CLIP2 — 172 ClinVar variants
All ClinVar germline CLIP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 137 flagged for review →
13 Benign · 3 Benign/Likely benign · 21 Likely benign · 135 Uncertain significance
Full CLIP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 137
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 83
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLIP2 p.Arg12His Uncertain significance Multiple submitters
- CLIP2 p.Ala158Val Uncertain significance Single submitter
- CLIP2 p.Ala166Val Uncertain significance Single submitter
- CLIP2 p.Ala265Val Uncertain significance Single submitter
- CLIP2 p.Ala327Val Uncertain significance Single submitter
- CLIP2 p.Ala348Thr Uncertain significance Single submitter
- CLIP2 p.Ala468Thr Uncertain significance Single submitter
- CLIP2 p.Ala500Ser Uncertain significance Single submitter
- CLIP2 p.Ala539Thr Uncertain significance Single submitter
- CLIP2 p.Ala540Thr Uncertain significance Single submitter
- CLIP2 p.Ala570Thr Uncertain significance Single submitter
- CLIP2 p.Ala651Thr Uncertain significance Single submitter
- CLIP2 p.Ala684Val Uncertain significance Single submitter
- CLIP2 p.Ala746Val Uncertain significance Single submitter
- CLIP2 p.Ala799Thr Uncertain significance Single submitter
- CLIP2 p.Ala919Pro Uncertain significance Single submitter
- CLIP2 p.Ala980Val Uncertain significance Single submitter
- CLIP2 p.Arg128Gly Uncertain significance Single submitter
- CLIP2 p.Arg128Ser Uncertain significance Single submitter
- CLIP2 p.Arg375Gln Uncertain significance Single submitter
- CLIP2 p.Arg425Gln Uncertain significance Single submitter
- CLIP2 p.Arg544Gln Uncertain significance Single submitter
- CLIP2 p.Arg564Gln Uncertain significance Single submitter
- CLIP2 p.Arg715Gln Uncertain significance Single submitter
- CLIP2 p.Arg768Gln Uncertain significance Single submitter
- CLIP2 p.Arg771Gln Uncertain significance Single submitter
- CLIP2 p.Arg921Cys Uncertain significance Single submitter
- CLIP2 p.Arg921His Uncertain significance Single submitter
- CLIP2 p.Arg928Thr Uncertain significance Single submitter
- CLIP2 p.Arg940Gln Uncertain significance Single submitter
- CLIP2 p.Arg985Gln Uncertain significance Single submitter
- CLIP2 p.Asn205Ser Uncertain significance Single submitter
- CLIP2 p.Asn612Thr Uncertain significance Single submitter
- CLIP2 p.Asn920Ser Uncertain significance Single submitter
- CLIP2 p.Asp1044Asn Uncertain significance Single submitter
- CLIP2 p.Asp1044Val Uncertain significance Single submitter
- CLIP2 p.Asp727Asn Uncertain significance Single submitter
- CLIP2 p.Asp739Tyr Uncertain significance Single submitter
- CLIP2 p.Asp929Glu Uncertain significance Single submitter
- CLIP2 p.Asp995Glu Uncertain significance Single submitter
- CLIP2 p.Gln770Arg Uncertain significance Single submitter
- CLIP2 p.Gln804His Uncertain significance Single submitter
- CLIP2 p.Glu189Gln Uncertain significance Single submitter
- CLIP2 p.Glu240Lys Uncertain significance Single submitter
- CLIP2 p.Glu687Lys Uncertain significance Single submitter
- CLIP2 p.Glu963Gln Uncertain significance Single submitter
- CLIP2 p.Gly1032Ser Uncertain significance Single submitter
- CLIP2 p.Gly14Arg Uncertain significance Single submitter
- CLIP2 p.Gly647Ser Uncertain significance Single submitter
- CLIP2 p.Gly6Ser Uncertain significance Single submitter
- CLIP2 p.His671Tyr Uncertain significance Single submitter
- CLIP2 p.Ile138Leu Uncertain significance Single submitter
- CLIP2 p.Ile646Met Uncertain significance Single submitter
