CLEC4C — 25 ClinVar variants
All ClinVar germline CLEC4C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
2 Benign · 1 Likely benign · 22 Uncertain significance
Full CLEC4C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC4C p.Ala116Ser Uncertain significance Single submitter
- CLEC4C p.Ala181Thr Uncertain significance Single submitter
- CLEC4C p.Arg150Gln Uncertain significance Single submitter
- CLEC4C p.Arg186His Uncertain significance Single submitter
- CLEC4C p.Asn162Asp Uncertain significance Single submitter
- CLEC4C p.Gln202Arg Uncertain significance Single submitter
- CLEC4C p.Glu6Gln Uncertain significance Single submitter
- CLEC4C p.His44Gln Uncertain significance Single submitter
- CLEC4C p.Ile77Val Uncertain significance Single submitter
- CLEC4C p.Leu144Pro Uncertain significance Single submitter
- CLEC4C p.Leu14Phe Uncertain significance Single submitter
- CLEC4C p.Leu31Ile Uncertain significance Single submitter
- CLEC4C p.Lys12Arg Uncertain significance Single submitter
- CLEC4C p.Lys57Gln Uncertain significance Single submitter
- CLEC4C p.Met47Ile Uncertain significance Single submitter
- CLEC4C p.Val120Ala Uncertain significance Single submitter
- CLEC4C p.Val27Ile Uncertain significance Single submitter
- CLEC4C p.Val2Met Uncertain significance Single submitter
- CLEC4C p.Val71Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CLEC4C variants
Benign 2
- p.Asn122Lys Multiple submitters
- p.Leu58Val Multiple submitters
Likely benign 1
- p.His65Tyr Single submitter
Uncertain significance 22
- p.Ala116Ser Single submitter ⚠
- p.Ala181Thr Single submitter ⚠
- p.Arg150Gln Single submitter ⚠
- p.Arg186Cys Single submitter ⚠
- p.Arg186His Single submitter ⚠
- p.Asn162Asp Single submitter ⚠
- p.Gln202Arg Single submitter ⚠
- p.Glu6Gln Single submitter ⚠
- p.His44Gln Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Leu144Pro Single submitter ⚠
- p.Leu14Phe Single submitter ⚠
- p.Leu31Ile Single submitter ⚠
- p.Leu55Pro Single submitter ⚠
- p.Lys12Arg Single submitter ⚠
- p.Lys57Gln Single submitter ⚠
- p.Met47Ile Single submitter ⚠
- p.Val120Ala Single submitter ⚠
- p.Val27Ile Single submitter ⚠
- p.Val2Met Single submitter ⚠
- p.Val34Asp Single submitter ⚠
- p.Val71Ile Single submitter ⚠