CLIP1 — 210 ClinVar variants
All ClinVar germline CLIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 164 flagged for review →
1 Pathogenic · 2 Conflicting · 8 Benign · 1 Benign/Likely benign · 31 Likely benign · 167 Uncertain significance
Full CLIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 164
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 90
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLIP1 p.Ala142Val Uncertain significance Multiple submitters
- CLIP1 p.Arg342Cys Uncertain significance Multiple submitters
- CLIP1 p.Ala1088Glu Uncertain significance Single submitter
- CLIP1 p.Ala1088Val Uncertain significance Single submitter
- CLIP1 p.Ala142Thr Uncertain significance Single submitter
- CLIP1 p.Ala313Thr Uncertain significance Single submitter
- CLIP1 p.Ala323Ser Uncertain significance Single submitter
- CLIP1 p.Ala344Thr Uncertain significance Single submitter
- CLIP1 p.Ala376Val Uncertain significance Single submitter
- CLIP1 p.Ala42Gly Uncertain significance Single submitter
- CLIP1 p.Ala632Thr Uncertain significance Single submitter
- CLIP1 p.Ala694Ser Uncertain significance Single submitter
- CLIP1 p.Ala694Thr Uncertain significance Single submitter
- CLIP1 p.Ala738Ser Uncertain significance Single submitter
- CLIP1 p.Arg144Gln Uncertain significance Single submitter
- CLIP1 p.Arg144Pro Uncertain significance Single submitter
- CLIP1 p.Arg229Trp Uncertain significance Single submitter
- CLIP1 p.Arg530Gln Uncertain significance Single submitter
- CLIP1 p.Arg952Leu Uncertain significance Single submitter
- CLIP1 p.Asn1020Ser Uncertain significance Single submitter
- CLIP1 p.Asn1138Lys Uncertain significance Single submitter
- CLIP1 p.Asn1297Ser Uncertain significance Single submitter
- CLIP1 p.Asn135Ser Uncertain significance Single submitter
- CLIP1 p.Asn294Lys Uncertain significance Single submitter
- CLIP1 p.Asn536Lys Uncertain significance Single submitter
- CLIP1 p.Asn536Ser Uncertain significance Single submitter
- CLIP1 p.Asp100Asn Uncertain significance Single submitter
- CLIP1 p.Asp132Asn Uncertain significance Single submitter
- CLIP1 p.Asp397Asn Uncertain significance Single submitter
- CLIP1 p.Asp718Glu Uncertain significance Single submitter
- CLIP1 p.Glu1314Asp Uncertain significance Single submitter
- CLIP1 p.Glu1420Val Uncertain significance Single submitter
- CLIP1 p.Glu652Gly Uncertain significance Single submitter
- CLIP1 p.Gly226Cys Uncertain significance Single submitter
- CLIP1 p.Gly239Arg Uncertain significance Single submitter
- CLIP1 p.Gly259Ala Uncertain significance Single submitter
- CLIP1 p.Gly398Arg Uncertain significance Single submitter
- CLIP1 p.His1019Arg Uncertain significance Single submitter
- CLIP1 p.His576Arg Uncertain significance Single submitter
- CLIP1 p.Ile117Val Uncertain significance Single submitter
- CLIP1 p.Ile1237Leu Uncertain significance Single submitter
- CLIP1 p.Ile1421Met Uncertain significance Single submitter
- CLIP1 p.Ile15Met Uncertain significance Single submitter
-
CLIP1 p.Ile461Val
Uncertain significance
Single submitter
CLIP1-related intellectual disability
- CLIP1 p.Ile588Leu Uncertain significance Single submitter
- CLIP1 p.Ile620Thr Uncertain significance Single submitter
- CLIP1 p.Ile620Val Uncertain significance Single submitter
- CLIP1 p.Ile631Val Uncertain significance Single submitter
- CLIP1 p.Ile713Thr Uncertain significance Single submitter
- CLIP1 p.Leu1333Pro Uncertain significance Single submitter
- CLIP1 p.Leu271Ser Uncertain significance Single submitter