- CLIP2 p.Ile646Ser Uncertain significance Single submitter
- CLIP2 p.Ile656Met Uncertain significance Single submitter
- CLIP2 p.Ile819Phe Uncertain significance Single submitter
- CLIP2 p.Leu800Pro Uncertain significance Single submitter
- CLIP2 p.Lys217Arg Uncertain significance Single submitter
- CLIP2 p.Lys580Gln Uncertain significance Single submitter
- CLIP2 p.Lys657Arg Uncertain significance Single submitter
- CLIP2 p.Lys936Arg Uncertain significance Single submitter
- CLIP2 p.Met848Leu Uncertain significance Single submitter
- CLIP2 p.Pro186Ser Uncertain significance Single submitter
- CLIP2 p.Pro19Ser Uncertain significance Single submitter
- CLIP2 p.Pro55Ser Uncertain significance Single submitter
- CLIP2 p.Pro61Arg Uncertain significance Single submitter
- CLIP2 p.Pro61Ser Uncertain significance Single submitter
- CLIP2 p.Pro926Leu Uncertain significance Single submitter
- CLIP2 p.Pro981Ser Uncertain significance Single submitter
- CLIP2 p.Ser182Thr Uncertain significance Single submitter
- CLIP2 p.Ser553Thr Uncertain significance Single submitter
- CLIP2 p.Ser931Asn Uncertain significance Single submitter
- CLIP2 p.Ser979Leu Uncertain significance Single submitter
- CLIP2 p.Thr603Ala Uncertain significance Single submitter
- CLIP2 p.Thr806Ala Uncertain significance Single submitter
- CLIP2 p.Tyr574Cys Uncertain significance Single submitter
- CLIP2 p.Val191Ile Uncertain significance Single submitter
- CLIP2 p.Val238Met Uncertain significance Single submitter
- CLIP2 p.Val308Gly Uncertain significance Single submitter
- CLIP2 p.Val323Ile Uncertain significance Single submitter
- CLIP2 p.Val679Met Uncertain significance Single submitter
- CLIP2 p.Val71Leu Uncertain significance Single submitter
- CLIP2 p.Val780Ile Uncertain significance Single submitter
Predictors split 54
The independent predictors disagree with each other — read with care.
- CLIP2 p.Ala158Pro Uncertain significance Single submitter
- CLIP2 p.Ala33Val Uncertain significance Single submitter
- CLIP2 p.Ala60Val Uncertain significance Single submitter
- CLIP2 p.Arg448His Uncertain significance Single submitter
- CLIP2 p.Arg544Trp Uncertain significance Single submitter
- CLIP2 p.Arg582His Uncertain significance Single submitter
- CLIP2 p.Arg725Cys Likely benign Single submitter
- CLIP2 p.Arg725His Uncertain significance Single submitter
- CLIP2 p.Arg768Trp Benign Single submitter
- CLIP2 p.Arg784Gln Benign Single submitter
- CLIP2 p.Arg784Trp Uncertain significance Single submitter
- CLIP2 p.Arg84Gln Uncertain significance Single submitter
- CLIP2 p.Arg875Trp Uncertain significance Single submitter
- CLIP2 p.Arg876Cys Uncertain significance Single submitter
- CLIP2 p.Arg932Cys Uncertain significance Single submitter
- CLIP2 p.Arg977Trp Uncertain significance Single submitter
- CLIP2 p.Asn193Tyr Uncertain significance Single submitter
- CLIP2 p.Asn205Lys Uncertain significance Single submitter
- CLIP2 p.Asp565Asn Uncertain significance Single submitter
- CLIP2 p.Asp890Glu Uncertain significance Single submitter
- CLIP2 p.Asp976Asn Uncertain significance Single submitter
- CLIP2 p.Gln557Arg Uncertain significance Single submitter
- CLIP2 p.Gln724Pro Uncertain significance Single submitter
- CLIP2 p.Glu559Lys Uncertain significance Single submitter
- CLIP2 p.Glu729Lys Uncertain significance Single submitter
- CLIP2 p.Glu750Lys Likely benign Single submitter
- CLIP2 p.Glu760Gln Uncertain significance Single submitter
- CLIP2 p.Glu760Lys Uncertain significance Single submitter
- CLIP2 p.Glu767Gln Uncertain significance Single submitter
