CLIP4 — 86 ClinVar variants
All ClinVar germline CLIP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
1 Benign · 85 Uncertain significance
Full CLIP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLIP4 p.Ala190Pro Uncertain significance Single submitter
- CLIP4 p.Ala240Thr Uncertain significance Single submitter
- CLIP4 p.Ala241Thr Uncertain significance Single submitter
- CLIP4 p.Ala337Thr Uncertain significance Single submitter
- CLIP4 p.Ala368Thr Uncertain significance Single submitter
- CLIP4 p.Ala476Thr Uncertain significance Single submitter
- CLIP4 p.Arg167Lys Uncertain significance Single submitter
- CLIP4 p.Arg19Lys Uncertain significance Single submitter
- CLIP4 p.Arg577Lys Uncertain significance Single submitter
- CLIP4 p.Arg606His Uncertain significance Single submitter
- CLIP4 p.Arg641Thr Uncertain significance Single submitter
- CLIP4 p.Arg686Gln Uncertain significance Single submitter
- CLIP4 p.Arg693Gln Uncertain significance Single submitter
- CLIP4 p.Arg693Trp Uncertain significance Single submitter
- CLIP4 p.Arg75Thr Uncertain significance Single submitter
- CLIP4 p.Asn14Asp Uncertain significance Single submitter
- CLIP4 p.Asn358Thr Uncertain significance Single submitter
- CLIP4 p.Asn704Ser Uncertain significance Single submitter
- CLIP4 p.Asp270Glu Uncertain significance Single submitter
- CLIP4 p.Cys336Phe Uncertain significance Single submitter
- CLIP4 p.Cys44Tyr Uncertain significance Single submitter
- CLIP4 p.Cys56Arg Uncertain significance Single submitter
- CLIP4 p.Gly123Asp Uncertain significance Single submitter
- CLIP4 p.Gly139Glu Uncertain significance Single submitter
- CLIP4 p.Gly532Asp Uncertain significance Single submitter
- CLIP4 p.His192Arg Uncertain significance Single submitter
- CLIP4 p.His361Arg Uncertain significance Single submitter
- CLIP4 p.Ile315Phe Uncertain significance Single submitter
- CLIP4 p.Ile73Val Uncertain significance Single submitter
- CLIP4 p.Ile85Ser Uncertain significance Single submitter
- CLIP4 p.Ile85Thr Uncertain significance Single submitter
- CLIP4 p.Ile87Val Uncertain significance Single submitter
- CLIP4 p.Ile88Thr Uncertain significance Single submitter
- CLIP4 p.Leu207Trp Uncertain significance Single submitter
- CLIP4 p.Leu422Pro Uncertain significance Single submitter
- CLIP4 p.Lys176Glu Uncertain significance Single submitter
- CLIP4 p.Lys339Asn Uncertain significance Single submitter
- CLIP4 p.Lys451Gln Uncertain significance Single submitter
- CLIP4 p.Met108Val Uncertain significance Single submitter
- CLIP4 p.Met233Ile Uncertain significance Single submitter
- CLIP4 p.Met233Thr Uncertain significance Single submitter
- CLIP4 p.Met454Thr Uncertain significance Single submitter
- CLIP4 p.Phe648Ile Uncertain significance Single submitter
- CLIP4 p.Pro163Leu Uncertain significance Single submitter
- CLIP4 p.Pro345Ser Uncertain significance Single submitter
- CLIP4 p.Pro39Leu Uncertain significance Single submitter
- CLIP4 p.Pro687Gln Uncertain significance Single submitter
- CLIP4 p.Ser173Leu Uncertain significance Single submitter
- CLIP4 p.Ser350Arg Uncertain significance Single submitter
- CLIP4 p.Ser404Leu Uncertain significance Single submitter
- CLIP4 p.Thr109Ala Uncertain significance Single submitter
- CLIP4 p.Thr133Ala Uncertain significance Single submitter
- CLIP4 p.Thr473Ala Uncertain significance Single submitter
- CLIP4 p.Trp514Cys Uncertain significance Single submitter
- CLIP4 p.Trp608Gly Uncertain significance Single submitter
- CLIP4 p.Tyr20His Uncertain significance Single submitter
- CLIP4 p.Val31Ile Uncertain significance Single submitter
- CLIP4 p.Val331Ile Uncertain significance Single submitter
- CLIP4 p.Val621Leu Uncertain significance Single submitter
- CLIP4 p.Val621Met Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CLIP4 p.Ala119Thr Uncertain significance Single submitter
- CLIP4 p.Arg145Gln Uncertain significance Single submitter
- CLIP4 p.Arg167Gly Uncertain significance Single submitter
- CLIP4 p.Arg606Cys Uncertain significance Single submitter
- CLIP4 p.Asn100Ser Uncertain significance Single submitter
