CLNK — 84 ClinVar variants
All ClinVar germline CLNK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
2 Benign · 14 Likely benign · 68 Uncertain significance
Full CLNK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLNK p.Ala241Asp Uncertain significance Single submitter
- CLNK p.Arg184Lys Uncertain significance Single submitter
- CLNK p.Arg198Ser Uncertain significance Single submitter
- CLNK p.Arg257Thr Uncertain significance Single submitter
- CLNK p.Arg298Thr Uncertain significance Single submitter
- CLNK p.Arg32Gly Uncertain significance Single submitter
- CLNK p.Arg366Lys Uncertain significance Single submitter
- CLNK p.Arg52Lys Uncertain significance Single submitter
- CLNK p.Arg89Gln Uncertain significance Single submitter
- CLNK p.Asn354Lys Uncertain significance Single submitter
- CLNK p.Asn44Ser Uncertain significance Single submitter
- CLNK p.Asp113Gly Uncertain significance Single submitter
- CLNK p.Asp303Glu Uncertain significance Single submitter
- CLNK p.Asp379Glu Uncertain significance Single submitter
- CLNK p.Asp49Gly Uncertain significance Single submitter
- CLNK p.Asp71Glu Uncertain significance Single submitter
- CLNK p.Cys271Phe Uncertain significance Single submitter
- CLNK p.Cys337Phe Uncertain significance Single submitter
- CLNK p.Gln39Pro Uncertain significance Single submitter
- CLNK p.Glu179Lys Uncertain significance Single submitter
- CLNK p.Glu215Ala Uncertain significance Single submitter
- CLNK p.Glu281Lys Uncertain significance Single submitter
- CLNK p.Gly330Asp Uncertain significance Single submitter
- CLNK p.His100Asn Uncertain significance Single submitter
- CLNK p.His191Asn Uncertain significance Single submitter
- CLNK p.His391Tyr Uncertain significance Single submitter
- CLNK p.Ile33Phe Uncertain significance Single submitter
- CLNK p.Ile389Phe Uncertain significance Single submitter
- CLNK p.Lys11Glu Uncertain significance Single submitter
- CLNK p.Lys157Glu Uncertain significance Single submitter
- CLNK p.Phe54Leu Uncertain significance Single submitter
- CLNK p.Pro123Leu Uncertain significance Single submitter
- CLNK p.Pro137His Uncertain significance Single submitter
- CLNK p.Pro165Arg Uncertain significance Single submitter
- CLNK p.Pro265His Uncertain significance Single submitter
- CLNK p.Pro31Ser Uncertain significance Single submitter
- CLNK p.Pro345Ser Uncertain significance Single submitter
- CLNK p.Pro427Ser Uncertain significance Single submitter
- CLNK p.Ser250Gly Uncertain significance Single submitter
- CLNK p.Ser278Arg Uncertain significance Single submitter
- CLNK p.Thr108Ile Uncertain significance Single submitter
- CLNK p.Thr10Ile Uncertain significance Single submitter
- CLNK p.Thr116Ser Uncertain significance Single submitter
- CLNK p.Thr124Asn Uncertain significance Single submitter
- CLNK p.Thr422Pro Uncertain significance Single submitter
- CLNK p.Thr9Ser Uncertain significance Single submitter
- CLNK p.Val211Ala Uncertain significance Single submitter
- CLNK p.Val211Ile Uncertain significance Single submitter
- CLNK p.Val350Ala Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CLNK p.Arg362His Uncertain significance Single submitter
- CLNK p.Asn34Tyr Uncertain significance Single submitter
- CLNK p.Gln369His Uncertain significance Single submitter
- CLNK p.Glu344Gln Uncertain significance Single submitter
- CLNK p.Glu365Asp Uncertain significance Single submitter
- CLNK p.Glu380Lys Uncertain significance Single submitter
- CLNK p.Gly407Glu Uncertain significance Single submitter
- CLNK p.Gly5Cys Uncertain significance Single submitter
- CLNK p.Leu421His Uncertain significance Single submitter
