CLEC18A — 68 ClinVar variants
All ClinVar germline CLEC18A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
4 Likely benign · 64 Uncertain significance
Full CLEC18A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC18A p.Ala137Val Uncertain significance Single submitter
- CLEC18A p.Ala19Ser Uncertain significance Single submitter
- CLEC18A p.Ala19Val Uncertain significance Single submitter
- CLEC18A p.Ala24Val Uncertain significance Single submitter
- CLEC18A p.Ala37Ser Uncertain significance Single submitter
- CLEC18A p.Ala37Val Uncertain significance Single submitter
- CLEC18A p.Arg10Pro Uncertain significance Single submitter
- CLEC18A p.Arg423Pro Uncertain significance Single submitter
- CLEC18A p.Arg57His Uncertain significance Single submitter
- CLEC18A p.Arg57Leu Uncertain significance Single submitter
- CLEC18A p.Arg57Ser Uncertain significance Single submitter
- CLEC18A p.Asp421His Uncertain significance Single submitter
- CLEC18A p.Asp73Tyr Uncertain significance Single submitter
- CLEC18A p.Gln111Lys Uncertain significance Single submitter
- CLEC18A p.Gln132Glu Uncertain significance Single submitter
- CLEC18A p.Gln36Pro Uncertain significance Single submitter
- CLEC18A p.Glu140Val Uncertain significance Single submitter
- CLEC18A p.Glu27Asp Uncertain significance Single submitter
- CLEC18A p.Gly22Ala Uncertain significance Single submitter
- CLEC18A p.His149Asp Uncertain significance Single submitter
- CLEC18A p.Pro92Leu Uncertain significance Single submitter
- CLEC18A p.Ser7Ala Uncertain significance Single submitter
- CLEC18A p.Thr148Ala Uncertain significance Single submitter
- CLEC18A p.Trp127Cys Uncertain significance Single submitter
- CLEC18A p.Trp29Leu Uncertain significance Single submitter
- CLEC18A p.Val28Leu Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- CLEC18A p.Ala115Val Uncertain significance Single submitter
- CLEC18A p.Ala142Val Uncertain significance Single submitter
- CLEC18A p.Ala145Thr Uncertain significance Single submitter
- CLEC18A p.Ala416Thr Uncertain significance Single submitter
- CLEC18A p.Ala66Val Uncertain significance Single submitter
- CLEC18A p.Ala67Gly Uncertain significance Single submitter
- CLEC18A p.Ala86Glu Uncertain significance Single submitter
- CLEC18A p.Arg427Gln Uncertain significance Single submitter
- CLEC18A p.Arg57Cys Uncertain significance Single submitter
- CLEC18A p.Arg59His Uncertain significance Single submitter
- CLEC18A p.Arg71Ser Uncertain significance Single submitter
- CLEC18A p.Arg85Lys Uncertain significance Single submitter
- CLEC18A p.Asn144Ile Uncertain significance Single submitter
- CLEC18A p.Cys89Tyr Uncertain significance Single submitter
- CLEC18A p.Gln433Arg Uncertain significance Single submitter
- CLEC18A p.Glu122Lys Uncertain significance Single submitter
- CLEC18A p.Glu47Gly Uncertain significance Single submitter
- CLEC18A p.Gly139Val Uncertain significance Single submitter
- CLEC18A p.His12Tyr Uncertain significance Single submitter
- CLEC18A p.His438Pro Uncertain significance Single submitter
- CLEC18A p.Ile431Leu Uncertain significance Single submitter
- CLEC18A p.Leu113Pro Uncertain significance Single submitter
- CLEC18A p.Leu126Pro Uncertain significance Single submitter
