CLINT1 — 85 ClinVar variants
All ClinVar germline CLINT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
2 Likely benign · 83 Uncertain significance
Full CLINT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLINT1 p.Ala354Ser Uncertain significance Single submitter
- CLINT1 p.Ala400Val Uncertain significance Single submitter
- CLINT1 p.Ala432Val Uncertain significance Single submitter
- CLINT1 p.Arg102Gly Uncertain significance Single submitter
- CLINT1 p.Arg220Gln Uncertain significance Single submitter
- CLINT1 p.Arg230Gly Uncertain significance Single submitter
- CLINT1 p.Arg244Thr Uncertain significance Single submitter
- CLINT1 p.Arg277His Uncertain significance Single submitter
- CLINT1 p.Arg538Gln Uncertain significance Single submitter
- CLINT1 p.Asn16Ser Uncertain significance Single submitter
- CLINT1 p.Asn511Thr Uncertain significance Single submitter
- CLINT1 p.Asn542Ser Uncertain significance Single submitter
- CLINT1 p.Asp141Asn Uncertain significance Single submitter
- CLINT1 p.Gly578Cys Uncertain significance Single submitter
- CLINT1 p.Gly594Ser Uncertain significance Single submitter
- CLINT1 p.His275Gln Uncertain significance Single submitter
- CLINT1 p.His292Arg Uncertain significance Single submitter
- CLINT1 p.His307Pro Uncertain significance Single submitter
- CLINT1 p.Leu566Phe Uncertain significance Single submitter
- CLINT1 p.Leu60Phe Uncertain significance Single submitter
- CLINT1 p.Leu89Val Uncertain significance Single submitter
- CLINT1 p.Lys190Thr Uncertain significance Single submitter
- CLINT1 p.Lys238Glu Uncertain significance Single submitter
- CLINT1 p.Lys297Glu Uncertain significance Single submitter
- CLINT1 p.Met444Val Uncertain significance Single submitter
- CLINT1 p.Met456Val Uncertain significance Single submitter
- CLINT1 p.Met464Thr Uncertain significance Single submitter
- CLINT1 p.Met493Val Uncertain significance Single submitter
- CLINT1 p.Met4Leu Uncertain significance Single submitter
- CLINT1 p.Met506Ile Uncertain significance Single submitter
- CLINT1 p.Phe116Leu Uncertain significance Single submitter
- CLINT1 p.Phe250Tyr Uncertain significance Single submitter
- CLINT1 p.Phe347Val Uncertain significance Single submitter
- CLINT1 p.Phe372Leu Uncertain significance Single submitter
- CLINT1 p.Pro413Ala Uncertain significance Single submitter
- CLINT1 p.Pro415Ala Uncertain significance Single submitter
- CLINT1 p.Pro491Ser Uncertain significance Single submitter
- CLINT1 p.Pro570Ser Uncertain significance Single submitter
- CLINT1 p.Ser316Pro Uncertain significance Single submitter
- CLINT1 p.Ser478Phe Uncertain significance Single submitter
- CLINT1 p.Ser532Thr Uncertain significance Single submitter
- CLINT1 p.Thr364Ser Uncertain significance Single submitter
- CLINT1 p.Thr447Pro Uncertain significance Single submitter
- CLINT1 p.Thr593Ala Uncertain significance Single submitter
- CLINT1 p.Tyr88Asn Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- CLINT1 p.Ala381Asp Uncertain significance Single submitter
- CLINT1 p.Ala621Thr Uncertain significance Single submitter
- CLINT1 p.Ala621Val Uncertain significance Single submitter
- CLINT1 p.Asn602Lys Uncertain significance Single submitter
- CLINT1 p.Asp189Gly Uncertain significance Single submitter
- CLINT1 p.Asp214Asn Uncertain significance Single submitter
- CLINT1 p.Asp235Asn Uncertain significance Single submitter
- CLINT1 p.Asp325Glu Uncertain significance Single submitter
- CLINT1 p.Asp34Asn Uncertain significance Single submitter
- CLINT1 p.Gln438Arg Uncertain significance Single submitter
- CLINT1 p.Gly346Arg Uncertain significance Single submitter
- CLINT1 p.Gly368Glu Uncertain significance Single submitter
- CLINT1 p.Gly591Ser Uncertain significance Single submitter
- CLINT1 p.His120Arg Uncertain significance Single submitter
- CLINT1 p.Leu489Val Uncertain significance Single submitter
- CLINT1 p.Leu84Val Uncertain significance Single submitter