- CLIP2 p.Glu785Lys Uncertain significance Single submitter
- CLIP2 p.Glu857Asp Uncertain significance Single submitter
- CLIP2 p.Glu857Gln Uncertain significance Single submitter
- CLIP2 p.Gly155Arg Uncertain significance Single submitter
- CLIP2 p.Gly26Arg Uncertain significance Single submitter
- CLIP2 p.Gly289Ser Uncertain significance Single submitter
- CLIP2 p.Gly744Asp Uncertain significance Single submitter
- CLIP2 p.His714Gln Uncertain significance Single submitter
- CLIP2 p.Leu545Val Uncertain significance Single submitter
- CLIP2 p.Leu696Met Uncertain significance Single submitter
- CLIP2 p.Lys400Asn Uncertain significance Single submitter
- CLIP2 p.Lys657Met Uncertain significance Single submitter
- CLIP2 p.Pro149Thr Uncertain significance Single submitter
- CLIP2 p.Pro178Arg Uncertain significance Single submitter
- CLIP2 p.Pro534Leu Uncertain significance Single submitter
- CLIP2 p.Ser160Cys Uncertain significance Single submitter
- CLIP2 p.Ser31Leu Uncertain significance Single submitter
- CLIP2 p.Ser42Phe Uncertain significance Single submitter
- CLIP2 p.Ser560Arg Uncertain significance Single submitter
- CLIP2 p.Ser619Leu Uncertain significance Single submitter
- CLIP2 p.Thr175Met Uncertain significance Single submitter
- CLIP2 p.Thr177Met Uncertain significance Single submitter
- CLIP2 p.Thr497Ile Uncertain significance Single submitter
- CLIP2 p.Val161Met Uncertain significance Single submitter
- CLIP2 p.Val234Met Uncertain significance Single submitter
All CLIP2 variants
Benign 13
- p.Ala123= Multiple submitters
- p.Arg932= Multiple submitters
- p.Asn205= Multiple submitters
- p.Ile396= Multiple submitters
- p.Ser52= Multiple submitters
- p.Ala692= Single submitter
- p.Arg768Trp Single submitter ⚠
- p.Arg784Gln Single submitter ⚠
- p.Arg886Gln Single submitter
- p.Asp739= Single submitter
- p.Asp890= Single submitter
- p.Leu169= Single submitter
- p.Leu514= Single submitter
Benign/Likely benign 3
- p.Asn910= Multiple submitters
- p.His159= Multiple submitters
- p.Pro179Ser Multiple submitters
Likely benign 21
- c.2881-8A>T Single submitter
- c.679-5G>A Single submitter
- p.Ala1000= Single submitter
- p.Ala36Thr Single submitter
- p.Ala576= Single submitter
- p.Ala746= Single submitter
- p.Arg701Gln Single submitter
- p.Arg725Cys Single submitter ⚠
- p.Arg904Gln Single submitter
- p.Asn833= Single submitter
- p.Asp115Glu Single submitter
- p.Asp995= Single submitter
- p.Glu750Lys Single submitter ⚠
- p.Gly1025Ser Single submitter
- p.Gly118= Single submitter
- p.His678= Single submitter
- p.His807Gln Single submitter
- p.Leu673= Single submitter
- p.Pro116= Single submitter
- p.Pro61= Single submitter
- p.Thr883= Single submitter
Uncertain significance 135
- p.Arg12His Multiple submitters ⚠
- p.Ala158Pro Single submitter ⚠
- p.Ala158Val Single submitter ⚠
- p.Ala166Val Single submitter ⚠
- p.Ala265Val Single submitter ⚠
- p.Ala327Val Single submitter ⚠
- p.Ala33Val Single submitter ⚠
- p.Ala348Thr Single submitter ⚠
- p.Ala468Thr Single submitter ⚠
- p.Ala500Ser Single submitter ⚠
- p.Ala539Thr Single submitter ⚠
- p.Ala540Thr Single submitter ⚠
- p.Ala570Thr Single submitter ⚠
- p.Ala60Val Single submitter ⚠
- p.Ala651Thr Single submitter ⚠
- p.Ala684Val Single submitter ⚠
- p.Ala746Val Single submitter ⚠
- p.Ala799Thr Single submitter ⚠
- p.Ala919Pro Single submitter ⚠
- p.Ala980Val Single submitter ⚠
- p.Arg128Gly Single submitter ⚠
- p.Arg128Ser Single submitter ⚠
- p.Arg375Gln Single submitter ⚠
- p.Arg425Gln Single submitter ⚠
- p.Arg448His Single submitter ⚠
- p.Arg544Gln Single submitter ⚠
