CLEC9A — 33 ClinVar variants
All ClinVar germline CLEC9A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Benign · 6 Likely benign · 26 Uncertain significance
Full CLEC9A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC9A p.Ala65Val Uncertain significance Single submitter
- CLEC9A p.Asp13Gly Uncertain significance Single submitter
- CLEC9A p.Gln21Arg Uncertain significance Single submitter
- CLEC9A p.Gln97Leu Uncertain significance Single submitter
- CLEC9A p.Glu122Gly Uncertain significance Single submitter
- CLEC9A p.Glu3Lys Uncertain significance Single submitter
- CLEC9A p.Gly184Arg Uncertain significance Single submitter
- CLEC9A p.Gly31Glu Uncertain significance Single submitter
- CLEC9A p.His2Tyr Uncertain significance Single submitter
- CLEC9A p.Ile39Val Uncertain significance Single submitter
- CLEC9A p.Ile64Thr Uncertain significance Single submitter
- CLEC9A p.Ile73Val Uncertain significance Single submitter
- CLEC9A p.Met93Lys Uncertain significance Single submitter
- CLEC9A p.Met93Thr Uncertain significance Single submitter
- CLEC9A p.Ser163Asn Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CLEC9A p.Arg185Cys Uncertain significance Single submitter
- CLEC9A p.Arg185His Uncertain significance Single submitter
- CLEC9A p.Gln75His Uncertain significance Single submitter
- CLEC9A p.Glu233Lys Uncertain significance Single submitter
- CLEC9A p.Glu70Ala Uncertain significance Single submitter
- CLEC9A p.Ile231Leu Uncertain significance Single submitter
- CLEC9A p.Ile39Met Uncertain significance Single submitter
- CLEC9A p.Pro112Arg Uncertain significance Single submitter
- CLEC9A p.Ser88Arg Uncertain significance Single submitter
- CLEC9A p.Thr147Met Uncertain significance Single submitter
- CLEC9A p.Val241Asp Uncertain significance Single submitter
All CLEC9A variants
Benign 1
- p.Ala16Thr Multiple submitters
Likely benign 6
- p.Asn102Ser Single submitter
- p.Glu202Gln Single submitter
- p.Gly197Asp Single submitter
- p.Met45Val Single submitter
- p.Phe99Leu Single submitter
- p.Val56Ile Single submitter
Uncertain significance 26
- p.Ala65Val Single submitter ⚠
- p.Arg185Cys Single submitter ⚠
- p.Arg185His Single submitter ⚠
- p.Asp13Gly Single submitter ⚠
- p.Gln21Arg Single submitter ⚠
- p.Gln75His Single submitter ⚠
- p.Gln97Leu Single submitter ⚠
- p.Glu122Gly Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Glu3Lys Single submitter ⚠
- p.Glu70Ala Single submitter ⚠
- p.Gly184Arg Single submitter ⚠
- p.Gly31Glu Single submitter ⚠
- p.His2Tyr Single submitter ⚠
- p.Ile231Leu Single submitter ⚠
- p.Ile39Met Single submitter ⚠
- p.Ile39Val Single submitter ⚠
- p.Ile64Thr Single submitter ⚠
- p.Ile73Val Single submitter ⚠
- p.Met93Lys Single submitter ⚠
- p.Met93Thr Single submitter ⚠
- p.Pro112Arg Single submitter ⚠
- p.Ser163Asn Single submitter ⚠
- p.Ser88Arg Single submitter ⚠
- p.Thr147Met Single submitter ⚠
- p.Val241Asp Single submitter ⚠