CLEC4E — 27 ClinVar variants
All ClinVar germline CLEC4E variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
4 Likely benign · 23 Uncertain significance
Full CLEC4E gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC4E p.Ala102Glu Uncertain significance Single submitter
- CLEC4E p.Ala102Val Uncertain significance Single submitter
- CLEC4E p.Arg14Thr Uncertain significance Single submitter
- CLEC4E p.Arg189Lys Uncertain significance Single submitter
- CLEC4E p.Asn214Lys Uncertain significance Single submitter
- CLEC4E p.Asn2His Uncertain significance Single submitter
- CLEC4E p.Asn70Ser Uncertain significance Single submitter
- CLEC4E p.Cys52Tyr Uncertain significance Single submitter
- CLEC4E p.Gln121Arg Uncertain significance Single submitter
- CLEC4E p.Gln58Arg Uncertain significance Single submitter
- CLEC4E p.Gly155Ser Uncertain significance Single submitter
- CLEC4E p.Ile39Thr Uncertain significance Single submitter
- CLEC4E p.Ile48Val Uncertain significance Single submitter
- CLEC4E p.Leu213Phe Uncertain significance Single submitter
- CLEC4E p.Lys215Glu Uncertain significance Single submitter
- CLEC4E p.Lys55Glu Uncertain significance Single submitter
- CLEC4E p.Thr51Asn Uncertain significance Single submitter
- CLEC4E p.Thr96Ala Uncertain significance Single submitter
- CLEC4E p.Val167Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CLEC4E variants
Likely benign 4
- p.Asn200Ser Single submitter
- p.Leu82Ser Single submitter
- p.Thr51Ile Single submitter
- p.Val117Ile Single submitter
Uncertain significance 23
- p.Ala102Glu Single submitter ⚠
- p.Ala102Val Single submitter ⚠
- p.Arg14Thr Single submitter ⚠
- p.Arg189Lys Single submitter ⚠
- p.Asn214Lys Single submitter ⚠
- p.Asn2His Single submitter ⚠
- p.Asn70Ser Single submitter ⚠
- p.Cys52Tyr Single submitter ⚠
- p.Gln121Arg Single submitter ⚠
- p.Gln58Arg Single submitter ⚠
- p.Gly148Val Single submitter ⚠
- p.Gly155Ser Single submitter ⚠
- p.Ile139Thr Single submitter ⚠
- p.Ile39Thr Single submitter ⚠
- p.Ile48Val Single submitter ⚠
- p.Leu213Phe Single submitter ⚠
- p.Lys131Glu Single submitter ⚠
- p.Lys215Glu Single submitter ⚠
- p.Lys55Glu Single submitter ⚠
- p.Ser90Asn Single submitter ⚠
- p.Thr51Asn Single submitter ⚠
- p.Thr96Ala Single submitter ⚠
- p.Val167Ile Single submitter ⚠