CLIP3 — 67 ClinVar variants
All ClinVar germline CLIP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
3 Likely benign · 64 Uncertain significance
Full CLIP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLIP3 p.Ala251Val Uncertain significance Single submitter
- CLIP3 p.Ala271Thr Uncertain significance Single submitter
- CLIP3 p.Ala30Ser Uncertain significance Single submitter
- CLIP3 p.Ala7Thr Uncertain significance Single submitter
- CLIP3 p.Arg178His Uncertain significance Single submitter
- CLIP3 p.Arg229Gln Uncertain significance Single submitter
- CLIP3 p.Arg295His Uncertain significance Single submitter
- CLIP3 p.Arg384Cys Uncertain significance Single submitter
- CLIP3 p.Arg384His Uncertain significance Single submitter
- CLIP3 p.Arg411His Uncertain significance Single submitter
- CLIP3 p.Arg511Cys Uncertain significance Single submitter
- CLIP3 p.Arg511His Uncertain significance Single submitter
- CLIP3 p.Gln351Arg Uncertain significance Single submitter
- CLIP3 p.Gln93His Uncertain significance Single submitter
- CLIP3 p.Glu29Lys Uncertain significance Single submitter
- CLIP3 p.Gly387Ser Uncertain significance Single submitter
- CLIP3 p.Gly389Ala Uncertain significance Single submitter
- CLIP3 p.Gly389Asp Uncertain significance Single submitter
- CLIP3 p.Gly413Arg Uncertain significance Single submitter
- CLIP3 p.Gly436Arg Uncertain significance Single submitter
- CLIP3 p.Gly487Arg Uncertain significance Single submitter
- CLIP3 p.Gly493Arg Uncertain significance Single submitter
- CLIP3 p.His502Tyr Uncertain significance Single submitter
- CLIP3 p.Ile448Thr Uncertain significance Single submitter
- CLIP3 p.Leu292Met Uncertain significance Single submitter
- CLIP3 p.Lys274Arg Uncertain significance Single submitter
- CLIP3 p.Lys53Glu Uncertain significance Single submitter
- CLIP3 p.Met288Leu Uncertain significance Single submitter
- CLIP3 p.Pro13Ser Uncertain significance Single submitter
- CLIP3 p.Pro186Gln Uncertain significance Single submitter
- CLIP3 p.Pro368Ala Uncertain significance Single submitter
- CLIP3 p.Pro442Gln Uncertain significance Single submitter
- CLIP3 p.Ser32Arg Uncertain significance Single submitter
- CLIP3 p.Tyr55Cys Uncertain significance Single submitter
- CLIP3 p.Val140Ala Uncertain significance Single submitter
- CLIP3 p.Val266Met Uncertain significance Single submitter
- CLIP3 p.Val283Ile Uncertain significance Single submitter
- CLIP3 p.Val300Met Uncertain significance Single submitter
- CLIP3 p.Val496Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CLIP3 p.Ala137Val Uncertain significance Single submitter
- CLIP3 p.Ala148Val Uncertain significance Single submitter
- CLIP3 p.Ala214Thr Uncertain significance Single submitter
- CLIP3 p.Ala225Val Uncertain significance Single submitter
- CLIP3 p.Arg105His Uncertain significance Single submitter
- CLIP3 p.Arg259Gln Uncertain significance Single submitter
- CLIP3 p.Arg259Trp Uncertain significance Single submitter
- CLIP3 p.Arg299His Uncertain significance Single submitter
- CLIP3 p.Arg38Trp Uncertain significance Single submitter
- CLIP3 p.Arg433His Uncertain significance Single submitter
