CLIC6 — 167 ClinVar variants

All ClinVar germline CLIC6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 139 flagged for review →

10 Benign · 21 Likely benign · 136 Uncertain significance

Full CLIC6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 139

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 61

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 78

The independent predictors disagree with each other — read with care.

All CLIC6 variants

Benign 10

p.Arg436Pro Multiple submitters
p.Arg640Lys Multiple submitters
p.Asp616= Multiple submitters
p.Ile651Val Multiple submitters
p.Ser550= Multiple submitters
p.Thr667= Multiple submitters
p.Val180Leu Multiple submitters ⚠
p.Arg374Leu Single submitter
p.Asp438Glu Single submitter
p.Gly263_Ala272del Single submitter

Likely benign 21

p.Glu401= Multiple submitters
p.Ala262= Single submitter
p.Ala330Pro Single submitter
p.Ala350Ser Single submitter
p.Arg245= Single submitter
p.Arg290His Single submitter ⚠
p.Arg291Gly Single submitter
p.Arg445Gly Single submitter
p.Arg67Gly Single submitter
p.Asp370Glu Single submitter
p.Glu261= Single submitter
p.Gly104Ser Single submitter ⚠
p.Gly157= Single submitter
p.Gly177= Single submitter
p.Gly217= Single submitter
p.Gly263= Single submitter
p.Gly43Ala Single submitter
p.Ile311Thr Single submitter
p.Leu475= Single submitter
p.Ser342= Single submitter
p.Val180= Single submitter

