CLK2 — 82 ClinVar variants
All ClinVar germline CLK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
1 Benign · 3 Likely benign · 78 Uncertain significance
Full CLK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLK2 p.Ala140Pro Uncertain significance Single submitter
- CLK2 p.Ala188Val Uncertain significance Single submitter
- CLK2 p.Arg189Gln Uncertain significance Single submitter
- CLK2 p.Arg206Leu Uncertain significance Single submitter
- CLK2 p.Arg395Ser Uncertain significance Single submitter
- CLK2 p.Arg403Pro Uncertain significance Single submitter
- CLK2 p.Asn105Lys Uncertain significance Single submitter
- CLK2 p.Asp40His Uncertain significance Single submitter
- CLK2 p.Asp65Asn Uncertain significance Single submitter
- CLK2 p.Asp81Asn Uncertain significance Single submitter
- CLK2 p.Cys74Ser Uncertain significance Single submitter
- CLK2 p.Gly398Ala Uncertain significance Single submitter
- CLK2 p.Gly428Glu Uncertain significance Single submitter
- CLK2 p.His150Arg Uncertain significance Single submitter
- CLK2 p.His21Arg Uncertain significance Single submitter
- CLK2 p.His265Asn Uncertain significance Single submitter
- CLK2 p.Lys223Asn Uncertain significance Single submitter
- CLK2 p.Pro4Ser Uncertain significance Single submitter
- CLK2 p.Ser136Arg Uncertain significance Single submitter
- CLK2 p.Ser402Phe Uncertain significance Single submitter
- CLK2 p.Ser458Asn Uncertain significance Single submitter
- CLK2 p.Ser494Gly Uncertain significance Single submitter
- CLK2 p.Thr340Ile Uncertain significance Single submitter
- CLK2 p.Tyr108His Uncertain significance Single submitter
- CLK2 p.Tyr441Cys Uncertain significance Single submitter
Predictors split 54
The independent predictors disagree with each other — read with care.
- CLK2 p.Ala480Val Uncertain significance Single submitter
- CLK2 p.Arg103Gln Uncertain significance Single submitter
- CLK2 p.Arg109Cys Uncertain significance Single submitter
- CLK2 p.Arg112Cys Uncertain significance Single submitter
- CLK2 p.Arg115Gln Uncertain significance Single submitter
- CLK2 p.Arg120Gln Uncertain significance Single submitter
- CLK2 p.Arg121Gln Uncertain significance Single submitter
- CLK2 p.Arg121Trp Uncertain significance Single submitter
- CLK2 p.Arg124Cys Uncertain significance Single submitter
- CLK2 p.Arg126Trp Uncertain significance Single submitter
- CLK2 p.Arg15Trp Uncertain significance Single submitter
- CLK2 p.Arg185Gly Uncertain significance Single submitter
- CLK2 p.Arg206Gln Uncertain significance Single submitter
- CLK2 p.Arg23Gln Uncertain significance Single submitter
- CLK2 p.Arg23Trp Uncertain significance Single submitter
- CLK2 p.Arg25Gln Uncertain significance Single submitter
- CLK2 p.Arg268Cys Uncertain significance Single submitter
- CLK2 p.Arg29Pro Uncertain significance Single submitter
- CLK2 p.Arg30Gln Uncertain significance Single submitter
- CLK2 p.Arg403Gln Uncertain significance Single submitter
- CLK2 p.Arg406Gln Uncertain significance Single submitter
- CLK2 p.Arg418Cys Uncertain significance Single submitter
- CLK2 p.Arg418Leu Uncertain significance Single submitter
- CLK2 p.Arg41Gly Uncertain significance Single submitter
- CLK2 p.Arg41Trp Uncertain significance Single submitter
- CLK2 p.Arg429His Uncertain significance Single submitter
- CLK2 p.Arg432Cys Uncertain significance Single submitter
- CLK2 p.Arg432His Likely benign Single submitter
- CLK2 p.Arg440Trp Uncertain significance Single submitter
- CLK2 p.Arg44Trp Uncertain significance Single submitter
- CLK2 p.Arg46Trp Uncertain significance Single submitter
- CLK2 p.Arg483Gln Uncertain significance Single submitter
- CLK2 p.Arg483Gly Uncertain significance Single submitter
- CLK2 p.Arg483Trp Uncertain significance Single submitter
