CLEC18B — 70 ClinVar variants
All ClinVar germline CLEC18B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
11 Likely benign · 59 Uncertain significance
Full CLEC18B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC18B p.Ala137Ser Uncertain significance Single submitter
- CLEC18B p.Ala137Thr Uncertain significance Single submitter
- CLEC18B p.Ala137Val Uncertain significance Single submitter
- CLEC18B p.Ala202Val Uncertain significance Single submitter
- CLEC18B p.Ala66Glu Uncertain significance Single submitter
- CLEC18B p.Ala84Thr Uncertain significance Single submitter
- CLEC18B p.Ala97Val Uncertain significance Single submitter
- CLEC18B p.Arg10Trp Uncertain significance Single submitter
- CLEC18B p.Arg274Gln Uncertain significance Single submitter
- CLEC18B p.Arg352His Uncertain significance Single submitter
- CLEC18B p.Arg57His Uncertain significance Single submitter
- CLEC18B p.Arg59His Uncertain significance Single submitter
- CLEC18B p.Asn357Thr Uncertain significance Single submitter
- CLEC18B p.Asp421Ala Uncertain significance Single submitter
- CLEC18B p.Cys141Arg Uncertain significance Single submitter
- CLEC18B p.Cys147Arg Uncertain significance Single submitter
- CLEC18B p.Cys207Tyr Uncertain significance Single submitter
- CLEC18B p.Cys225Tyr Uncertain significance Single submitter
- CLEC18B p.Cys280Tyr Uncertain significance Single submitter
- CLEC18B p.Gln436Arg Uncertain significance Single submitter
- CLEC18B p.Gly107Cys Uncertain significance Single submitter
- CLEC18B p.Gly257Asp Uncertain significance Single submitter
- CLEC18B p.His239Arg Uncertain significance Single submitter
- CLEC18B p.His3Pro Uncertain significance Single submitter
- CLEC18B p.Ile195Val Uncertain significance Single submitter
- CLEC18B p.Met110Thr Uncertain significance Single submitter
- CLEC18B p.Met39Thr Uncertain significance Single submitter
- CLEC18B p.Met69Thr Uncertain significance Single submitter
- CLEC18B p.Ser7Pro Uncertain significance Single submitter
- CLEC18B p.Thr256Met Uncertain significance Single submitter
- CLEC18B p.Tyr198Cys Uncertain significance Single submitter
- CLEC18B p.Val281Ile Uncertain significance Single submitter
- CLEC18B p.Val295Leu Uncertain significance Single submitter
- CLEC18B p.Val333Leu Uncertain significance Single submitter
- CLEC18B p.Val342Ala Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CLEC18B c.1212-212G>T Uncertain significance Single submitter
- CLEC18B p.Ala115Val Uncertain significance Single submitter
- CLEC18B p.Ala19Asp Uncertain significance Single submitter
- CLEC18B p.Ala87Thr Uncertain significance Single submitter
- CLEC18B p.Arg241Cys Uncertain significance Single submitter
- CLEC18B p.Arg263Ser Uncertain significance Single submitter
- CLEC18B p.Arg427Gly Uncertain significance Single submitter
- CLEC18B p.Arg429Cys Uncertain significance Single submitter
- CLEC18B p.Arg441Trp Likely benign Single submitter
- CLEC18B p.Arg57Cys Uncertain significance Single submitter
- CLEC18B p.Asn144His Uncertain significance Single submitter
- CLEC18B p.Asn402Lys Uncertain significance Single submitter