- CLIP1 p.Leu428Val Uncertain significance Single submitter
- CLIP1 p.Leu717Pro Uncertain significance Single submitter
- CLIP1 p.Lys1336Arg Uncertain significance Single submitter
-
CLIP1 p.Lys1373Arg
Uncertain significance
Single submitter
CLIP1-related intellectual disability
- CLIP1 p.Lys177Arg Uncertain significance Single submitter
- CLIP1 p.Lys268Glu Uncertain significance Single submitter
- CLIP1 p.Lys586Glu Uncertain significance Single submitter
- CLIP1 p.Lys996Arg Uncertain significance Single submitter
- CLIP1 p.Met1342Ile Uncertain significance Single submitter
- CLIP1 p.Met1346Leu Uncertain significance Single submitter
- CLIP1 p.Met3Val Uncertain significance Single submitter
- CLIP1 p.Met638Leu Uncertain significance Single submitter
- CLIP1 p.Met934Arg Uncertain significance Single submitter
- CLIP1 p.Met947Arg Uncertain significance Single submitter
- CLIP1 p.Met947Val Uncertain significance Single submitter
- CLIP1 p.Phe230Cys Uncertain significance Single submitter
- CLIP1 p.Phe58Tyr Uncertain significance Single submitter
- CLIP1 p.Phe974Leu Uncertain significance Single submitter
- CLIP1 p.Pro1394Arg Uncertain significance Single submitter
- CLIP1 p.Pro179Ser Uncertain significance Single submitter
- CLIP1 p.Ser1303Thr Uncertain significance Single submitter
- CLIP1 p.Ser285Phe Uncertain significance Single submitter
- CLIP1 p.Ser816Thr Uncertain significance Single submitter
- CLIP1 p.Thr1033Ile Uncertain significance Single submitter
- CLIP1 p.Thr1033Ser Uncertain significance Single submitter
- CLIP1 p.Thr1036Ala Uncertain significance Single submitter
- CLIP1 p.Thr1038Ser Uncertain significance Single submitter
- CLIP1 p.Thr1430Ser Uncertain significance Single submitter
- CLIP1 p.Thr234Ser Uncertain significance Single submitter
- CLIP1 p.Thr303Ala Uncertain significance Single submitter
- CLIP1 p.Thr595Met Uncertain significance Single submitter
- CLIP1 p.Thr822Ala Uncertain significance Single submitter
- CLIP1 p.Val1146Ile Uncertain significance Single submitter
- CLIP1 p.Val299Ala Uncertain significance Single submitter
- CLIP1 p.Val385Met Uncertain significance Single submitter
- CLIP1 p.Val60Phe Uncertain significance Single submitter
- CLIP1 p.Val726Ile Uncertain significance Single submitter
- CLIP1 p.Val91Ile Uncertain significance Single submitter
- CLIP1 p.Val958Leu Uncertain significance Single submitter
Predictors split 74
The independent predictors disagree with each other — read with care.
- CLIP1 p.Gly1356Arg Uncertain significance Multiple submitters
-
CLIP1 p.Lys1267Arg
Uncertain significance
Multiple submitters
CLIP1-related intellectual disability
- CLIP1 p.Ala202Pro Likely benign Single submitter
- CLIP1 p.Ala369Val Uncertain significance Single submitter
- CLIP1 p.Ala986Gly Uncertain significance Single submitter
- CLIP1 p.Arg1062Trp Uncertain significance Single submitter
- CLIP1 p.Arg107Gln Uncertain significance Single submitter
- CLIP1 p.Arg298Gln Uncertain significance Single submitter
- CLIP1 p.Arg309Cys Uncertain significance Single submitter
- CLIP1 p.Arg396Gln Uncertain significance Single submitter
- CLIP1 p.Arg396Gly Uncertain significance Single submitter
- CLIP1 p.Arg444Gln Uncertain significance Single submitter
- CLIP1 p.Arg476Cys Uncertain significance Single submitter
- CLIP1 p.Arg563Cys Uncertain significance Single submitter
- CLIP1 p.Arg780Trp Conflicting Single submitter
- CLIP1 p.Asp949Asn Uncertain significance Single submitter
- CLIP1 p.Gln524Arg Uncertain significance Single submitter
- CLIP1 p.Gln681Glu Uncertain significance Single submitter