- CLIP4 p.Asn635Ser Uncertain significance Single submitter
- CLIP4 p.Cys205Trp Uncertain significance Single submitter
- CLIP4 p.Cys481Trp Uncertain significance Single submitter
- CLIP4 p.Gln249His Uncertain significance Single submitter
- CLIP4 p.Glu246Asp Uncertain significance Single submitter
- CLIP4 p.Gly293Arg Uncertain significance Single submitter
- CLIP4 p.Gly293Glu Uncertain significance Single submitter
- CLIP4 p.Lys443Glu Uncertain significance Single submitter
- CLIP4 p.Lys94Asn Uncertain significance Single submitter
- CLIP4 p.Lys94Glu Uncertain significance Single submitter
- CLIP4 p.Pro175Leu Uncertain significance Single submitter
- CLIP4 p.Ser183Gly Uncertain significance Single submitter
- CLIP4 p.Ser374Phe Uncertain significance Single submitter
- CLIP4 p.Ser461Leu Uncertain significance Single submitter
- CLIP4 p.Ser586Phe Uncertain significance Single submitter
- CLIP4 p.Thr279Met Uncertain significance Single submitter
- CLIP4 p.Thr298Ile Uncertain significance Single submitter
- CLIP4 p.Thr383Met Uncertain significance Single submitter
- CLIP4 p.Tyr542Cys Uncertain significance Single submitter
- CLIP4 p.Val643Met Uncertain significance Single submitter
All CLIP4 variants
Benign 1
- p.Thr555= Multiple submitters
Uncertain significance 85
- p.Ala119Thr Single submitter ⚠
- p.Ala190Pro Single submitter ⚠
- p.Ala240Thr Single submitter ⚠
- p.Ala241Thr Single submitter ⚠
- p.Ala337Thr Single submitter ⚠
- p.Ala368Thr Single submitter ⚠
- p.Ala476Thr Single submitter ⚠
- p.Arg145Gln Single submitter ⚠
- p.Arg167Gly Single submitter ⚠
- p.Arg167Lys Single submitter ⚠
- p.Arg19Lys Single submitter ⚠
- p.Arg577Lys Single submitter ⚠
- p.Arg606Cys Single submitter ⚠
- p.Arg606His Single submitter ⚠
- p.Arg641Thr Single submitter ⚠
- p.Arg686Gln Single submitter ⚠
- p.Arg693Gln Single submitter ⚠
- p.Arg693Trp Single submitter ⚠
- p.Arg75Thr Single submitter ⚠
- p.Asn100Ser Single submitter ⚠
- p.Asn14Asp Single submitter ⚠
- p.Asn358Thr Single submitter ⚠
- p.Asn635Ser Single submitter ⚠
- p.Asn704Ser Single submitter ⚠
- p.Asp270Glu Single submitter ⚠
- p.Cys205Trp Single submitter ⚠
- p.Cys336Phe Single submitter ⚠
- p.Cys44Tyr Single submitter ⚠
- p.Cys481Trp Single submitter ⚠
- p.Cys56Arg Single submitter ⚠
- p.Gln249His Single submitter ⚠
- p.Glu246Asp Single submitter ⚠
- p.Gly123Asp Single submitter ⚠
- p.Gly139Glu Single submitter ⚠
- p.Gly293Arg Single submitter ⚠
- p.Gly293Glu Single submitter ⚠
- p.Gly532Asp Single submitter ⚠
- p.His192Arg Single submitter ⚠
- p.His361Arg Single submitter ⚠
- p.Ile315Phe Single submitter ⚠
- p.Ile73Val Single submitter ⚠
- p.Ile85Ser Single submitter ⚠
- p.Ile85Thr Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Ile88Thr Single submitter ⚠
- p.Leu207Trp Single submitter ⚠
- p.Leu422Pro Single submitter ⚠
- p.Lys176Glu Single submitter ⚠
- p.Lys339Asn Single submitter ⚠
- p.Lys443Glu Single submitter ⚠
- p.Lys451Gln Single submitter ⚠
- p.Lys94Asn Single submitter ⚠
- p.Lys94Glu Single submitter ⚠
- p.Met108Val Single submitter ⚠
- p.Met233Ile Single submitter ⚠
- p.Met233Thr Single submitter ⚠
- p.Met454Thr Single submitter ⚠
- p.Phe648Ile Single submitter ⚠
- p.Pro163Leu Single submitter ⚠
- p.Pro175Leu Single submitter ⚠
- p.Pro345Ser Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Pro687Gln Single submitter ⚠
- p.Ser173Leu Single submitter ⚠
- p.Ser183Gly Single submitter ⚠
- p.Ser350Arg Single submitter ⚠
- p.Ser374Phe Single submitter ⚠
- p.Ser404Leu Single submitter ⚠
- p.Ser461Leu Single submitter ⚠
- p.Ser586Phe Single submitter ⚠
- p.Thr109Ala Single submitter ⚠
- p.Thr133Ala Single submitter ⚠
- p.Thr279Met Single submitter ⚠
- p.Thr298Ile Single submitter ⚠
- p.Thr383Met Single submitter ⚠
- p.Thr473Ala Single submitter ⚠
- p.Trp514Cys Single submitter ⚠
- p.Trp608Gly Single submitter ⚠
- p.Tyr20His Single submitter ⚠
- p.Tyr542Cys Single submitter ⚠
- p.Val31Ile Single submitter ⚠
- p.Val331Ile Single submitter ⚠
- p.Val621Leu Single submitter ⚠
- p.Val621Met Single submitter ⚠
- p.Val643Met Single submitter ⚠