CLIC3 — 37 ClinVar variants
All ClinVar germline CLIC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
37 Uncertain significance
Full CLIC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLIC3 p.Ala188Thr Uncertain significance Single submitter
- CLIC3 p.Cys22Tyr Uncertain significance Single submitter
- CLIC3 p.Glu125Gly Uncertain significance Single submitter
- CLIC3 p.Gly105Ser Uncertain significance Single submitter
- CLIC3 p.Leu142Pro Uncertain significance Single submitter
- CLIC3 p.Leu176Pro Uncertain significance Single submitter
- CLIC3 p.Lys35Asn Uncertain significance Single submitter
- CLIC3 p.Lys54Arg Uncertain significance Single submitter
- CLIC3 p.Phe115Tyr Uncertain significance Single submitter
- CLIC3 p.Pro178Leu Uncertain significance Single submitter
- CLIC3 p.Pro220Thr Uncertain significance Single submitter
- CLIC3 p.Pro231Ser Uncertain significance Single submitter
- CLIC3 p.Thr85Lys Uncertain significance Single submitter
- CLIC3 p.Val19Glu Uncertain significance Single submitter
- CLIC3 p.Val19Met Uncertain significance Single submitter
- CLIC3 p.Val202Leu Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CLIC3 p.Ala151Val Uncertain significance Single submitter
- CLIC3 p.Ala209Thr Uncertain significance Single submitter
- CLIC3 p.Ala2Val Uncertain significance Single submitter
- CLIC3 p.Arg191Cys Uncertain significance Single submitter
- CLIC3 p.Arg200His Uncertain significance Single submitter
- CLIC3 p.Arg204Ser Uncertain significance Single submitter
- CLIC3 p.Arg27Gln Uncertain significance Single submitter
- CLIC3 p.Glu198Lys Uncertain significance Single submitter
- CLIC3 p.His189Gln Uncertain significance Single submitter
- CLIC3 p.Ile116Leu Uncertain significance Single submitter
- CLIC3 p.Leu180Met Uncertain significance Single submitter
- CLIC3 p.Leu62Arg Uncertain significance Single submitter
- CLIC3 p.Phe91Ile Uncertain significance Single submitter
- CLIC3 p.Pro88Leu Uncertain significance Single submitter
- CLIC3 p.Ser175Arg Uncertain significance Single submitter
- CLIC3 p.Ser18Arg Uncertain significance Single submitter
- CLIC3 p.Thr170Met Uncertain significance Single submitter
- CLIC3 p.Tyr217His Uncertain significance Single submitter
- CLIC3 p.Val186Ala Uncertain significance Single submitter
- CLIC3 p.Val233Met Uncertain significance Single submitter
- CLIC3 p.Val37Ala Uncertain significance Single submitter
All CLIC3 variants
Uncertain significance 37
- p.Ala151Val Single submitter ⚠
- p.Ala188Thr Single submitter ⚠
- p.Ala209Thr Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg200His Single submitter ⚠
- p.Arg204Ser Single submitter ⚠
- p.Arg27Gln Single submitter ⚠
- p.Cys22Tyr Single submitter ⚠
- p.Glu125Gly Single submitter ⚠
- p.Glu198Lys Single submitter ⚠
- p.Gly105Ser Single submitter ⚠
- p.His189Gln Single submitter ⚠
- p.Ile116Leu Single submitter ⚠
- p.Leu142Pro Single submitter ⚠
- p.Leu176Pro Single submitter ⚠
- p.Leu180Met Single submitter ⚠
- p.Leu62Arg Single submitter ⚠
- p.Lys35Asn Single submitter ⚠
- p.Lys54Arg Single submitter ⚠
- p.Phe115Tyr Single submitter ⚠
- p.Phe91Ile Single submitter ⚠
- p.Pro178Leu Single submitter ⚠
- p.Pro220Thr Single submitter ⚠
- p.Pro231Ser Single submitter ⚠
- p.Pro88Leu Single submitter ⚠
- p.Ser175Arg Single submitter ⚠
- p.Ser18Arg Single submitter ⚠
- p.Thr170Met Single submitter ⚠
- p.Thr85Lys Single submitter ⚠
- p.Tyr217His Single submitter ⚠
- p.Val186Ala Single submitter ⚠
- p.Val19Glu Single submitter ⚠
- p.Val19Met Single submitter ⚠
- p.Val202Leu Single submitter ⚠
- p.Val233Met Single submitter ⚠
- p.Val37Ala Single submitter ⚠