CLK1 — 70 ClinVar variants
All ClinVar germline CLK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
3 Likely benign · 67 Uncertain significance
Full CLK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLK1 p.Arg110Ser Uncertain significance Single submitter
- CLK1 p.Arg198Lys Uncertain significance Single submitter
- CLK1 p.Arg346Gly Uncertain significance Single submitter
- CLK1 p.Arg409His Uncertain significance Single submitter
- CLK1 p.Arg449His Uncertain significance Single submitter
- CLK1 p.Asn47Ser Uncertain significance Single submitter
- CLK1 p.Asp197Gly Uncertain significance Single submitter
- CLK1 p.Asp79Asn Uncertain significance Single submitter
- CLK1 p.Cys52Arg Uncertain significance Single submitter
- CLK1 p.Cys84Arg Uncertain significance Single submitter
- CLK1 p.Gln208Lys Uncertain significance Single submitter
- CLK1 p.Glu40Lys Uncertain significance Single submitter
- CLK1 p.His100Tyr Uncertain significance Single submitter
- CLK1 p.His336Pro Uncertain significance Single submitter
- CLK1 p.His474Pro Uncertain significance Single submitter
- CLK1 p.Ile119Met Uncertain significance Single submitter
- CLK1 p.Ile179Leu Uncertain significance Single submitter
- CLK1 p.Ile321Thr Uncertain significance Single submitter
- CLK1 p.Ile484Arg Uncertain significance Single submitter
- CLK1 p.Ile62Val Uncertain significance Single submitter
- CLK1 p.Ile73Val Uncertain significance Single submitter
- CLK1 p.Leu167Ile Uncertain significance Single submitter
- CLK1 p.Leu479Arg Uncertain significance Single submitter
- CLK1 p.Lys174Ile Uncertain significance Single submitter
- CLK1 p.Phe296Leu Uncertain significance Single submitter
- CLK1 p.Ser341Tyr Uncertain significance Single submitter
- CLK1 p.Ser69Arg Uncertain significance Single submitter
- CLK1 p.Thr216Ala Uncertain significance Single submitter
- CLK1 p.Thr338Ile Uncertain significance Single submitter
- CLK1 p.Thr7Ser Uncertain significance Single submitter
- CLK1 p.Tyr72Cys Uncertain significance Single submitter
- CLK1 p.Val164Ile Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CLK1 p.Arg126Cys Uncertain significance Single submitter
- CLK1 p.Arg127Cys Uncertain significance Single submitter
- CLK1 p.Arg204His Uncertain significance Single submitter
- CLK1 p.Arg311His Uncertain significance Single submitter
- CLK1 p.Arg314His Uncertain significance Single submitter
- CLK1 p.Arg409Cys Uncertain significance Single submitter
- CLK1 p.Arg416Leu Uncertain significance Single submitter
- CLK1 p.Arg449Cys Likely benign Single submitter
- CLK1 p.Arg6Lys Uncertain significance Single submitter
- CLK1 p.Arg89Cys Uncertain significance Single submitter
- CLK1 p.Asn282Ser Uncertain significance Single submitter
- CLK1 p.Asp333Glu Uncertain significance Single submitter
- CLK1 p.Asp444His Uncertain significance Single submitter
- CLK1 p.Glu142Gln Uncertain significance Single submitter
- CLK1 p.Glu334Lys Uncertain significance Single submitter
- CLK1 p.His120Gln Uncertain significance Single submitter
- CLK1 p.Ile239Leu Uncertain significance Single submitter
- CLK1 p.Ile368Val Uncertain significance Single submitter
- CLK1 p.Ile370Thr Uncertain significance Single submitter
- CLK1 p.Met440Ile Uncertain significance Single submitter
- CLK1 p.Pro307Ser Uncertain significance Single submitter
- CLK1 p.Pro319Leu Uncertain significance Single submitter
- CLK1 p.Ser122Cys Uncertain significance Single submitter
- CLK1 p.Ser122Gly Uncertain significance Single submitter
- CLK1 p.Ser24Asn Uncertain significance Single submitter
- CLK1 p.Thr315Asn Uncertain significance Single submitter
- CLK1 p.Val193Leu Uncertain significance Single submitter
- CLK1 p.Val196Met Uncertain significance Single submitter
All CLK1 variants
Likely benign 3
- p.Arg31Lys Single submitter
- p.Arg449Cys Single submitter ⚠
- p.Ser483Thr Single submitter
Uncertain significance 67
- c.-1+345C>T Single submitter
- c.-1+363C>G Single submitter
- c.-1+371T>C Single submitter
- c.-1+383C>G Single submitter
- c.-1+387G>A Single submitter
- c.-1+397G>C Single submitter
- c.-1+404G>A Single submitter
- c.-1+449G>A Single submitter
- p.Arg110Ser Single submitter ⚠
- p.Arg126Cys Single submitter ⚠
- p.Arg127Cys Single submitter ⚠
- p.Arg198Lys Single submitter ⚠
- p.Arg204His Single submitter ⚠
- p.Arg311His Single submitter ⚠
- p.Arg314His Single submitter ⚠
- p.Arg346Gly Single submitter ⚠
- p.Arg409Cys Single submitter ⚠
- p.Arg409His Single submitter ⚠
- p.Arg416Leu Single submitter ⚠
- p.Arg449His Single submitter ⚠
- p.Arg6Lys Single submitter ⚠
- p.Arg89Cys Single submitter ⚠
- p.Asn282Ser Single submitter ⚠
- p.Asn47Ser Single submitter ⚠
- p.Asp197Gly Single submitter ⚠
- p.Asp333Glu Single submitter ⚠
- p.Asp444His Single submitter ⚠
- p.Asp79Asn Single submitter ⚠
- p.Cys52Arg Single submitter ⚠
- p.Cys84Arg Single submitter ⚠
- p.Gln208Lys Single submitter ⚠
- p.Glu142Gln Single submitter ⚠
- p.Glu334Lys Single submitter ⚠
- p.Glu40Lys Single submitter ⚠
- p.His100Tyr Single submitter ⚠
- p.His120Gln Single submitter ⚠
- p.His336Pro Single submitter ⚠
- p.His474Pro Single submitter ⚠
- p.Ile119Met Single submitter ⚠
- p.Ile179Leu Single submitter ⚠
- p.Ile239Leu Single submitter ⚠
- p.Ile321Thr Single submitter ⚠
- p.Ile368Val Single submitter ⚠
- p.Ile370Thr Single submitter ⚠
- p.Ile484Arg Single submitter ⚠
- p.Ile62Val Single submitter ⚠
- p.Ile73Val Single submitter ⚠
- p.Leu167Ile Single submitter ⚠
- p.Leu479Arg Single submitter ⚠
- p.Lys174Ile Single submitter ⚠
- p.Met440Ile Single submitter ⚠
- p.Phe296Leu Single submitter ⚠
- p.Pro307Ser Single submitter ⚠
- p.Pro319Leu Single submitter ⚠
- p.Ser122Cys Single submitter ⚠
- p.Ser122Gly Single submitter ⚠
- p.Ser24Asn Single submitter ⚠
- p.Ser341Tyr Single submitter ⚠
- p.Ser69Arg Single submitter ⚠
- p.Thr216Ala Single submitter ⚠
- p.Thr315Asn Single submitter ⚠
- p.Thr338Ile Single submitter ⚠
- p.Thr7Ser Single submitter ⚠
- p.Tyr72Cys Single submitter ⚠
- p.Val164Ile Single submitter ⚠
- p.Val193Leu Single submitter ⚠
- p.Val196Met Single submitter ⚠