- CLIP1 p.Gln871Glu Uncertain significance Single submitter
- CLIP1 p.Glu1142Lys Uncertain significance Single submitter
- CLIP1 p.Glu1147Asp Uncertain significance Single submitter
- CLIP1 p.Glu1368Lys Uncertain significance Single submitter
- CLIP1 p.Glu52Lys Uncertain significance Single submitter
- CLIP1 p.Glu534Lys Uncertain significance Single submitter
- CLIP1 p.Glu639Ala Uncertain significance Single submitter
- CLIP1 p.Glu673Lys Uncertain significance Single submitter
- CLIP1 p.Glu801Ala Uncertain significance Single submitter
- CLIP1 p.Glu814Gly Uncertain significance Single submitter
- CLIP1 p.Glu824Ala Uncertain significance Single submitter
- CLIP1 p.Glu829Gln Uncertain significance Single submitter
- CLIP1 p.Glu829Lys Uncertain significance Single submitter
- CLIP1 p.Glu850Gly Uncertain significance Single submitter
- CLIP1 p.Glu916Gln Uncertain significance Single submitter
- CLIP1 p.Glu992Gln Uncertain significance Single submitter
- CLIP1 p.His1040Tyr Uncertain significance Single submitter
- CLIP1 p.His1409Arg Uncertain significance Single submitter
- CLIP1 p.Ile1323Phe Uncertain significance Single submitter
- CLIP1 p.Ile167Phe Uncertain significance Single submitter
- CLIP1 p.Ile570Met Uncertain significance Single submitter
- CLIP1 p.Ile588Thr Uncertain significance Single submitter
- CLIP1 p.Ile930Thr Uncertain significance Single submitter
- CLIP1 p.Leu1161Arg Uncertain significance Single submitter
- CLIP1 p.Leu149Met Uncertain significance Single submitter
- CLIP1 p.Leu573Val Uncertain significance Single submitter
- CLIP1 p.Leu891Arg Uncertain significance Single submitter
- CLIP1 p.Leu9Phe Uncertain significance Single submitter
- CLIP1 p.Lys743Asn Uncertain significance Single submitter
- CLIP1 p.Lys912Thr Uncertain significance Single submitter
- CLIP1 p.Lys923Asn Uncertain significance Single submitter
- CLIP1 p.Lys925Asn Uncertain significance Single submitter
- CLIP1 p.Lys964Glu Uncertain significance Single submitter
- CLIP1 p.Lys985Ile Uncertain significance Single submitter
- CLIP1 p.Met410Ile Uncertain significance Single submitter
- CLIP1 p.Met513Ile Uncertain significance Single submitter
- CLIP1 p.Met666Arg Uncertain significance Single submitter
- CLIP1 p.Met874Thr Uncertain significance Single submitter
- CLIP1 p.Phe486Leu Uncertain significance Single submitter
- CLIP1 p.Phe762Ser Uncertain significance Single submitter
- CLIP1 p.Pro113Thr Uncertain significance Single submitter
- CLIP1 p.Ser1236Arg Uncertain significance Single submitter
- CLIP1 p.Ser327Asn Uncertain significance Single submitter
- CLIP1 p.Ser383Asn Uncertain significance Single submitter
- CLIP1 p.Ser44Gly Uncertain significance Single submitter
- CLIP1 p.Ser48Tyr Uncertain significance Single submitter
- CLIP1 p.Ser554Tyr Uncertain significance Single submitter
- CLIP1 p.Ser646Arg Uncertain significance Single submitter
- CLIP1 p.Thr1050Met Likely benign Single submitter
- CLIP1 p.Thr153Met Uncertain significance Single submitter
- CLIP1 p.Thr182Met Uncertain significance Single submitter
- CLIP1 p.Thr653Met Uncertain significance Single submitter
- CLIP1 p.Thr731Arg Uncertain significance Single submitter
- CLIP1 p.Thr833Ile Uncertain significance Single submitter
-
CLIP1 p.Gln1120His
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
-
CLIP1 p.Thr27Met
Benign
No assertion criteria
CLIP1-related disorder
All CLIP1 variants
Pathogenic 1
- p.Arg144Ter No assertion criteria Short stature
Conflicting classifications of pathogenicity 2
- p.Arg780Trp Single submitter ⚠
- p.Lys857= Single submitter