- CLK2 p.Arg495Trp Uncertain significance Single submitter
- CLK2 p.Arg54Cys Uncertain significance Single submitter
- CLK2 p.Arg5Gln Uncertain significance Single submitter
- CLK2 p.Arg71Gln Uncertain significance Single submitter
- CLK2 p.Arg79Cys Uncertain significance Single submitter
- CLK2 p.Arg86Gln Uncertain significance Single submitter
- CLK2 p.Asn210Ser Uncertain significance Single submitter
- CLK2 p.Asp422Asn Uncertain significance Single submitter
- CLK2 p.Glu217Gly Uncertain significance Single submitter
- CLK2 p.Glu304Gly Uncertain significance Single submitter
- CLK2 p.Glu448Gln Uncertain significance Single submitter
- CLK2 p.Glu461Gly Uncertain significance Single submitter
- CLK2 p.Gly417Ser Uncertain significance Single submitter
- CLK2 p.His269Asn Uncertain significance Single submitter
- CLK2 p.Leu309Ile Uncertain significance Single submitter
- CLK2 p.Lys279Glu Uncertain significance Single submitter
- CLK2 p.Ser37Asn Uncertain significance Single submitter
- CLK2 p.Ser37Gly Uncertain significance Single submitter
- CLK2 p.Tyr69Cys Uncertain significance Single submitter
- CLK2 p.Tyr82His Uncertain significance Single submitter
All CLK2 variants
Benign 1
- p.Val53= Single submitter
Likely benign 3
- p.Ala480Thr Single submitter
- p.Arg19His Single submitter
- p.Arg432His Single submitter ⚠
Uncertain significance 78
- p.Ala140Pro Single submitter ⚠
- p.Ala188Val Single submitter ⚠
- p.Ala480Val Single submitter ⚠
- p.Arg103Gln Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg112Cys Single submitter ⚠
- p.Arg115Gln Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg121Trp Single submitter ⚠
- p.Arg124Cys Single submitter ⚠
- p.Arg126Trp Single submitter ⚠
- p.Arg15Trp Single submitter ⚠
- p.Arg185Gly Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg206Leu Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Arg23Trp Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Arg268Cys Single submitter ⚠
- p.Arg29Pro Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg395Ser Single submitter ⚠
- p.Arg403Gln Single submitter ⚠
- p.Arg403Pro Single submitter ⚠
- p.Arg406Gln Single submitter ⚠
- p.Arg418Cys Single submitter ⚠
- p.Arg418Leu Single submitter ⚠
- p.Arg41Gly Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg429His Single submitter ⚠
- p.Arg432Cys Single submitter ⚠
- p.Arg440Trp Single submitter ⚠
- p.Arg44Trp Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg483Gln Single submitter ⚠
- p.Arg483Gly Single submitter ⚠
- p.Arg483Trp Single submitter ⚠
- p.Arg495Trp Single submitter ⚠
- p.Arg54Cys Single submitter ⚠
- p.Arg5Gln Single submitter ⚠
- p.Arg71Gln Single submitter ⚠
- p.Arg79Cys Single submitter ⚠
- p.Arg86Gln Single submitter ⚠
- p.Asn105Lys Single submitter ⚠
- p.Asn210Ser Single submitter ⚠
- p.Asp40His Single submitter ⚠
- p.Asp422Asn Single submitter ⚠
- p.Asp65Asn Single submitter ⚠
- p.Asp81Asn Single submitter ⚠
- p.Cys74Ser Single submitter ⚠
- p.Glu217Gly Single submitter ⚠
- p.Glu304Gly Single submitter ⚠
- p.Glu448Gln Single submitter ⚠
- p.Glu461Gly Single submitter ⚠
- p.Gly398Ala Single submitter ⚠
- p.Gly417Ser Single submitter ⚠
- p.Gly428Glu Single submitter ⚠
- p.His150Arg Single submitter ⚠
- p.His21Arg Single submitter ⚠
- p.His265Asn Single submitter ⚠
- p.His269Asn Single submitter ⚠
- p.Leu309Ile Single submitter ⚠
- p.Lys223Asn Single submitter ⚠
- p.Lys279Glu Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Ser136Arg Single submitter ⚠
- p.Ser37Asn Single submitter ⚠
- p.Ser37Gly Single submitter ⚠
- p.Ser402Phe Single submitter ⚠
- p.Ser458Asn Single submitter ⚠
- p.Ser494Gly Single submitter ⚠
- p.Thr340Ile Single submitter ⚠
- p.Tyr108His Single submitter ⚠
- p.Tyr441Cys Single submitter ⚠
- p.Tyr69Cys Single submitter ⚠
- p.Tyr82His Single submitter ⚠