CLEC4F — 92 ClinVar variants

All ClinVar germline CLEC4F variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →

1 Conflicting · 2 Benign · 1 Benign/Likely benign · 12 Likely benign · 76 Uncertain significance

Full CLEC4F gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 80

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

CLEC4F p.Gly533Asp Conflicting Single submitter

Predictors lean, ClinVar uncertain 52

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 27

The independent predictors disagree with each other — read with care.

All CLEC4F variants

Conflicting classifications of pathogenicity 1

p.Gly533Asp Single submitter ⚠

Benign 2

p.Asn146Ser Multiple submitters
p.Val369Ala Multiple submitters

Benign/Likely benign 1

p.Thr235Met Multiple submitters ⚠

Likely benign 12

p.Ala304Thr Single submitter
p.Ala98Thr Single submitter
p.Asn551Ser Single submitter
p.Glu185Gly Single submitter
p.Gly396Glu Single submitter
p.Ile390Met Single submitter ⚠
p.Ser263Arg Single submitter ⚠
p.Ser521Gly Single submitter
p.Val119Ala Single submitter
p.Val214Met Single submitter
p.Val333Met Single submitter
p.Val38Ile Single submitter

Uncertain significance 76

p.Ala192Thr Single submitter ⚠
p.Ala222Thr Single submitter ⚠
p.Ala26Thr Single submitter ⚠
p.Ala28Gly Single submitter ⚠
p.Ala386Gly Single submitter ⚠
p.Ala402Gly Single submitter ⚠
p.Ala40Thr Single submitter ⚠
p.Ala5Val Single submitter ⚠
p.Arg444Leu Single submitter ⚠
p.Arg532Ser Single submitter ⚠
p.Arg563Thr Single submitter ⚠
p.Arg7Gly Single submitter ⚠
p.Asn113His Single submitter ⚠
p.Asn132Asp Single submitter ⚠
p.Asn276Thr Single submitter ⚠
p.Asn476Ser Single submitter ⚠
p.Asp262Gly Single submitter ⚠
p.Cys560Tyr Single submitter ⚠
p.Gln13Glu Single submitter ⚠
p.Gln196His Single submitter ⚠
p.Gln391Arg Single submitter ⚠
p.Gln39Arg Single submitter ⚠
p.Gln408Arg Single submitter ⚠
p.Gln495Pro Single submitter ⚠
p.Gln62Pro Single submitter ⚠
p.Glu174Gln Single submitter ⚠
p.Glu179Asp Single submitter ⚠
p.Glu185Lys Single submitter ⚠
p.Glu188Gly Single submitter ⚠
p.Glu206Gly Single submitter ⚠
p.Glu365Gln Single submitter ⚠
p.Glu420Lys Single submitter ⚠
p.Glu441Lys Single submitter ⚠
p.Gly322Ser Single submitter ⚠
p.Gly472Asp Single submitter ⚠
p.Gly555Asp Single submitter ⚠
p.Gly558Arg Single submitter ⚠
p.His110Tyr Single submitter ⚠
p.His18Gln Single submitter ⚠
p.His18Tyr Single submitter ⚠
p.His91Arg Single submitter ⚠
p.Ile567Thr Single submitter ⚠
p.Leu103His Single submitter ⚠
p.Leu414Pro Single submitter ⚠
p.Leu504Met Single submitter ⚠
p.Lys335Gln Single submitter ⚠
p.Lys488Arg Single submitter ⚠
p.Lys564Asn Single submitter ⚠
p.Lys564Glu Single submitter ⚠
p.Met151Thr Single submitter ⚠
p.Met168Ile Single submitter ⚠
p.Met366Val Single submitter ⚠
p.Met383Thr Single submitter ⚠
p.Phe200Ile Single submitter ⚠
p.Phe515Leu Single submitter ⚠
p.Pro545Ala Single submitter ⚠
p.Pro561Thr Single submitter ⚠
p.Ser232Asn Single submitter ⚠
p.Ser246Gly Single submitter ⚠
p.Ser277Gly Single submitter ⚠
p.Ser570Phe Single submitter ⚠
p.Thr10Ala Single submitter ⚠
p.Thr160Ile Single submitter ⚠
p.Thr208Ala Single submitter ⚠
p.Thr520Ala Single submitter ⚠
p.Thr530Ile Single submitter ⚠
p.Thr580Asn Single submitter ⚠
p.Trp117Arg Single submitter ⚠
p.Trp526Arg Single submitter ⚠
p.Val128Leu Single submitter ⚠
p.Val155Ala Single submitter ⚠
p.Val361Ile Single submitter ⚠
p.Val450Leu Single submitter ⚠
p.Val498Gly Single submitter ⚠
p.Val58Leu Single submitter ⚠
p.Val59Met Single submitter ⚠