CLEC2B — 22 ClinVar variants
All ClinVar germline CLEC2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
3 Likely benign · 19 Uncertain significance
Full CLEC2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 15
The independent predictors disagree with each other — read with care.
- CLEC2B p.Arg147Gly Uncertain significance Single submitter
- CLEC2B p.Arg84Trp Uncertain significance Single submitter
- CLEC2B p.Asn100Lys Uncertain significance Single submitter
- CLEC2B p.Glu53Gly Uncertain significance Single submitter
- CLEC2B p.Glu53Val Uncertain significance Single submitter
- CLEC2B p.Glu77Asp Uncertain significance Single submitter
- CLEC2B p.Gly119Arg Uncertain significance Single submitter
- CLEC2B p.Gly130Asp Uncertain significance Single submitter
- CLEC2B p.His91Arg Uncertain significance Single submitter
- CLEC2B p.Ile73Thr Uncertain significance Single submitter
- CLEC2B p.Leu34Phe Likely benign Single submitter
- CLEC2B p.Lys86Gln Uncertain significance Single submitter
- CLEC2B p.Met97Thr Uncertain significance Single submitter
- CLEC2B p.Phe115Ile Uncertain significance Single submitter
- CLEC2B p.Tyr125Ser Uncertain significance Single submitter
All CLEC2B variants
Likely benign 3
- p.Ala68= Single submitter
- p.Leu34Phe Single submitter ⚠
- p.Ser120Asn Single submitter
Uncertain significance 19
- p.Arg145Lys Single submitter ⚠
- p.Arg147Gly Single submitter ⚠
- p.Arg84Trp Single submitter ⚠
- p.Asn100Lys Single submitter ⚠
- p.Asn44Lys Single submitter ⚠
- p.Cys123Tyr Single submitter ⚠
- p.Glu53Gly Single submitter ⚠
- p.Glu53Val Single submitter ⚠
- p.Glu77Asp Single submitter ⚠
- p.Gly119Arg Single submitter ⚠
- p.Gly130Asp Single submitter ⚠
- p.His91Arg Single submitter ⚠
- p.Ile73Thr Single submitter ⚠
- p.Lys86Gln Single submitter ⚠
- p.Met97Thr Single submitter ⚠
- p.Met97Val Single submitter ⚠
- p.Phe115Ile Single submitter ⚠
- p.Tyr125Ser Single submitter ⚠
- p.Tyr37His Single submitter ⚠