- CLEC18A p.Leu126Val Uncertain significance Single submitter
- CLEC18A p.Leu14Pro Uncertain significance Single submitter
- CLEC18A p.Leu17His Uncertain significance Single submitter
- CLEC18A p.Leu17Phe Uncertain significance Single submitter
- CLEC18A p.Leu33Met Uncertain significance Single submitter
- CLEC18A p.Met69Ile Uncertain significance Single submitter
- CLEC18A p.Pro114Arg Uncertain significance Single submitter
- CLEC18A p.Pro64Ala Uncertain significance Single submitter
- CLEC18A p.Pro65Ser Uncertain significance Single submitter
- CLEC18A p.Pro94Leu Uncertain significance Single submitter
- CLEC18A p.Thr103Ile Uncertain significance Single submitter
- CLEC18A p.Val106Ala Uncertain significance Single submitter
- CLEC18A p.Val123Gly Uncertain significance Single submitter
- CLEC18A p.Val28Met Uncertain significance Single submitter
- CLEC18A p.Val409Met Uncertain significance Single submitter
All CLEC18A variants
Likely benign 4
- p.Ala174Val Single submitter
- p.Arg133Gln Single submitter
- p.Arg185Gly Single submitter
- p.Gly41Arg Single submitter
Uncertain significance 64
- p.Ala115Val Single submitter ⚠
- p.Ala137Val Single submitter ⚠
- p.Ala142Val Single submitter ⚠
- p.Ala145Thr Single submitter ⚠
- p.Ala19Ser Single submitter ⚠
- p.Ala19Val Single submitter ⚠
- p.Ala24Val Single submitter ⚠
- p.Ala37Ser Single submitter ⚠
- p.Ala37Val Single submitter ⚠
- p.Ala416Thr Single submitter ⚠
- p.Ala66Val Single submitter ⚠
- p.Ala67Gly Single submitter ⚠
- p.Ala86Glu Single submitter ⚠
- p.Arg10Pro Single submitter ⚠
- p.Arg423Pro Single submitter ⚠
- p.Arg427Gln Single submitter ⚠
- p.Arg57Cys Single submitter ⚠
- p.Arg57His Single submitter ⚠
- p.Arg57Leu Single submitter ⚠
- p.Arg57Ser Single submitter ⚠
- p.Arg59His Single submitter ⚠
- p.Arg71Ser Single submitter ⚠
- p.Arg85Lys Single submitter ⚠
- p.Asn144Ile Single submitter ⚠
- p.Asp421His Single submitter ⚠
- p.Asp73Tyr Single submitter ⚠
- p.Cys89Tyr Single submitter ⚠
- p.Gln111Lys Single submitter ⚠
- p.Gln132Glu Single submitter ⚠
- p.Gln36Pro Single submitter ⚠
- p.Gln433Arg Single submitter ⚠
- p.Glu122Lys Single submitter ⚠
- p.Glu140Val Single submitter ⚠
- p.Glu27Asp Single submitter ⚠
- p.Glu47Gly Single submitter ⚠
- p.Gly139Val Single submitter ⚠
- p.Gly22Ala Single submitter ⚠
- p.His12Tyr Single submitter ⚠
- p.His149Asp Single submitter ⚠
- p.His438Pro Single submitter ⚠
- p.Ile431Leu Single submitter ⚠
- p.Leu113Pro Single submitter ⚠
- p.Leu126Pro Single submitter ⚠
- p.Leu126Val Single submitter ⚠
- p.Leu14Pro Single submitter ⚠
- p.Leu17His Single submitter ⚠
- p.Leu17Phe Single submitter ⚠
- p.Leu33Met Single submitter ⚠
- p.Met69Ile Single submitter ⚠
- p.Pro114Arg Single submitter ⚠
- p.Pro64Ala Single submitter ⚠
- p.Pro65Ser Single submitter ⚠
- p.Pro92Leu Single submitter ⚠
- p.Pro94Leu Single submitter ⚠
- p.Ser7Ala Single submitter ⚠
- p.Thr103Ile Single submitter ⚠
- p.Thr148Ala Single submitter ⚠
- p.Trp127Cys Single submitter ⚠
- p.Trp29Leu Single submitter ⚠
- p.Val106Ala Single submitter ⚠
- p.Val123Gly Single submitter ⚠
- p.Val28Leu Single submitter ⚠
- p.Val28Met Single submitter ⚠
- p.Val409Met Single submitter ⚠