Uncertain significance 136

p.Ala11Val Single submitter ⚠
p.Ala141Thr Single submitter ⚠
p.Ala192Glu Single submitter ⚠
p.Ala222Gly Single submitter ⚠
p.Ala222Thr Single submitter ⚠
p.Ala232Thr Single submitter ⚠
p.Ala276Gly Single submitter ⚠
p.Ala289Pro Single submitter ⚠
p.Ala2Pro Single submitter ⚠
p.Ala315Thr Single submitter ⚠
p.Ala327Thr Single submitter ⚠
p.Ala406Val Single submitter ⚠
p.Ala498Thr Single submitter ⚠
p.Ala4Gly Single submitter ⚠
p.Ala60Ser Single submitter ⚠
p.Ala658Val Single submitter ⚠
p.Ala73Ser Single submitter ⚠
p.Arg245Gln Single submitter ⚠
p.Arg245Trp Single submitter ⚠
p.Arg291Trp Single submitter ⚠
p.Arg351Met Single submitter ⚠
p.Arg373Ile Single submitter ⚠
p.Arg52Lys Single submitter ⚠
p.Arg52Met Single submitter ⚠
p.Arg77Thr Single submitter ⚠
p.Asp191Glu Single submitter ⚠
p.Asp228Asn Single submitter ⚠
p.Asp231Glu Single submitter ⚠
p.Asp238Asn Single submitter ⚠
p.Asp241Gly Single submitter ⚠
p.Asp268Glu Single submitter ⚠
p.Asp452Val Single submitter ⚠
p.Asp499His Single submitter ⚠
p.Asp680Glu Single submitter ⚠
p.Cys469Arg Single submitter ⚠
p.Gln449Arg Single submitter ⚠
p.Glu101Lys Single submitter ⚠
p.Glu120Lys Single submitter ⚠
p.Glu139Lys Single submitter ⚠
p.Glu149Lys Single submitter ⚠
p.Glu171Gln Single submitter ⚠
p.Glu203Asp Single submitter ⚠
p.Glu223Lys Single submitter ⚠
p.Glu251Asp Single submitter ⚠
p.Glu251Lys Single submitter ⚠
p.Glu271Val Single submitter ⚠
p.Glu283Asp Single submitter ⚠
p.Glu283Lys Single submitter ⚠
p.Glu309Lys Single submitter ⚠
p.Glu30Val Single submitter ⚠
p.Glu312Lys Single submitter ⚠
p.Glu317Asp Single submitter ⚠
p.Glu401Gly Single submitter ⚠
p.Glu428Lys Single submitter ⚠
p.Glu443Lys Single submitter ⚠
p.Glu45Gln Single submitter ⚠
p.Glu596Lys Single submitter ⚠
p.Glu617Asp Single submitter ⚠
p.Glu617Gly Single submitter ⚠
p.Glu617Lys Single submitter ⚠
p.Glu82Lys Single submitter ⚠
p.Glu94Gly Single submitter ⚠
p.Gly13Asp Single submitter ⚠
p.Gly150Ser Single submitter ⚠
p.Gly154Ala Single submitter ⚠
p.Gly174Ser Single submitter ⚠
p.Gly277Val Single submitter ⚠
p.Gly287Arg Single submitter ⚠
p.Gly29Arg Single submitter ⚠
p.Gly300Glu Single submitter ⚠
p.Gly324Asp Single submitter ⚠
p.Gly36Arg Single submitter ⚠
p.Gly425Ser Single submitter ⚠
p.Gly506Arg Single submitter ⚠
p.Gly615Arg Single submitter ⚠
p.Gly650Asp Single submitter ⚠
p.Gly75Asp Single submitter ⚠
p.Gly81Ser Single submitter ⚠
p.Gly88Val Single submitter ⚠
p.His545Arg Single submitter ⚠
p.Ile170Met Single submitter ⚠
p.Ile563Val Single submitter ⚠
p.Ile597Met Single submitter ⚠
p.Ile651Phe Single submitter ⚠
p.Ile674Thr Single submitter ⚠
p.Leu206Met Single submitter ⚠
p.Leu481Gln Single submitter ⚠
p.Lys540Met Single submitter ⚠
p.Lys637Arg Single submitter ⚠
p.Met280Leu Single submitter ⚠
p.Met280Val Single submitter ⚠
p.Pro113Ser Single submitter ⚠
p.Pro121His Single submitter ⚠
p.Pro175Ser Single submitter ⚠
p.Pro17Leu Single submitter ⚠
p.Pro18Leu Single submitter ⚠
p.Pro265Arg Single submitter ⚠
p.Pro337Arg Single submitter ⚠
p.Pro378Gln Single submitter ⚠
p.Pro470Gln Single submitter ⚠
p.Pro509Arg Single submitter ⚠
p.Pro536Leu Single submitter ⚠
p.Pro546Leu Single submitter ⚠
p.Pro592Thr Single submitter ⚠
p.Pro90Ser Single submitter ⚠
p.Ser159Asn Single submitter ⚠
p.Ser179Asn Single submitter ⚠
p.Ser219Arg Single submitter ⚠
p.Ser219Gly Single submitter ⚠
p.Ser249Arg Single submitter ⚠
p.Ser279Asn Single submitter ⚠
p.Ser342Phe Single submitter ⚠
p.Ser377Arg Single submitter ⚠
p.Ser397Arg Single submitter ⚠
p.Ser548Thr Single submitter ⚠
p.Thr520Met Single submitter ⚠
p.Thr566Met Single submitter ⚠
p.Thr619Met Single submitter ⚠
p.Thr649Ala Single submitter ⚠
p.Thr667Met Single submitter ⚠
p.Thr76Lys Single submitter ⚠
p.Thr76Met Single submitter ⚠
p.Thr83Ile Single submitter ⚠
p.Tyr659Cys Single submitter ⚠
p.Val220Ala Single submitter ⚠
p.Val226Leu Single submitter ⚠
p.Val230Ile Single submitter ⚠
p.Val240Ala Single submitter ⚠
p.Val292Leu Single submitter ⚠
p.Val484Ile Single submitter ⚠
p.Val555Met Single submitter ⚠
p.Val635Ala Single submitter ⚠
p.Val681Ala Single submitter ⚠
p.Val95Met Single submitter ⚠
p.Gly214Val No assertion criteria sellar metastasis from primary bronchial carcinoid tumor ⚠
p.Gly263Arg No assertion criteria myoepithelial tumor ⚠