CLIC1 — 26 ClinVar variants
All ClinVar germline CLIC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
4 Likely benign · 22 Uncertain significance
Full CLIC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLIC1 p.Ala157Asp Uncertain significance Single submitter
- CLIC1 p.Arg204Pro Uncertain significance Single submitter
- CLIC1 p.Arg92Ser Uncertain significance Single submitter
- CLIC1 p.Gly61Val Uncertain significance Single submitter
- CLIC1 p.Ile21Thr Uncertain significance Single submitter
- CLIC1 p.Ile80Thr Uncertain significance Single submitter
- CLIC1 p.Leu137Pro Uncertain significance Single submitter
- CLIC1 p.Pro200Ser Uncertain significance Single submitter
- CLIC1 p.Ser211Asn Uncertain significance Single submitter
- CLIC1 p.Thr174Ile Uncertain significance Single submitter
- CLIC1 p.Tyr209Asp Uncertain significance Single submitter
- CLIC1 p.Val152Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CLIC1 p.Glu234Lys Uncertain significance Single submitter
- CLIC1 p.Glu4Gly Uncertain significance Single submitter
- CLIC1 p.Glu9Lys Uncertain significance Single submitter
- CLIC1 p.Gly196Arg Uncertain significance Single submitter
- CLIC1 p.Gly62Trp Uncertain significance Single submitter
- CLIC1 p.His207Arg Uncertain significance Single submitter
- CLIC1 p.Lys138Asn Uncertain significance Single submitter
- CLIC1 p.Pro6Arg Uncertain significance Single submitter
- CLIC1 p.Thr45Ile Uncertain significance Single submitter
- CLIC1 p.Val12Met Uncertain significance Single submitter
All CLIC1 variants
Likely benign 4
- p.Arg204Gln Single submitter
- p.Gly170Ser Single submitter
- p.Ser146Thr Single submitter
- p.Ser211Arg Single submitter
Uncertain significance 22
- p.Ala157Asp Single submitter ⚠
- p.Arg204Pro Single submitter ⚠
- p.Arg92Ser Single submitter ⚠
- p.Glu234Lys Single submitter ⚠
- p.Glu4Gly Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly196Arg Single submitter ⚠
- p.Gly61Val Single submitter ⚠
- p.Gly62Trp Single submitter ⚠
- p.His207Arg Single submitter ⚠
- p.Ile21Thr Single submitter ⚠
- p.Ile80Thr Single submitter ⚠
- p.Leu137Pro Single submitter ⚠
- p.Lys138Asn Single submitter ⚠
- p.Pro200Ser Single submitter ⚠
- p.Pro6Arg Single submitter ⚠
- p.Ser211Asn Single submitter ⚠
- p.Thr174Ile Single submitter ⚠
- p.Thr45Ile Single submitter ⚠
- p.Tyr209Asp Single submitter ⚠
- p.Val12Met Single submitter ⚠
- p.Val152Leu Single submitter ⚠