLEC17A p.Met204Thr Uncertain significance Single submitter
- CLEC17A p.Ser95Ile Uncertain significance Single submitter
- CLEC17A p.Thr368Met Uncertain significance Single submitter
- CLEC17A p.Trp258Ser Uncertain significance Single submitter
- CLEC17A p.Val127Phe Uncertain significance Single submitter
- CLEC17A p.Val232Leu Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CLEC17A p.Arg158Met Uncertain significance Single submitter
- CLEC17A p.Arg318Gly Uncertain significance Single submitter
- CLEC17A p.Arg374Gln Uncertain significance Single submitter
- CLEC17A p.Asp228Asn Uncertain significance Single submitter
- CLEC17A p.Asp49Glu Uncertain significance Single submitter
- CLEC17A p.Glu48Asp Likely benign Single submitter
- CLEC17A p.Glu74Asp Likely benign Single submitter
- CLEC17A p.Glu74Lys Uncertain significance Single submitter
- CLEC17A p.Glu79Lys Uncertain significance Single submitter
- CLEC17A p.Gly245Cys Uncertain significance Single submitter
- CLEC17A p.Gly257Ala Uncertain significance Single submitter
- CLEC17A p.Leu155Phe Uncertain significance Single submitter
- CLEC17A p.Leu62Ile Uncertain significance Single submitter
- CLEC17A p.Leu62Phe Uncertain significance Single submitter
- CLEC17A p.Lys264Arg Uncertain significance Single submitter
- CLEC17A p.Met43Ile Uncertain significance Single submitter
- CLEC17A p.Pro116Thr Uncertain significance Single submitter
- CLEC17A p.Pro84Ala Uncertain significance Single submitter
- CLEC17A p.Thr30Ile Uncertain significance Single submitter
- CLEC17A p.Tyr78Cys Uncertain significance Single submitter
All CLEC17A variants
Likely benign 6
- p.Asn156Ser Single submitter
- p.Asp347Asn Single submitter
- p.Glu48Asp Single submitter ⚠
- p.Glu74Asp Single submitter ⚠
- p.Pro13Leu Single submitter
- p.Ser271Ile Single submitter
Uncertain significance 39
- p.Ala319Thr Single submitter ⚠
- p.Arg158Met Single submitter ⚠
- p.Arg250Cys Single submitter ⚠
- p.Arg250His Single submitter ⚠
- p.Arg250Pro Single submitter ⚠
- p.Arg279Trp Single submitter ⚠
- p.Arg318Gly Single submitter ⚠
- p.Arg374Gln Single submitter ⚠
- p.Asn137Lys Single submitter ⚠
- p.Asn3Asp Single submitter ⚠
- p.Asp123Gly Single submitter ⚠
- p.Asp228Asn Single submitter ⚠
- p.Asp49Glu Single submitter ⚠
- p.Cys114Phe Single submitter ⚠
- p.Glu200Gln Single submitter ⚠
- p.Glu262Asp Single submitter ⚠
- p.Glu277Gly Single submitter ⚠
- p.Glu74Lys Single submitter ⚠
- p.Glu79Lys Single submitter ⚠
- p.Gly245Cys Single submitter ⚠
- p.Gly257Ala Single submitter ⚠
- p.His305Asp Single submitter ⚠
- p.Leu147Val Single submitter ⚠
- p.Leu155Phe Single submitter ⚠
- p.Leu62Ile Single submitter ⚠
- p.Leu62Phe Single submitter ⚠
- p.Lys264Arg Single submitter ⚠
- p.Met170Leu Single submitter ⚠
- p.Met204Thr Single submitter ⚠
- p.Met43Ile Single submitter ⚠
- p.Pro116Thr Single submitter ⚠
- p.Pro84Ala Single submitter ⚠
- p.Ser95Ile Single submitter ⚠
- p.Thr30Ile Single submitter ⚠
- p.Thr368Met Single submitter ⚠
- p.Trp258Ser Single submitter ⚠
- p.Tyr78Cys Single submitter ⚠
- p.Val127Phe Single submitter ⚠
- p.Val232Leu Single submitter ⚠