CLEC1A — 41 ClinVar variants
All ClinVar germline CLEC1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Benign · 9 Likely benign · 31 Uncertain significance
Full CLEC1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC1A p.Arg254His Uncertain significance Single submitter
- CLEC1A p.Asp10Glu Uncertain significance Single submitter
- CLEC1A p.Asp10Tyr Uncertain significance Single submitter
- CLEC1A p.Asp17Gly Uncertain significance Single submitter
- CLEC1A p.Cys236Arg Uncertain significance Single submitter
- CLEC1A p.Gln150Lys Uncertain significance Single submitter
- CLEC1A p.Glu90Gln Uncertain significance Single submitter
- CLEC1A p.Gly82Cys Uncertain significance Single submitter
- CLEC1A p.His223Arg Uncertain significance Single submitter
- CLEC1A p.Ile86Val Uncertain significance Single submitter
- CLEC1A p.Met11Ile Uncertain significance Single submitter
- CLEC1A p.Met20Thr Uncertain significance Single submitter
- CLEC1A p.Phe192Ile Uncertain significance Single submitter
- CLEC1A p.Pro216Ser Uncertain significance Single submitter
- CLEC1A p.Thr18Ala Uncertain significance Single submitter
- CLEC1A p.Tyr126His Uncertain significance Single submitter
- CLEC1A p.Val60Leu Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CLEC1A p.Ala261Val Uncertain significance Single submitter
- CLEC1A p.Arg31Trp Uncertain significance Single submitter
- CLEC1A p.Arg36Trp Uncertain significance Single submitter
- CLEC1A p.Asp17Tyr Uncertain significance Single submitter
- CLEC1A p.Cys161Ser Uncertain significance Single submitter
- CLEC1A p.Gly206Val Uncertain significance Single submitter
- CLEC1A p.Leu52Pro Uncertain significance Single submitter
- CLEC1A p.Leu57Phe Uncertain significance Single submitter
- CLEC1A p.Phe183Leu Uncertain significance Single submitter
- CLEC1A p.Ser102Cys Uncertain significance Single submitter
- CLEC1A p.Ser6Gly Uncertain significance Single submitter
- CLEC1A p.Thr215Ala Likely benign Single submitter
- CLEC1A p.Thr218Ala Likely benign Single submitter
- CLEC1A p.Tyr196Cys Uncertain significance Single submitter
- CLEC1A p.Tyr75Cys Uncertain significance Single submitter
- CLEC1A p.Val60Met Uncertain significance Single submitter
All CLEC1A variants
Benign 1
- p.Gly26Ala Multiple submitters aspergillosis, susceptibility to
Likely benign 9
- p.His32Arg Multiple submitters
- p.Ala238Thr Single submitter
- p.Ala42Thr Single submitter
- p.Arg31Gln Single submitter
- p.Asp154Glu Single submitter
- p.Leu276Ser Single submitter
- p.Pro231Leu Single submitter
- p.Thr215Ala Single submitter ⚠
- p.Thr218Ala Single submitter ⚠
Uncertain significance 31
- p.Ala261Val Single submitter ⚠
- p.Arg254His Single submitter ⚠
- p.Arg31Trp Single submitter ⚠
- p.Arg36Trp Single submitter ⚠
- p.Asp10Glu Single submitter ⚠
- p.Asp10Tyr Single submitter ⚠
- p.Asp17Gly Single submitter ⚠
- p.Asp17Tyr Single submitter ⚠
- p.Cys161Ser Single submitter ⚠
- p.Cys236Arg Single submitter ⚠
- p.Gln150Lys Single submitter ⚠
- p.Glu90Gln Single submitter ⚠
- p.Gly206Val Single submitter ⚠
- p.Gly82Cys Single submitter ⚠
- p.His223Arg Single submitter ⚠
- p.Ile86Val Single submitter ⚠
- p.Leu52Pro Single submitter ⚠
- p.Leu57Phe Single submitter ⚠
- p.Met11Ile Single submitter ⚠
- p.Met20Thr Single submitter ⚠
- p.Phe183Leu Single submitter ⚠
- p.Phe192Ile Single submitter ⚠
- p.Pro216Ser Single submitter ⚠
- p.Ser102Cys Single submitter ⚠
- p.Ser6Gly Single submitter ⚠
- p.Thr18Ala Single submitter ⚠
- p.Tyr126His Single submitter ⚠
- p.Tyr196Cys Single submitter ⚠
- p.Tyr75Cys Single submitter ⚠
- p.Val60Leu Single submitter ⚠
- p.Val60Met Single submitter ⚠