- CLNK p.Lys405Asn Uncertain significance Single submitter
- CLNK p.Pro170Leu Uncertain significance Single submitter
- CLNK p.Pro175His Uncertain significance Single submitter
- CLNK p.Pro178Arg Uncertain significance Single submitter
- CLNK p.Pro180Leu Uncertain significance Single submitter
- CLNK p.Ser243Ile Uncertain significance Single submitter
- CLNK p.Ser299Phe Uncertain significance Single submitter
- CLNK p.Ser299Tyr Uncertain significance Single submitter
- CLNK p.Thr129Met Likely benign Single submitter
- CLNK p.Thr192Ile Uncertain significance Single submitter
- CLNK p.Thr248Met Likely benign Single submitter
- CLNK p.Val254Met Uncertain significance Single submitter
-
CLNK p.Arg362Cys
Likely benign
No assertion criteria
CLNK-related disorder
All CLNK variants
Benign 2
- p.Ile361= Multiple submitters
- p.Pro31Leu Multiple submitters
Likely benign 14
- p.Arg32His Single submitter
- p.Arg75Gln Single submitter
- p.Ile120Thr Single submitter
- p.Ile397= Single submitter
- p.Leu230Ser Single submitter
- p.Phe323Leu Single submitter
- p.Pro180= Single submitter
- p.Thr129Met Single submitter ⚠
- p.Thr248Met Single submitter ⚠
- p.Tyr352His Single submitter
- p.Val142Ile Single submitter
- p.Val153Ile Single submitter
- p.Arg362Cys No assertion criteria CLNK-related disorder ⚠
- p.Ile242Val No assertion criteria CLNK-related disorder
Uncertain significance 68
- p.Ala241Asp Single submitter ⚠
- p.Arg184Lys Single submitter ⚠
- p.Arg198Ser Single submitter ⚠
- p.Arg257Thr Single submitter ⚠
- p.Arg298Thr Single submitter ⚠
- p.Arg32Gly Single submitter ⚠
- p.Arg362His Single submitter ⚠
- p.Arg366Lys Single submitter ⚠
- p.Arg52Lys Single submitter ⚠
- p.Arg89Gln Single submitter ⚠
- p.Asn34Tyr Single submitter ⚠
- p.Asn354Lys Single submitter ⚠
- p.Asn44Ser Single submitter ⚠
- p.Asp113Gly Single submitter ⚠
- p.Asp303Glu Single submitter ⚠
- p.Asp379Glu Single submitter ⚠
- p.Asp49Gly Single submitter ⚠
- p.Asp71Glu Single submitter ⚠
- p.Cys271Phe Single submitter ⚠
- p.Cys337Phe Single submitter ⚠
- p.Gln369His Single submitter ⚠
- p.Gln39Pro Single submitter ⚠
- p.Glu179Lys Single submitter ⚠
- p.Glu215Ala Single submitter ⚠
- p.Glu281Lys Single submitter ⚠
- p.Glu344Gln Single submitter ⚠
- p.Glu365Asp Single submitter ⚠
- p.Glu380Lys Single submitter ⚠
- p.Gly330Asp Single submitter ⚠
- p.Gly407Glu Single submitter ⚠
- p.Gly5Cys Single submitter ⚠
- p.His100Asn Single submitter ⚠
- p.His191Asn Single submitter ⚠
- p.His391Tyr Single submitter ⚠
- p.Ile33Phe Single submitter ⚠
- p.Ile389Phe Single submitter ⚠
- p.Leu421His Single submitter ⚠
- p.Lys11Glu Single submitter ⚠
- p.Lys157Glu Single submitter ⚠
- p.Lys405Asn Single submitter ⚠
- p.Phe54Leu Single submitter ⚠
- p.Pro123Leu Single submitter ⚠
- p.Pro137His Single submitter ⚠
- p.Pro165Arg Single submitter ⚠
- p.Pro170Leu Single submitter ⚠
- p.Pro175His Single submitter ⚠
- p.Pro178Arg Single submitter ⚠
- p.Pro180Leu Single submitter ⚠
- p.Pro265His Single submitter ⚠
- p.Pro31Ser Single submitter ⚠
- p.Pro345Ser Single submitter ⚠
- p.Pro427Ser Single submitter ⚠
- p.Ser243Ile Single submitter ⚠
- p.Ser250Gly Single submitter ⚠
- p.Ser278Arg Single submitter ⚠
- p.Ser299Phe Single submitter ⚠
- p.Ser299Tyr Single submitter ⚠
- p.Thr108Ile Single submitter ⚠
- p.Thr10Ile Single submitter ⚠
- p.Thr116Ser Single submitter ⚠
- p.Thr124Asn Single submitter ⚠
- p.Thr192Ile Single submitter ⚠
- p.Thr422Pro Single submitter ⚠
- p.Thr9Ser Single submitter ⚠
- p.Val211Ala Single submitter ⚠
- p.Val211Ile Single submitter ⚠
- p.Val254Met Single submitter ⚠
- p.Val350Ala Single submitter ⚠