Benign 8
- p.Ala301= Multiple submitters
- p.Ser102= Multiple submitters
- c.3967-11dup Single submitter
- p.Ala237= Single submitter
- p.Gln457= Single submitter
- p.Gly1060= Single submitter
- p.Thr1308= Single submitter
- p.Thr27Met No assertion criteria CLIP1-related disorder ⚠
Benign/Likely benign 1
- p.Asn99= Multiple submitters
Likely benign 31
- p.Ala1224Ser Multiple submitters
- p.Lys851= Multiple submitters
- c.3916+9C>T Single submitter
- p.Ala1085= Single submitter
- p.Ala1088= Single submitter
- p.Ala202Pro Single submitter ⚠
- p.Ala903Thr Single submitter
- p.Arg1062Gln Single submitter
- p.Arg780Gln Single submitter
- p.Asn812= Single submitter
- p.Asp957Asn Single submitter
- p.Gln1048Arg Single submitter
- p.Glu387= Single submitter
- p.Glu528= Single submitter
- p.Leu1276= Single submitter
- p.Leu1283= Single submitter
- p.Leu849= Single submitter
- p.Pro538= Single submitter
- p.Ser1009Leu Single submitter
- p.Ser1189= Single submitter
- p.Thr1050Met Single submitter ⚠
- p.Thr1112= Single submitter
- p.Thr27= Single submitter
- p.Thr303= Single submitter
- p.Thr593Ala Single submitter
- p.Val385= Single submitter
- p.Ala1174= No assertion criteria CLIP1-related disorder
- p.Asn1263= No assertion criteria CLIP1-related disorder
- p.Gln1120His No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
- p.Ile631= No assertion criteria CLIP1-related disorder
- p.Thr339= No assertion criteria CLIP1-related disorder
Uncertain significance 167
- p.Ala142Val Multiple submitters ⚠
- p.Arg342Cys Multiple submitters ⚠
- p.Gly1356Arg Multiple submitters ⚠
- p.Lys1267Arg Multiple submitters CLIP1-related intellectual disability ⚠
- c.1204-3C>T Single submitter
- c.2451+1G>T Single submitter
- c.3249+10G>A Single submitter
- p.Ala1088Glu Single submitter ⚠
- p.Ala1088Val Single submitter ⚠
- p.Ala142Thr Single submitter ⚠
- p.Ala313Thr Single submitter ⚠
- p.Ala323Ser Single submitter ⚠
- p.Ala344Thr Single submitter ⚠
- p.Ala369Val Single submitter ⚠
- p.Ala376Val Single submitter ⚠
- p.Ala42Gly Single submitter ⚠
- p.Ala632Thr Single submitter ⚠
- p.Ala694Ser Single submitter ⚠
- p.Ala694Thr Single submitter ⚠
- p.Ala738Ser Single submitter ⚠
- p.Ala986Gly Single submitter ⚠
- p.Arg1062Trp Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg144Pro Single submitter ⚠
- p.Arg229Trp Single submitter ⚠
- p.Arg298Gln Single submitter ⚠
- p.Arg309Cys Single submitter ⚠
- p.Arg396Gln Single submitter ⚠
- p.Arg396Gly Single submitter ⚠
- p.Arg444Gln Single submitter ⚠
- p.Arg476Cys Single submitter ⚠
- p.Arg530Gln Single submitter ⚠
- p.Arg563Cys Single submitter ⚠
- p.Arg952Leu Single submitter ⚠
- p.Asn1020Ser Single submitter ⚠
- p.Asn1138Lys Single submitter ⚠
- p.Asn1297Ser Single submitter ⚠
- p.Asn135Ser Single submitter ⚠
- p.Asn294Lys Single submitter ⚠
- p.Asn536Lys Single submitter ⚠
- p.Asn536Ser Single submitter ⚠
- p.Asp100Asn Single submitter ⚠
- p.Asp132Asn Single submitter ⚠
- p.Asp397Asn Single submitter ⚠
- p.Asp718Glu Single submitter ⚠
- p.Asp949Asn Single submitter ⚠
- p.Gln524Arg Single submitter ⚠
- p.Gln681Glu Single submitter ⚠
- p.Gln871Glu Single submitter ⚠
- p.Glu1142Lys Single submitter ⚠
- p.Glu1147Asp Single submitter ⚠
- p.Glu1314Asp Single submitter ⚠
- p.Glu1368Lys Single submitter ⚠
- p.Glu1420Val Single submitter ⚠
- p.Glu52Lys Single submitter ⚠
- p.Glu534Lys Single submitter ⚠
- p.Glu639Ala Single submitter ⚠
- p.Glu652Gly Single submitter ⚠
- p.Glu673Lys Single submitter ⚠
- p.Glu801Ala Single submitter ⚠
- p.Glu814Gly Single submitter ⚠
- p.Glu824Ala Single submitter ⚠