- CLEC18B p.Gly271Ser Uncertain significance Single submitter
- CLEC18B p.Gly285Ser Uncertain significance Single submitter
- CLEC18B p.His3Tyr Uncertain significance Single submitter
- CLEC18B p.Leu21His Uncertain significance Single submitter
- CLEC18B p.Pro94Leu Uncertain significance Single submitter
- CLEC18B p.Ser159Gly Uncertain significance Single submitter
- CLEC18B p.Ser183Cys Uncertain significance Single submitter
- CLEC18B p.Ser98Phe Uncertain significance Single submitter
- CLEC18B p.Thr6Asn Uncertain significance Single submitter
- CLEC18B p.Val123Leu Uncertain significance Single submitter
- CLEC18B p.Val123Met Uncertain significance Single submitter
- CLEC18B p.Val28Met Uncertain significance Single submitter
- CLEC18B p.Val62Ile Uncertain significance Single submitter
All CLEC18B variants
Likely benign 11
- p.Ala118Val Single submitter
- p.Ala37Val Single submitter
- p.Arg102His Single submitter
- p.Arg133Gln Single submitter
- p.Arg441Trp Single submitter ⚠
- p.Arg70Gln Single submitter
- p.Gly41Arg Single submitter
- p.Gly443Asp Single submitter
- p.Ile284Val Single submitter
- p.Ile306= Single submitter
- p.Leu20= Single submitter
Uncertain significance 59
- c.1212-212G>T Single submitter ⚠
- p.Ala115Val Single submitter ⚠
- p.Ala137Ser Single submitter ⚠
- p.Ala137Thr Single submitter ⚠
- p.Ala137Val Single submitter ⚠
- p.Ala19Asp Single submitter ⚠
- p.Ala202Val Single submitter ⚠
- p.Ala66Glu Single submitter ⚠
- p.Ala84Thr Single submitter ⚠
- p.Ala87Thr Single submitter ⚠
- p.Ala97Val Single submitter ⚠
- p.Arg10Trp Single submitter ⚠
- p.Arg241Cys Single submitter ⚠
- p.Arg263Ser Single submitter ⚠
- p.Arg274Gln Single submitter ⚠
- p.Arg352His Single submitter ⚠
- p.Arg427Gly Single submitter ⚠
- p.Arg429Cys Single submitter ⚠
- p.Arg57Cys Single submitter ⚠
- p.Arg57His Single submitter ⚠
- p.Arg59His Single submitter ⚠
- p.Asn144His Single submitter ⚠
- p.Asn357Thr Single submitter ⚠
- p.Asn402Lys Single submitter ⚠
- p.Asp421Ala Single submitter ⚠
- p.Cys141Arg Single submitter ⚠
- p.Cys147Arg Single submitter ⚠
- p.Cys207Tyr Single submitter ⚠
- p.Cys225Tyr Single submitter ⚠
- p.Cys280Tyr Single submitter ⚠
- p.Gln436Arg Single submitter ⚠
- p.Gly107Cys Single submitter ⚠
- p.Gly257Asp Single submitter ⚠
- p.Gly271Ser Single submitter ⚠
- p.Gly285Ser Single submitter ⚠
- p.His239Arg Single submitter ⚠
- p.His3Pro Single submitter ⚠
- p.His3Tyr Single submitter ⚠
- p.Ile195Val Single submitter ⚠
- p.Leu21His Single submitter ⚠
- p.Met110Thr Single submitter ⚠
- p.Met39Thr Single submitter ⚠
- p.Met69Thr Single submitter ⚠
- p.Pro94Leu Single submitter ⚠
- p.Ser159Gly Single submitter ⚠
- p.Ser183Cys Single submitter ⚠
- p.Ser7Pro Single submitter ⚠
- p.Ser98Phe Single submitter ⚠
- p.Thr256Met Single submitter ⚠
- p.Thr6Asn Single submitter ⚠
- p.Tyr198Cys Single submitter ⚠
- p.Val123Leu Single submitter ⚠
- p.Val123Met Single submitter ⚠
- p.Val281Ile Single submitter ⚠
- p.Val28Met Single submitter ⚠
- p.Val295Leu Single submitter ⚠
- p.Val333Leu Single submitter ⚠
- p.Val342Ala Single submitter ⚠
- p.Val62Ile Single submitter ⚠