CLEC4M — 36 ClinVar variants
All ClinVar germline CLEC4M variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
7 Likely benign · 29 Uncertain significance
Full CLEC4M gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC4M p.Ala394Gly Uncertain significance Single submitter
- CLEC4M p.Ala62Gly Uncertain significance Single submitter
- CLEC4M p.Gln11Lys Uncertain significance Single submitter
- CLEC4M p.Glu17Lys Uncertain significance Single submitter
- CLEC4M p.His39Tyr Uncertain significance Single submitter
- CLEC4M p.Ile24Leu Uncertain significance Single submitter
- CLEC4M p.Leu79Ile Uncertain significance Single submitter
- CLEC4M p.Lys270Arg Uncertain significance Single submitter
- CLEC4M p.Met59Ile Uncertain significance Single submitter
- CLEC4M p.Val304Ala Uncertain significance Single submitter
- CLEC4M p.Val9Gly Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CLEC4M p.Ala145Val Uncertain significance Single submitter
- CLEC4M p.Ala237Thr Uncertain significance Single submitter
- CLEC4M p.Ala295Val Uncertain significance Single submitter
- CLEC4M p.Ala393Val Uncertain significance Single submitter
- CLEC4M p.Arg141Trp Uncertain significance Single submitter
- CLEC4M p.Arg353Trp Uncertain significance Single submitter
- CLEC4M p.Asp271Glu Likely benign Single submitter
- CLEC4M p.Asp271Val Uncertain significance Single submitter
- CLEC4M p.Gln114Lys Uncertain significance Single submitter
- CLEC4M p.Glu157Ala Uncertain significance Single submitter
- CLEC4M p.Ile135Val Uncertain significance Single submitter
- CLEC4M p.Ile306Val Uncertain significance Single submitter
- CLEC4M p.Lys177Glu Uncertain significance Single submitter
- CLEC4M p.Phe351Ser Uncertain significance Single submitter
- CLEC4M p.Pro150Thr Uncertain significance Single submitter
- CLEC4M p.Ser245Phe Uncertain significance Single submitter
- CLEC4M p.Trp339Arg Uncertain significance Single submitter
- CLEC4M p.Val123Ala Uncertain significance Single submitter
- CLEC4M p.Val123Leu Uncertain significance Single submitter
All CLEC4M variants
Likely benign 7
- p.Ala122= Single submitter
- p.Arg141Gln Single submitter
- p.Arg353= Single submitter
- p.Asp271Glu Single submitter ⚠
- p.Gln233Arg Single submitter
- p.Gly49= Single submitter
- p.Thr209= Single submitter
Uncertain significance 29
- p.Ala145Val Single submitter ⚠
- p.Ala237Thr Single submitter ⚠
- p.Ala295Val Single submitter ⚠
- p.Ala393Val Single submitter ⚠
- p.Ala394Gly Single submitter ⚠
- p.Ala62Gly Single submitter ⚠
- p.Arg141Trp Single submitter ⚠
- p.Arg353Trp Single submitter ⚠
- p.Asp271Val Single submitter ⚠
- p.Gln114Lys Single submitter ⚠
- p.Gln11Lys Single submitter ⚠
- p.Glu157Ala Single submitter ⚠
- p.Glu17Lys Single submitter ⚠
- p.His39Tyr Single submitter ⚠
- p.Ile135Val Single submitter ⚠
- p.Ile24Leu Single submitter ⚠
- p.Ile306Val Single submitter ⚠
- p.Leu79Ile Single submitter ⚠
- p.Lys177Glu Single submitter ⚠
- p.Lys270Arg Single submitter ⚠
- p.Met59Ile Single submitter ⚠
- p.Phe351Ser Single submitter ⚠
- p.Pro150Thr Single submitter ⚠
- p.Ser245Phe Single submitter ⚠
- p.Trp339Arg Single submitter ⚠
- p.Val123Ala Single submitter ⚠
- p.Val123Leu Single submitter ⚠
- p.Val304Ala Single submitter ⚠
- p.Val9Gly Single submitter ⚠