CLEC6A — 26 ClinVar variants
All ClinVar germline CLEC6A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
4 Likely benign · 22 Uncertain significance
Full CLEC6A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC6A p.Ala81Pro Uncertain significance Single submitter
- CLEC6A p.Asn146Asp Uncertain significance Single submitter
- CLEC6A p.Asn160Ser Uncertain significance Single submitter
- CLEC6A p.Asn170Ser Uncertain significance Single submitter
- CLEC6A p.Glu132Lys Uncertain significance Single submitter
- CLEC6A p.His61Gln Uncertain significance Single submitter
- CLEC6A p.Ile179Val Uncertain significance Single submitter
- CLEC6A p.Ile36Thr Uncertain significance Single submitter
- CLEC6A p.Pro156Leu Uncertain significance Single submitter
- CLEC6A p.Pro7Leu Uncertain significance Single submitter
- CLEC6A p.Ser9Thr Uncertain significance Single submitter
- CLEC6A p.Thr50Ile Uncertain significance Single submitter
- CLEC6A p.Tyr43Ser Uncertain significance Single submitter
- CLEC6A p.Val192Phe Uncertain significance Single submitter
- CLEC6A p.Val73Met Uncertain significance Single submitter
- CLEC6A p.Val99Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CLEC6A p.Asn190Ser Uncertain significance Single submitter
- CLEC6A p.Glu168Lys Uncertain significance Single submitter
- CLEC6A p.Met110Ile Uncertain significance Single submitter
- CLEC6A p.Pro143Thr Uncertain significance Single submitter
- CLEC6A p.Ser89Gly Uncertain significance Single submitter
- CLEC6A p.Ser94Phe Uncertain significance Single submitter
All CLEC6A variants
Likely benign 4
- p.Gln175Lys Single submitter
- p.Phe134Leu Single submitter
- p.Ser95Gly Single submitter
- p.Val99Phe Single submitter
Uncertain significance 22
- p.Ala81Pro Single submitter ⚠
- p.Asn146Asp Single submitter ⚠
- p.Asn160Ser Single submitter ⚠
- p.Asn170Ser Single submitter ⚠
- p.Asn190Ser Single submitter ⚠
- p.Glu132Lys Single submitter ⚠
- p.Glu168Lys Single submitter ⚠
- p.His61Gln Single submitter ⚠
- p.Ile179Val Single submitter ⚠
- p.Ile36Thr Single submitter ⚠
- p.Met110Ile Single submitter ⚠
- p.Pro143Thr Single submitter ⚠
- p.Pro156Leu Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Ser89Gly Single submitter ⚠
- p.Ser94Phe Single submitter ⚠
- p.Ser9Thr Single submitter ⚠
- p.Thr50Ile Single submitter ⚠
- p.Tyr43Ser Single submitter ⚠
- p.Val192Phe Single submitter ⚠
- p.Val73Met Single submitter ⚠
- p.Val99Ala Single submitter ⚠