- CLIP3 p.Arg472Thr Uncertain significance Single submitter
- CLIP3 p.Asn63His Uncertain significance Single submitter
- CLIP3 p.Asp118Glu Uncertain significance Single submitter
- CLIP3 p.Asp381Glu Uncertain significance Single submitter
- CLIP3 p.Gly463Ser Uncertain significance Single submitter
- CLIP3 p.Ile485Thr Uncertain significance Single submitter
- CLIP3 p.Leu149Met Uncertain significance Single submitter
- CLIP3 p.Met244Val Uncertain significance Single submitter
- CLIP3 p.Pro65Leu Uncertain significance Single submitter
- CLIP3 p.Ser370Phe Uncertain significance Single submitter
- CLIP3 p.Ser402Phe Uncertain significance Single submitter
- CLIP3 p.Thr260Met Uncertain significance Single submitter
- CLIP3 p.Thr399Asn Uncertain significance Single submitter
- CLIP3 p.Val189Met Uncertain significance Single submitter
- CLIP3 p.Val27Ile Uncertain significance Single submitter
All CLIP3 variants
Likely benign 3
- p.Arg484= Single submitter
- p.Asp24Glu Single submitter
- p.Ser495= Single submitter
Uncertain significance 64
- p.Ala137Val Single submitter ⚠
- p.Ala148Val Single submitter ⚠
- p.Ala214Thr Single submitter ⚠
- p.Ala225Val Single submitter ⚠
- p.Ala251Val Single submitter ⚠
- p.Ala271Thr Single submitter ⚠
- p.Ala30Ser Single submitter ⚠
- p.Ala7Thr Single submitter ⚠
- p.Arg105His Single submitter ⚠
- p.Arg178His Single submitter ⚠
- p.Arg229Gln Single submitter ⚠
- p.Arg259Gln Single submitter ⚠
- p.Arg259Trp Single submitter ⚠
- p.Arg295His Single submitter ⚠
- p.Arg299His Single submitter ⚠
- p.Arg384Cys Single submitter ⚠
- p.Arg384His Single submitter ⚠
- p.Arg38Trp Single submitter ⚠
- p.Arg411His Single submitter ⚠
- p.Arg433His Single submitter ⚠
- p.Arg472Thr Single submitter ⚠
- p.Arg511Cys Single submitter ⚠
- p.Arg511His Single submitter ⚠
- p.Asn63His Single submitter ⚠
- p.Asp118Glu Single submitter ⚠
- p.Asp381Glu Single submitter ⚠
- p.Gln351Arg Single submitter ⚠
- p.Gln93His Single submitter ⚠
- p.Glu29Lys Single submitter ⚠
- p.Gly387Ser Single submitter ⚠
- p.Gly389Ala Single submitter ⚠
- p.Gly389Asp Single submitter ⚠
- p.Gly413Arg Single submitter ⚠
- p.Gly436Arg Single submitter ⚠
- p.Gly463Ser Single submitter ⚠
- p.Gly487Arg Single submitter ⚠
- p.Gly493Arg Single submitter ⚠
- p.His502Tyr Single submitter ⚠
- p.Ile448Thr Single submitter ⚠
- p.Ile485Thr Single submitter ⚠
- p.Leu149Met Single submitter ⚠
- p.Leu292Met Single submitter ⚠
- p.Lys274Arg Single submitter ⚠
- p.Lys53Glu Single submitter ⚠
- p.Met244Val Single submitter ⚠
- p.Met288Leu Single submitter ⚠
- p.Pro13Ser Single submitter ⚠
- p.Pro186Gln Single submitter ⚠
- p.Pro368Ala Single submitter ⚠
- p.Pro442Gln Single submitter ⚠
- p.Pro65Leu Single submitter ⚠
- p.Ser32Arg Single submitter ⚠
- p.Ser370Phe Single submitter ⚠
- p.Ser402Phe Single submitter ⚠
- p.Thr260Met Single submitter ⚠
- p.Thr399Asn Single submitter ⚠
- p.Tyr55Cys Single submitter ⚠
- p.Val140Ala Single submitter ⚠
- p.Val189Met Single submitter ⚠
- p.Val266Met Single submitter ⚠
- p.Val27Ile Single submitter ⚠
- p.Val283Ile Single submitter ⚠
- p.Val300Met Single submitter ⚠
- p.Val496Ile Single submitter ⚠