CLK4 — 48 ClinVar variants
All ClinVar germline CLK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
1 Benign · 1 Likely benign · 46 Uncertain significance
Full CLK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLK4 p.Arg110Gly Uncertain significance Single submitter
- CLK4 p.Arg117His Uncertain significance Single submitter
- CLK4 p.Arg156Lys Uncertain significance Single submitter
- CLK4 p.Arg221Gln Uncertain significance Single submitter
- CLK4 p.Arg24His Uncertain significance Single submitter
- CLK4 p.Arg453Gln Uncertain significance Single submitter
- CLK4 p.Asn78Thr Uncertain significance Single submitter
- CLK4 p.Asp13Gly Uncertain significance Single submitter
- CLK4 p.Cys121Tyr Uncertain significance Single submitter
- CLK4 p.Cys222Arg Uncertain significance Single submitter
- CLK4 p.Cys236Ser Uncertain significance Single submitter
- CLK4 p.Cys54Trp Uncertain significance Single submitter
- CLK4 p.Gln402Glu Uncertain significance Single submitter
- CLK4 p.Glu252Lys Uncertain significance Single submitter
- CLK4 p.Gly166Ser Uncertain significance Single submitter
- CLK4 p.His278Tyr Uncertain significance Single submitter
- CLK4 p.His441Arg Uncertain significance Single submitter
- CLK4 p.His88Arg Uncertain significance Single submitter
- CLK4 p.Ile263Asn Uncertain significance Single submitter
- CLK4 p.Ile274Val Uncertain significance Single submitter
- CLK4 p.Leu337Ser Uncertain significance Single submitter
- CLK4 p.Lys481Glu Uncertain significance Single submitter
- CLK4 p.Met184Val Uncertain significance Single submitter
- CLK4 p.Ser335Arg Uncertain significance Single submitter
- CLK4 p.Thr328Met Uncertain significance Single submitter
- CLK4 p.Tyr67His Uncertain significance Single submitter
- CLK4 p.Tyr80Cys Uncertain significance Single submitter
- CLK4 p.Val191Ile Uncertain significance Single submitter
- CLK4 p.Val321Ala Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CLK4 p.Ala469Gly Uncertain significance Single submitter
- CLK4 p.Arg198Cys Uncertain significance Single submitter
- CLK4 p.Arg202Cys Uncertain significance Single submitter
- CLK4 p.Arg29Pro Uncertain significance Single submitter
- CLK4 p.Arg29Trp Uncertain significance Single submitter
- CLK4 p.Arg2Gln Uncertain significance Single submitter
- CLK4 p.Arg430Cys Uncertain significance Single submitter
- CLK4 p.Arg65Gln Uncertain significance Single submitter
- CLK4 p.Arg68Gln Uncertain significance Single submitter
- CLK4 p.Arg68Trp Uncertain significance Single submitter
- CLK4 p.Asp182Gly Uncertain significance Single submitter
- CLK4 p.Asp331Gly Uncertain significance Single submitter
- CLK4 p.Lys432Gln Uncertain significance Single submitter
- CLK4 p.Met400Leu Uncertain significance Single submitter
- CLK4 p.Phe437Cys Uncertain significance Single submitter
- CLK4 p.Ser123Asn Uncertain significance Single submitter
- CLK4 p.Val235Leu Uncertain significance Single submitter
All CLK4 variants
Benign 1
- p.Ile99= Single submitter
Likely benign 1
- p.Val73Ile Single submitter
Uncertain significance 46
- p.Ala469Gly Single submitter ⚠
- p.Arg110Gly Single submitter ⚠
- p.Arg117His Single submitter ⚠
- p.Arg156Lys Single submitter ⚠
- p.Arg198Cys Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg24His Single submitter ⚠
- p.Arg29Pro Single submitter ⚠
- p.Arg29Trp Single submitter ⚠
- p.Arg2Gln Single submitter ⚠
- p.Arg430Cys Single submitter ⚠
- p.Arg453Gln Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Arg68Trp Single submitter ⚠
- p.Asn78Thr Single submitter ⚠
- p.Asp13Gly Single submitter ⚠
- p.Asp182Gly Single submitter ⚠
- p.Asp331Gly Single submitter ⚠
- p.Cys121Tyr Single submitter ⚠
- p.Cys222Arg Single submitter ⚠
- p.Cys236Ser Single submitter ⚠
- p.Cys54Trp Single submitter ⚠
- p.Gln402Glu Single submitter ⚠
- p.Glu252Lys Single submitter ⚠
- p.Gly166Ser Single submitter ⚠
- p.His278Tyr Single submitter ⚠
- p.His441Arg Single submitter ⚠
- p.His88Arg Single submitter ⚠
- p.Ile263Asn Single submitter ⚠
- p.Ile274Val Single submitter ⚠
- p.Leu337Ser Single submitter ⚠
- p.Lys432Gln Single submitter ⚠
- p.Lys481Glu Single submitter ⚠
- p.Met184Val Single submitter ⚠
- p.Met400Leu Single submitter ⚠
- p.Phe437Cys Single submitter ⚠
- p.Ser123Asn Single submitter ⚠
- p.Ser335Arg Single submitter ⚠
- p.Thr328Met Single submitter ⚠
- p.Tyr67His Single submitter ⚠
- p.Tyr80Cys Single submitter ⚠
- p.Val191Ile Single submitter ⚠
- p.Val235Leu Single submitter ⚠
- p.Val321Ala Single submitter ⚠