CLEC2D — 12 ClinVar variants
All ClinVar germline CLEC2D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
12 Uncertain significance
Full CLEC2D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 6
The independent predictors disagree with each other — read with care.
- CLEC2D p.Gln117Leu Uncertain significance Single submitter
- CLEC2D p.Gly161Arg Uncertain significance Single submitter
- CLEC2D p.Phe102Leu Uncertain significance Single submitter
- CLEC2D p.Ser14Phe Uncertain significance Single submitter
- CLEC2D p.Tyr125Phe Uncertain significance Single submitter
- CLEC2D p.Tyr88Cys Uncertain significance Single submitter
All CLEC2D variants
Uncertain significance 12
- c.461+162G>A Single submitter
- c.461+183T>C Single submitter
- p.Asp109Asn Single submitter ⚠
- p.Gln117Leu Single submitter ⚠
- p.Gln154His Single submitter ⚠
- p.Gly161Arg Single submitter ⚠
- p.Ile47Val Single submitter ⚠
- p.Phe102Leu Single submitter ⚠
- p.Ser14Phe Single submitter ⚠
- p.Thr93Asn Single submitter ⚠
- p.Tyr125Phe Single submitter ⚠
- p.Tyr88Cys Single submitter ⚠