- p.Arg544Trp Single submitter ⚠
- p.Arg564Gln Single submitter ⚠
- p.Arg582His Single submitter ⚠
- p.Arg715Gln Single submitter ⚠
- p.Arg725His Single submitter ⚠
- p.Arg768Gln Single submitter ⚠
- p.Arg771Gln Single submitter ⚠
- p.Arg784Trp Single submitter ⚠
- p.Arg84Gln Single submitter ⚠
- p.Arg875Trp Single submitter ⚠
- p.Arg876Cys Single submitter ⚠
- p.Arg921Cys Single submitter ⚠
- p.Arg921His Single submitter ⚠
- p.Arg928Thr Single submitter ⚠
- p.Arg932Cys Single submitter ⚠
- p.Arg940Gln Single submitter ⚠
- p.Arg977Trp Single submitter ⚠
- p.Arg985Gln Single submitter ⚠
- p.Asn193Tyr Single submitter ⚠
- p.Asn205Lys Single submitter ⚠
- p.Asn205Ser Single submitter ⚠
- p.Asn612Thr Single submitter ⚠
- p.Asn920Ser Single submitter ⚠
- p.Asp1044Asn Single submitter ⚠
- p.Asp1044Val Single submitter ⚠
- p.Asp565Asn Single submitter ⚠
- p.Asp727Asn Single submitter ⚠
- p.Asp739Tyr Single submitter ⚠
- p.Asp890Glu Single submitter ⚠
- p.Asp929Glu Single submitter ⚠
- p.Asp976Asn Single submitter ⚠
- p.Asp995Glu Single submitter ⚠
- p.Gln557Arg Single submitter ⚠
- p.Gln724Pro Single submitter ⚠
- p.Gln770Arg Single submitter ⚠
- p.Gln804His Single submitter ⚠
- p.Glu189Gln Single submitter ⚠
- p.Glu240Lys Single submitter ⚠
- p.Glu559Lys Single submitter ⚠
- p.Glu687Lys Single submitter ⚠
- p.Glu729Lys Single submitter ⚠
- p.Glu760Gln Single submitter ⚠
- p.Glu760Lys Single submitter ⚠
- p.Glu767Gln Single submitter ⚠
- p.Glu785Lys Single submitter ⚠
- p.Glu857Asp Single submitter ⚠
- p.Glu857Gln Single submitter ⚠
- p.Glu963Gln Single submitter ⚠
- p.Gly1032Ser Single submitter ⚠
- p.Gly14Arg Single submitter ⚠
- p.Gly155Arg Single submitter ⚠
- p.Gly26Arg Single submitter ⚠
- p.Gly289Ser Single submitter ⚠
- p.Gly647Ser Single submitter ⚠
- p.Gly6Ser Single submitter ⚠
- p.Gly744Asp Single submitter ⚠
- p.His671Tyr Single submitter ⚠
- p.His714Gln Single submitter ⚠
- p.Ile138Leu Single submitter ⚠
- p.Ile646Met Single submitter ⚠
- p.Ile646Ser Single submitter ⚠
- p.Ile656Met Single submitter ⚠
- p.Ile819Phe Single submitter ⚠
- p.Leu545Val Single submitter ⚠
- p.Leu696Met Single submitter ⚠
- p.Leu800Pro Single submitter ⚠
- p.Leu974del Single submitter
- p.Lys217Arg Single submitter ⚠
- p.Lys400Asn Single submitter ⚠
- p.Lys580Gln Single submitter ⚠
- p.Lys657Arg Single submitter ⚠
- p.Lys657Met Single submitter ⚠
- p.Lys936Arg Single submitter ⚠
- p.Met848Leu Single submitter ⚠
- p.Pro149Thr Single submitter ⚠
- p.Pro178Arg Single submitter ⚠
- p.Pro186Ser Single submitter ⚠
- p.Pro19Ser Single submitter ⚠
- p.Pro534Leu Single submitter ⚠
- p.Pro55Ser Single submitter ⚠
- p.Pro61Arg Single submitter ⚠
- p.Pro61Ser Single submitter ⚠
- p.Pro926Leu Single submitter ⚠
- p.Pro981Ser Single submitter ⚠
- p.Ser160Cys Single submitter ⚠
- p.Ser182Thr Single submitter ⚠
- p.Ser31Leu Single submitter ⚠
- p.Ser42Phe Single submitter ⚠
- p.Ser553Thr Single submitter ⚠
- p.Ser560Arg Single submitter ⚠
- p.Ser619Leu Single submitter ⚠
- p.Ser627fs Single submitter
- p.Ser931Asn Single submitter ⚠
- p.Ser979Leu Single submitter ⚠
- p.Thr175Met Single submitter ⚠
- p.Thr177Met Single submitter ⚠
- p.Thr497Ile Single submitter ⚠
- p.Thr603Ala Single submitter ⚠
- p.Thr806Ala Single submitter ⚠
- p.Tyr574Cys Single submitter ⚠
- p.Val161Met Single submitter ⚠
- p.Val191Ile Single submitter ⚠
- p.Val234Met Single submitter ⚠
- p.Val238Met Single submitter ⚠
- p.Val308Gly Single submitter ⚠
- p.Val323Ile Single submitter ⚠
- p.Val679Met Single submitter ⚠
- p.Val71Leu Single submitter ⚠
- p.Val780Ile Single submitter ⚠