CLEC5A — 25 ClinVar variants
All ClinVar germline CLEC5A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
25 Uncertain significance
Full CLEC5A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC5A p.Ala162Gly Uncertain significance Single submitter
- CLEC5A p.Arg135His Uncertain significance Single submitter
- CLEC5A p.Arg141Cys Uncertain significance Single submitter
- CLEC5A p.Arg180His Uncertain significance Single submitter
- CLEC5A p.Asn32Ser Uncertain significance Single submitter
- CLEC5A p.Asn35Asp Uncertain significance Single submitter
- CLEC5A p.Asp97Glu Uncertain significance Single submitter
- CLEC5A p.Gln155Glu Uncertain significance Single submitter
- CLEC5A p.Gln157His Uncertain significance Single submitter
- CLEC5A p.Gly103Ala Uncertain significance Single submitter
- CLEC5A p.Gly68Arg Uncertain significance Single submitter
- CLEC5A p.Ile108Val Uncertain significance Single submitter
- CLEC5A p.Ile62Thr Uncertain significance Single submitter
- CLEC5A p.Lys116Glu Uncertain significance Single submitter
- CLEC5A p.Ser53Arg Uncertain significance Single submitter
- CLEC5A p.Ser55Phe Uncertain significance Single submitter
- CLEC5A p.Ser88Thr Uncertain significance Single submitter
- CLEC5A p.Ser91Thr Uncertain significance Single submitter
- CLEC5A p.Thr41Asn Uncertain significance Single submitter
- CLEC5A p.Thr69Lys Uncertain significance Single submitter
- CLEC5A p.Val109Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CLEC5A variants
Uncertain significance 25
- p.Ala162Gly Single submitter ⚠
- p.Arg135Cys Single submitter ⚠
- p.Arg135His Single submitter ⚠
- p.Arg141Cys Single submitter ⚠
- p.Arg180Cys Single submitter ⚠
- p.Arg180His Single submitter ⚠
- p.Arg180Leu Single submitter ⚠
- p.Asn32Ser Single submitter ⚠
- p.Asn35Asp Single submitter ⚠
- p.Asp97Glu Single submitter ⚠
- p.Gln155Glu Single submitter ⚠
- p.Gln157His Single submitter ⚠
- p.Gly103Ala Single submitter ⚠
- p.Gly68Arg Single submitter ⚠
- p.Ile108Val Single submitter ⚠
- p.Ile62Thr Single submitter ⚠
- p.Lys116Glu Single submitter ⚠
- p.Ser53Arg Single submitter ⚠
- p.Ser55Phe Single submitter ⚠
- p.Ser88Thr Single submitter ⚠
- p.Ser91Thr Single submitter ⚠
- p.Thr41Asn Single submitter ⚠
- p.Thr69Lys Single submitter ⚠
- p.Tyr67Cys Single submitter ⚠
- p.Val109Ala Single submitter ⚠