CLEC3A — 8 ClinVar variants
All ClinVar germline CLEC3A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
8 Uncertain significance
Full CLEC3A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC3A p.Asp116Asn Uncertain significance Single submitter
- CLEC3A p.Gln47Arg Uncertain significance Single submitter
- CLEC3A p.Lys140Glu Uncertain significance Single submitter
- CLEC3A p.Lys76Asn Uncertain significance Single submitter
- CLEC3A p.Ser186Gly Uncertain significance Single submitter
- CLEC3A p.Ser22Cys Uncertain significance Single submitter
All CLEC3A variants
Uncertain significance 8
- p.Asp116Asn Single submitter ⚠
- p.Asp180Val Single submitter
- p.Gln47Arg Single submitter ⚠
- p.Lys140Glu Single submitter ⚠
- p.Lys76Asn Single submitter ⚠
- p.Met1Val Single submitter
- p.Ser186Gly Single submitter ⚠
- p.Ser22Cys Single submitter ⚠