CLEC2L — 42 ClinVar variants
All ClinVar germline CLEC2L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
42 Uncertain significance
Full CLEC2L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC2L p.Ala182Thr Uncertain significance Single submitter
- CLEC2L p.Ala26Gly Uncertain significance Single submitter
- CLEC2L p.Ala27Thr Uncertain significance Single submitter
- CLEC2L p.Ala34Ser Uncertain significance Single submitter
- CLEC2L p.Ala34Thr Uncertain significance Single submitter
- CLEC2L p.Arg160His Uncertain significance Single submitter
- CLEC2L p.Arg46Leu Uncertain significance Single submitter
- CLEC2L p.Asp177Gly Uncertain significance Single submitter
- CLEC2L p.Gln126Glu Uncertain significance Single submitter
- CLEC2L p.His131Gln Uncertain significance Single submitter
- CLEC2L p.Ile94Met Uncertain significance Single submitter
- CLEC2L p.Leu45Pro Uncertain significance Single submitter
- CLEC2L p.Pro25Ala Uncertain significance Single submitter
- CLEC2L p.Ser48Pro Uncertain significance Single submitter
- CLEC2L p.Thr214Ser Uncertain significance Single submitter
- CLEC2L p.Trp156Arg Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- CLEC2L p.Ala24Val Uncertain significance Single submitter
- CLEC2L p.Ala80Thr Uncertain significance Single submitter
- CLEC2L p.Arg152Trp Uncertain significance Single submitter
- CLEC2L p.Arg29Lys Uncertain significance Single submitter
- CLEC2L p.Asp172Asn Uncertain significance Single submitter
- CLEC2L p.Cys93Tyr Uncertain significance Single submitter
- CLEC2L p.Glu116Lys Uncertain significance Single submitter
- CLEC2L p.Glu132Lys Uncertain significance Single submitter
- CLEC2L p.Gly51Asp Uncertain significance Single submitter
- CLEC2L p.His131Asp Uncertain significance Single submitter
- CLEC2L p.Leu82Phe Uncertain significance Single submitter
- CLEC2L p.Lys91Asn Uncertain significance Single submitter
- CLEC2L p.Phe113Leu Uncertain significance Single submitter
- CLEC2L p.Phe79Ile Uncertain significance Single submitter
- CLEC2L p.Pro101Leu Uncertain significance Single submitter
- CLEC2L p.Pro14Ser Uncertain significance Single submitter
- CLEC2L p.Pro15Gln Uncertain significance Single submitter
- CLEC2L p.Pro23His Uncertain significance Single submitter
- CLEC2L p.Pro25Ser Uncertain significance Single submitter
- CLEC2L p.Pro7Ala Uncertain significance Single submitter
- CLEC2L p.Ser209Arg Uncertain significance Single submitter
- CLEC2L p.Ser209Ile Uncertain significance Single submitter
- CLEC2L p.Thr151Met Uncertain significance Single submitter
- CLEC2L p.Thr198Met Uncertain significance Single submitter
- CLEC2L p.Val137Leu Uncertain significance Single submitter
- CLEC2L p.Val162Ala Uncertain significance Single submitter
All CLEC2L variants
Uncertain significance 42
- p.Ala182Thr Single submitter ⚠
- p.Ala24Val Single submitter ⚠
- p.Ala26Gly Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala34Ser Single submitter ⚠
- p.Ala34Thr Single submitter ⚠
- p.Ala80Thr Single submitter ⚠
- p.Arg152Trp Single submitter ⚠
- p.Arg160His Single submitter ⚠
- p.Arg29Lys Single submitter ⚠
- p.Arg46Leu Single submitter ⚠
- p.Asp172Asn Single submitter ⚠
- p.Asp177Gly Single submitter ⚠
- p.Cys93Tyr Single submitter ⚠
- p.Gln126Glu Single submitter ⚠
- p.Glu116Lys Single submitter ⚠
- p.Glu132Lys Single submitter ⚠
- p.Gly51Asp Single submitter ⚠
- p.His131Asp Single submitter ⚠
- p.His131Gln Single submitter ⚠
- p.Ile94Met Single submitter ⚠
- p.Leu45Pro Single submitter ⚠
- p.Leu82Phe Single submitter ⚠
- p.Lys91Asn Single submitter ⚠
- p.Phe113Leu Single submitter ⚠
- p.Phe79Ile Single submitter ⚠
- p.Pro101Leu Single submitter ⚠
- p.Pro14Ser Single submitter ⚠
- p.Pro15Gln Single submitter ⚠
- p.Pro23His Single submitter ⚠
- p.Pro25Ala Single submitter ⚠
- p.Pro25Ser Single submitter ⚠
- p.Pro7Ala Single submitter ⚠
- p.Ser209Arg Single submitter ⚠
- p.Ser209Ile Single submitter ⚠
- p.Ser48Pro Single submitter ⚠
- p.Thr151Met Single submitter ⚠
- p.Thr198Met Single submitter ⚠
- p.Thr214Ser Single submitter ⚠
- p.Trp156Arg Single submitter ⚠
- p.Val137Leu Single submitter ⚠
- p.Val162Ala Single submitter ⚠