CLEC4G — 24 ClinVar variants
All ClinVar germline CLEC4G variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 23 Uncertain significance
Full CLEC4G gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC4G p.Ala196Ser Uncertain significance Single submitter
- CLEC4G p.Ala258Val Uncertain significance Single submitter
- CLEC4G p.Gly66Ser Uncertain significance Single submitter
- CLEC4G p.Gly82Asp Uncertain significance Single submitter
- CLEC4G p.Gly97Arg Uncertain significance Single submitter
- CLEC4G p.Pro17Arg Uncertain significance Single submitter
- CLEC4G p.Ser121Arg Uncertain significance Single submitter
- CLEC4G p.Ser175Pro Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CLEC4G p.Ala276Thr Uncertain significance Single submitter
- CLEC4G p.Arg106His Uncertain significance Single submitter
- CLEC4G p.Arg127His Uncertain significance Single submitter
- CLEC4G p.Arg226Lys Uncertain significance Single submitter
- CLEC4G p.Arg23Cys Uncertain significance Single submitter
- CLEC4G p.Asn274Ser Uncertain significance Single submitter
- CLEC4G p.Asn73Lys Uncertain significance Single submitter
- CLEC4G p.Asp2Asn Uncertain significance Single submitter
- CLEC4G p.Glu118Lys Uncertain significance Single submitter
- CLEC4G p.Glu14Lys Uncertain significance Single submitter
- CLEC4G p.Leu109Pro Uncertain significance Single submitter
- CLEC4G p.Leu49Pro Uncertain significance Single submitter
- CLEC4G p.Ser168Leu Uncertain significance Single submitter
- CLEC4G p.Tyr6Cys Uncertain significance Single submitter
- CLEC4G p.Val40Ile Uncertain significance Single submitter
All CLEC4G variants
Likely benign 1
- p.Asp90Ala Single submitter
Uncertain significance 23
- p.Ala196Ser Single submitter ⚠
- p.Ala258Val Single submitter ⚠
- p.Ala276Thr Single submitter ⚠
- p.Arg106His Single submitter ⚠
- p.Arg127His Single submitter ⚠
- p.Arg226Lys Single submitter ⚠
- p.Arg23Cys Single submitter ⚠
- p.Asn274Ser Single submitter ⚠
- p.Asn73Lys Single submitter ⚠
- p.Asp2Asn Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu14Lys Single submitter ⚠
- p.Gly66Ser Single submitter ⚠
- p.Gly82Asp Single submitter ⚠
- p.Gly97Arg Single submitter ⚠
- p.Leu109Pro Single submitter ⚠
- p.Leu49Pro Single submitter ⚠
- p.Pro17Arg Single submitter ⚠
- p.Ser121Arg Single submitter ⚠
- p.Ser168Leu Single submitter ⚠
- p.Ser175Pro Single submitter ⚠
- p.Tyr6Cys Single submitter ⚠
- p.Val40Ile Single submitter ⚠