CLEC18C — 42 ClinVar variants
All ClinVar germline CLEC18C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
6 Likely benign · 36 Uncertain significance
Full CLEC18C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC18C p.Ala137Gly Uncertain significance Single submitter
- CLEC18C p.Ala145Thr Uncertain significance Single submitter
- CLEC18C p.Ala40Thr Uncertain significance Single submitter
- CLEC18C p.Ala413Ser Uncertain significance Single submitter
- CLEC18C p.Ala66Glu Uncertain significance Single submitter
- CLEC18C p.Ala84Thr Uncertain significance Single submitter
- CLEC18C p.Arg429His Uncertain significance Single submitter
- CLEC18C p.Arg441Gln Uncertain significance Single submitter
- CLEC18C p.Arg57Leu Uncertain significance Single submitter
- CLEC18C p.Arg57Ser Uncertain significance Single submitter
- CLEC18C p.Asn418Ser Uncertain significance Single submitter
- CLEC18C p.Gln111Glu Uncertain significance Single submitter
- CLEC18C p.Gln36Glu Uncertain significance Single submitter
- CLEC18C p.Gln80Lys Uncertain significance Single submitter
- CLEC18C p.Gly445Arg Uncertain significance Single submitter
- CLEC18C p.Gly99Ser Uncertain significance Single submitter
- CLEC18C p.His438Asp Uncertain significance Single submitter
- CLEC18C p.Leu2Pro Uncertain significance Single submitter
- CLEC18C p.Thr103Ala Uncertain significance Single submitter
- CLEC18C p.Thr146Ser Uncertain significance Single submitter
- CLEC18C p.Thr93Ile Uncertain significance Single submitter
- CLEC18C p.Val28Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CLEC18C p.Arg102Cys Uncertain significance Single submitter
- CLEC18C p.Arg143Cys Uncertain significance Single submitter
- CLEC18C p.Arg57Cys Uncertain significance Single submitter
- CLEC18C p.Arg59His Uncertain significance Single submitter
- CLEC18C p.Gln83Pro Uncertain significance Single submitter
- CLEC18C p.His12Tyr Uncertain significance Single submitter
- CLEC18C p.Pro114Ser Uncertain significance Single submitter
- CLEC18C p.Pro64His Uncertain significance Single submitter
- CLEC18C p.Pro94Thr Uncertain significance Single submitter
- CLEC18C p.Ser440Phe Uncertain significance Single submitter
- CLEC18C p.Ser60Ile Uncertain significance Single submitter
- CLEC18C p.Ser7Tyr Uncertain significance Single submitter
- CLEC18C p.Trp442Arg Uncertain significance Single submitter
- CLEC18C p.Val409Met Uncertain significance Single submitter
All CLEC18C variants
Likely benign 6
- p.Arg102His Single submitter
- p.Arg133Trp Single submitter
- p.Arg185Gly Single submitter
- p.Arg70Gln Single submitter
- p.Gly41Arg Single submitter
- p.Pro38Leu Single submitter
Uncertain significance 36
- p.Ala137Gly Single submitter ⚠
- p.Ala145Thr Single submitter ⚠
- p.Ala40Thr Single submitter ⚠
- p.Ala413Ser Single submitter ⚠
- p.Ala66Glu Single submitter ⚠
- p.Ala84Thr Single submitter ⚠
- p.Arg102Cys Single submitter ⚠
- p.Arg143Cys Single submitter ⚠
- p.Arg429His Single submitter ⚠
- p.Arg441Gln Single submitter ⚠
- p.Arg57Cys Single submitter ⚠
- p.Arg57Leu Single submitter ⚠
- p.Arg57Ser Single submitter ⚠
- p.Arg59His Single submitter ⚠
- p.Asn418Ser Single submitter ⚠
- p.Gln111Glu Single submitter ⚠
- p.Gln36Glu Single submitter ⚠
- p.Gln80Lys Single submitter ⚠
- p.Gln83Pro Single submitter ⚠
- p.Gly445Arg Single submitter ⚠
- p.Gly99Ser Single submitter ⚠
- p.His12Tyr Single submitter ⚠
- p.His438Asp Single submitter ⚠
- p.Leu2Pro Single submitter ⚠
- p.Pro114Ser Single submitter ⚠
- p.Pro64His Single submitter ⚠
- p.Pro94Thr Single submitter ⚠
- p.Ser440Phe Single submitter ⚠
- p.Ser60Ile Single submitter ⚠
- p.Ser7Tyr Single submitter ⚠
- p.Thr103Ala Single submitter ⚠
- p.Thr146Ser Single submitter ⚠
- p.Thr93Ile Single submitter ⚠
- p.Trp442Arg Single submitter ⚠
- p.Val28Leu Single submitter ⚠
- p.Val409Met Single submitter ⚠