CLEC1B — 52 ClinVar variants
All ClinVar germline CLEC1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
5 Likely benign · 47 Uncertain significance
Full CLEC1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC1B p.Ala34Ser Uncertain significance Single submitter
- CLEC1B p.Arg107Lys Uncertain significance Single submitter
- CLEC1B p.Arg118Thr Uncertain significance Single submitter
- CLEC1B p.Arg143Trp Uncertain significance Single submitter
- CLEC1B p.Arg59Leu Uncertain significance Single submitter
- CLEC1B p.Arg79His Uncertain significance Single submitter
- CLEC1B p.Arg79Leu Uncertain significance Single submitter
- CLEC1B p.Asn120Ser Uncertain significance Single submitter
- CLEC1B p.Asn167Ser Uncertain significance Single submitter
- CLEC1B p.Gln63Lys Uncertain significance Single submitter
- CLEC1B p.Gln74Lys Uncertain significance Single submitter
- CLEC1B p.Gln75Glu Uncertain significance Single submitter
- CLEC1B p.Glu187Lys Uncertain significance Single submitter
- CLEC1B p.Gly189Ala Uncertain significance Single submitter
- CLEC1B p.Gly189Arg Uncertain significance Single submitter
- CLEC1B p.Gly43Val Uncertain significance Single submitter
- CLEC1B p.Gly96Cys Uncertain significance Single submitter
- CLEC1B p.His97Gln Uncertain significance Single submitter
- CLEC1B p.Leu76Val Uncertain significance Single submitter
- CLEC1B p.Lys13Arg Uncertain significance Single submitter
- CLEC1B p.Lys13Glu Uncertain significance Single submitter
- CLEC1B p.Met133Ile Uncertain significance Single submitter
- CLEC1B p.Met222Lys Uncertain significance Single submitter
- CLEC1B p.Met222Val Uncertain significance Single submitter
- CLEC1B p.Phe80Ser Uncertain significance Single submitter
- CLEC1B p.Pro229Ser Uncertain significance Single submitter
- CLEC1B p.Ser126Gly Uncertain significance Single submitter
- CLEC1B p.Trp170Ser Uncertain significance Single submitter
- CLEC1B p.Trp29Ser Uncertain significance Single submitter
- CLEC1B p.Tyr61His Uncertain significance Single submitter
- CLEC1B p.Val46Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CLEC1B p.Ala34Pro Uncertain significance Single submitter
- CLEC1B p.Arg31Cys Uncertain significance Single submitter
- CLEC1B p.Arg69Gly Uncertain significance Single submitter
- CLEC1B p.Asn134Lys Uncertain significance Single submitter
- CLEC1B p.Asn192Ile Uncertain significance Single submitter
- CLEC1B p.Cys81Ser Uncertain significance Single submitter
- CLEC1B p.Glu65Gly Uncertain significance Single submitter
- CLEC1B p.Ile140Thr Uncertain significance Single submitter
- CLEC1B p.Leu62Val Uncertain significance Single submitter
- CLEC1B p.Leu76Phe Uncertain significance Single submitter
- CLEC1B p.Lys127Glu Uncertain significance Single submitter
- CLEC1B p.Lys171Gln Uncertain significance Single submitter
- CLEC1B p.Ser26Phe Uncertain significance Single submitter
- CLEC1B p.Thr70Ala Uncertain significance Single submitter
- CLEC1B p.Tyr114Phe Uncertain significance Single submitter
- CLEC1B p.Val46Phe Uncertain significance Single submitter
All CLEC1B variants
Likely benign 5
- p.Arg15Gln Single submitter
- p.Arg69Leu Single submitter
- p.Asn142Ser Single submitter
- p.Val84Leu Single submitter
- p.Val85Ile Single submitter
Uncertain significance 47
- p.Ala34Pro Single submitter ⚠
- p.Ala34Ser Single submitter ⚠
- p.Arg107Lys Single submitter ⚠
- p.Arg118Thr Single submitter ⚠
- p.Arg143Trp Single submitter ⚠
- p.Arg31Cys Single submitter ⚠
- p.Arg59Leu Single submitter ⚠
- p.Arg69Gly Single submitter ⚠
- p.Arg79His Single submitter ⚠
- p.Arg79Leu Single submitter ⚠
- p.Asn120Ser Single submitter ⚠
- p.Asn134Lys Single submitter ⚠
- p.Asn167Ser Single submitter ⚠
- p.Asn192Ile Single submitter ⚠
- p.Cys81Ser Single submitter ⚠
- p.Gln63Lys Single submitter ⚠
- p.Gln74Lys Single submitter ⚠
- p.Gln75Glu Single submitter ⚠
- p.Glu187Lys Single submitter ⚠
- p.Glu65Gly Single submitter ⚠
- p.Gly189Ala Single submitter ⚠
- p.Gly189Arg Single submitter ⚠
- p.Gly43Val Single submitter ⚠
- p.Gly96Cys Single submitter ⚠
- p.His97Gln Single submitter ⚠
- p.Ile140Thr Single submitter ⚠
- p.Leu62Val Single submitter ⚠
- p.Leu76Phe Single submitter ⚠
- p.Leu76Val Single submitter ⚠
- p.Lys127Glu Single submitter ⚠
- p.Lys13Arg Single submitter ⚠
- p.Lys13Glu Single submitter ⚠
- p.Lys171Gln Single submitter ⚠
- p.Met133Ile Single submitter ⚠
- p.Met222Lys Single submitter ⚠
- p.Met222Val Single submitter ⚠
- p.Phe80Ser Single submitter ⚠
- p.Pro229Ser Single submitter ⚠
- p.Ser126Gly Single submitter ⚠
- p.Ser26Phe Single submitter ⚠
- p.Thr70Ala Single submitter ⚠
- p.Trp170Ser Single submitter ⚠
- p.Trp29Ser Single submitter ⚠
- p.Tyr114Phe Single submitter ⚠
- p.Tyr61His Single submitter ⚠
- p.Val46Ile Single submitter ⚠
- p.Val46Phe Single submitter ⚠