- p.Glu829Gln Single submitter ⚠
- p.Glu829Lys Single submitter ⚠
- p.Glu850Gly Single submitter ⚠
- p.Glu916Gln Single submitter ⚠
- p.Glu992Gln Single submitter ⚠
- p.Gly226Cys Single submitter ⚠
- p.Gly239Arg Single submitter ⚠
- p.Gly259Ala Single submitter ⚠
- p.Gly398Arg Single submitter ⚠
- p.His1019Arg Single submitter ⚠
- p.His1040Tyr Single submitter ⚠
- p.His1409Arg Single submitter ⚠
- p.His576Arg Single submitter ⚠
- p.Ile117Val Single submitter ⚠
- p.Ile1237Leu Single submitter ⚠
- p.Ile1323Phe Single submitter ⚠
- p.Ile1421Met Single submitter ⚠
- p.Ile15Met Single submitter ⚠
- p.Ile167Phe Single submitter ⚠
- p.Ile461Val Single submitter CLIP1-related intellectual disability ⚠
- p.Ile570Met Single submitter ⚠
- p.Ile588Leu Single submitter ⚠
- p.Ile588Thr Single submitter ⚠
- p.Ile620Thr Single submitter ⚠
- p.Ile620Val Single submitter ⚠
- p.Ile631Val Single submitter ⚠
- p.Ile713Thr Single submitter ⚠
- p.Ile930Thr Single submitter ⚠
- p.Leu1161Arg Single submitter ⚠
- p.Leu1333Pro Single submitter ⚠
- p.Leu149Met Single submitter ⚠
- p.Leu271Ser Single submitter ⚠
- p.Leu428Val Single submitter ⚠
- p.Leu573Val Single submitter ⚠
- p.Leu717Pro Single submitter ⚠
- p.Leu891Arg Single submitter ⚠
- p.Leu9Phe Single submitter ⚠
- p.Lys1336Arg Single submitter ⚠
- p.Lys1373Arg Single submitter CLIP1-related intellectual disability ⚠
- p.Lys177Arg Single submitter ⚠
- p.Lys268Glu Single submitter ⚠
- p.Lys586Glu Single submitter ⚠
- p.Lys743= Single submitter
- p.Lys743Asn Single submitter ⚠
- p.Lys912Thr Single submitter ⚠
- p.Lys923Asn Single submitter ⚠
- p.Lys925Asn Single submitter ⚠
- p.Lys964Glu Single submitter ⚠
- p.Lys985Ile Single submitter ⚠
- p.Lys996Arg Single submitter ⚠
- p.Met1342Ile Single submitter ⚠
- p.Met1346Leu Single submitter ⚠
- p.Met3Val Single submitter ⚠
- p.Met410Ile Single submitter ⚠
- p.Met513Ile Single submitter ⚠
- p.Met638Leu Single submitter ⚠
- p.Met666Arg Single submitter ⚠
- p.Met874Thr Single submitter ⚠
- p.Met934Arg Single submitter ⚠
- p.Met947Arg Single submitter ⚠
- p.Met947Val Single submitter ⚠
- p.Phe230Cys Single submitter ⚠
- p.Phe486Leu Single submitter ⚠
- p.Phe58Tyr Single submitter ⚠
- p.Phe762Ser Single submitter ⚠
- p.Phe974Leu Single submitter ⚠
- p.Pro113Thr Single submitter ⚠
- p.Pro1394Arg Single submitter ⚠
- p.Pro179Ser Single submitter ⚠
- p.Ser1236Arg Single submitter ⚠
- p.Ser1303Thr Single submitter ⚠
- p.Ser285Phe Single submitter ⚠
- p.Ser327Asn Single submitter ⚠
- p.Ser383Asn Single submitter ⚠
- p.Ser44Gly Single submitter ⚠
- p.Ser48Tyr Single submitter ⚠
- p.Ser554Tyr Single submitter ⚠
- p.Ser646Arg Single submitter ⚠
- p.Ser816Thr Single submitter ⚠
- p.Thr1033Ile Single submitter ⚠
- p.Thr1033Ser Single submitter ⚠
- p.Thr1036Ala Single submitter ⚠
- p.Thr1038Ser Single submitter ⚠
- p.Thr1430Ser Single submitter ⚠
- p.Thr153Met Single submitter ⚠
- p.Thr182Met Single submitter ⚠
- p.Thr234Ser Single submitter ⚠
- p.Thr303Ala Single submitter ⚠
- p.Thr382= Single submitter
- p.Thr595Met Single submitter ⚠
- p.Thr653Met Single submitter ⚠
- p.Thr731Arg Single submitter ⚠
- p.Thr822Ala Single submitter ⚠
- p.Thr833Ile Single submitter ⚠
- p.Val1146Ile Single submitter ⚠
- p.Val228= Single submitter
- p.Val299Ala Single submitter ⚠
- p.Val385Met Single submitter ⚠
- p.Val60Phe Single submitter ⚠
- p.Val726Ile Single submitter ⚠
- p.Val91Ile Single submitter ⚠
- p.Val958Leu Single submitter ⚠
- p.Gln1021Ter No assertion criteria
- p.Glu387_Ile388insTer No assertion criteria CLIP1-related disorder