- CLINT1 p.Lys200Glu Uncertain significance Single submitter
- CLINT1 p.Met512Ile Uncertain significance Single submitter
- CLINT1 p.Met549Val Uncertain significance Single submitter
- CLINT1 p.Met557Leu Uncertain significance Single submitter
- CLINT1 p.Met581Val Uncertain significance Single submitter
- CLINT1 p.Met596Val Uncertain significance Single submitter
- CLINT1 p.Pro246Leu Uncertain significance Single submitter
- CLINT1 p.Pro570Leu Uncertain significance Single submitter
- CLINT1 p.Ser193Arg Uncertain significance Single submitter
- CLINT1 p.Ser245Phe Uncertain significance Single submitter
- CLINT1 p.Ser430Phe Uncertain significance Single submitter
- CLINT1 p.Thr211Ala Uncertain significance Single submitter
- CLINT1 p.Thr306Ile Uncertain significance Single submitter
- CLINT1 p.Thr366Lys Uncertain significance Single submitter
- CLINT1 p.Thr569Ser Uncertain significance Single submitter
- CLINT1 p.Val167Ala Uncertain significance Single submitter
- CLINT1 p.Val79Ile Uncertain significance Single submitter
All CLINT1 variants
Likely benign 2
- p.Ala587Thr Single submitter
- p.Asn555Ser Single submitter
Uncertain significance 83
- c.1381-12C>G Single submitter
- c.1381-15C>A Single submitter
- c.1381-16T>A Single submitter
- c.1381-53C>T Single submitter
- c.1381-8A>G Single submitter
- p.Ala354Ser Single submitter ⚠
- p.Ala381Asp Single submitter ⚠
- p.Ala400Val Single submitter ⚠
- p.Ala432Val Single submitter ⚠
- p.Ala621Thr Single submitter ⚠
- p.Ala621Val Single submitter ⚠
- p.Arg102Gly Single submitter ⚠
- p.Arg220Gln Single submitter ⚠
- p.Arg230Gly Single submitter ⚠
- p.Arg244Thr Single submitter ⚠
- p.Arg277His Single submitter ⚠
- p.Arg538Gln Single submitter ⚠
- p.Asn16Ser Single submitter ⚠
- p.Asn511Thr Single submitter ⚠
- p.Asn542Ser Single submitter ⚠
- p.Asn602Lys Single submitter ⚠
- p.Asp141Asn Single submitter ⚠
- p.Asp189Gly Single submitter ⚠
- p.Asp214Asn Single submitter ⚠
- p.Asp235Asn Single submitter ⚠
- p.Asp325Glu Single submitter ⚠
- p.Asp34Asn Single submitter ⚠
- p.Gln438Arg Single submitter ⚠
- p.Gly346Arg Single submitter ⚠
- p.Gly368Glu Single submitter ⚠
- p.Gly578Cys Single submitter ⚠
- p.Gly591Ser Single submitter ⚠
- p.Gly594Ser Single submitter ⚠
- p.His120Arg Single submitter ⚠
- p.His275Gln Single submitter ⚠
- p.His292Arg Single submitter ⚠
- p.His307Pro Single submitter ⚠
- p.Leu489Val Single submitter ⚠
- p.Leu566Phe Single submitter ⚠
- p.Leu60Phe Single submitter ⚠
- p.Leu84Val Single submitter ⚠
- p.Leu89Val Single submitter ⚠
- p.Lys190Thr Single submitter ⚠
- p.Lys200Glu Single submitter ⚠
- p.Lys238Glu Single submitter ⚠
- p.Lys297Glu Single submitter ⚠
- p.Met444Val Single submitter ⚠
- p.Met456Val Single submitter ⚠
- p.Met464Thr Single submitter ⚠
- p.Met493Val Single submitter ⚠
- p.Met4Leu Single submitter ⚠
- p.Met506Ile Single submitter ⚠
- p.Met512Ile Single submitter ⚠
- p.Met549Val Single submitter ⚠
- p.Met557Leu Single submitter ⚠
- p.Met581Val Single submitter ⚠
- p.Met596Val Single submitter ⚠
- p.Phe116Leu Single submitter ⚠
- p.Phe250Tyr Single submitter ⚠
- p.Phe347Val Single submitter ⚠
- p.Phe372Leu Single submitter ⚠
- p.Pro246Leu Single submitter ⚠
- p.Pro413Ala Single submitter ⚠
- p.Pro415Ala Single submitter ⚠
- p.Pro491Ser Single submitter ⚠
- p.Pro570Leu Single submitter ⚠
- p.Pro570Ser Single submitter ⚠
- p.Ser193Arg Single submitter ⚠
- p.Ser245Phe Single submitter ⚠
- p.Ser316Pro Single submitter ⚠
- p.Ser430Phe Single submitter ⚠
- p.Ser478Phe Single submitter ⚠
- p.Ser532Thr Single submitter ⚠
- p.Thr211Ala Single submitter ⚠
- p.Thr306Ile Single submitter ⚠
- p.Thr364Ser Single submitter ⚠
- p.Thr366Lys Single submitter ⚠
- p.Thr447Pro Single submitter ⚠
- p.Thr569Ser Single submitter ⚠
- p.Thr593Ala Single submitter ⚠
- p.Tyr88Asn Single submitter ⚠
- p.Val167Ala Single submitter ⚠
- p.Val79Ile Single submitter ⚠