CLOCK — 84 ClinVar variants
All ClinVar germline CLOCK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
4 Benign · 6 Likely benign · 74 Uncertain significance
Full CLOCK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLOCK p.Ala432Pro Uncertain significance Single submitter
- CLOCK p.Ala691Gly Uncertain significance Single submitter
- CLOCK p.Arg242Lys Uncertain significance Single submitter
- CLOCK p.Arg435Pro Uncertain significance Single submitter
- CLOCK p.Arg543Gln Uncertain significance Single submitter
- CLOCK p.Arg699Lys Uncertain significance Single submitter
- CLOCK p.Arg831Gln Uncertain significance Single submitter
- CLOCK p.Asn410Thr Uncertain significance Single submitter
- CLOCK p.Asp119Ala Uncertain significance Single submitter
- CLOCK p.Asp128His Uncertain significance Single submitter
- CLOCK p.Asp69Asn Uncertain significance Single submitter
- CLOCK p.Asp839His Uncertain significance Single submitter
- CLOCK p.Gln465Arg Uncertain significance Single submitter
- CLOCK p.Gln488His Uncertain significance Single submitter
- CLOCK p.His354Arg Uncertain significance Single submitter
- CLOCK p.His525Gln Uncertain significance Single submitter
- CLOCK p.Ile169Val Uncertain significance Single submitter
- CLOCK p.Ile237Val Uncertain significance Single submitter
- CLOCK p.Ile607Phe Uncertain significance Single submitter
- CLOCK p.Ile607Ser Uncertain significance Single submitter
- CLOCK p.Ile78Thr Uncertain significance Single submitter
- CLOCK p.Leu142Phe Uncertain significance Single submitter
- CLOCK p.Leu180Val Uncertain significance Single submitter
- CLOCK p.Leu395Pro Uncertain significance Single submitter
- CLOCK p.Leu395Val Uncertain significance Single submitter
- CLOCK p.Leu730Arg Uncertain significance Single submitter
- CLOCK p.Leu800Phe Uncertain significance Single submitter
- CLOCK p.Lys45Asn Uncertain significance Single submitter
- CLOCK p.Lys76Asn Uncertain significance Single submitter
- CLOCK p.Met536Thr Uncertain significance Single submitter
- CLOCK p.Met536Val Uncertain significance Single submitter
- CLOCK p.Met611Val Uncertain significance Single submitter
- CLOCK p.Met729Thr Uncertain significance Single submitter
- CLOCK p.Met729Val Uncertain significance Single submitter
- CLOCK p.Met731Thr Uncertain significance Single submitter
- CLOCK p.Phe104Cys Uncertain significance Single submitter
- CLOCK p.Phe424Ser Uncertain significance Single submitter
- CLOCK p.Pro294Ser Uncertain significance Single submitter
- CLOCK p.Pro603Ser Uncertain significance Single submitter
- CLOCK p.Pro781Ser Uncertain significance Single submitter
- CLOCK p.Ser171Pro Uncertain significance Single submitter
- CLOCK p.Ser177Thr Uncertain significance Single submitter
- CLOCK p.Ser517Leu Uncertain significance Single submitter
- CLOCK p.Ser570Thr Uncertain significance Single submitter
- CLOCK p.Thr457Ala Uncertain significance Single submitter
- CLOCK p.Tyr245His Uncertain significance Single submitter
- CLOCK p.Val150Met Uncertain significance Single submitter
- CLOCK p.Val249Ala Uncertain significance Single submitter
- CLOCK p.Val710Met Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CLOCK p.Arg386Gln Uncertain significance Single submitter
- CLOCK p.Arg387Gln Uncertain significance Single submitter
- CLOCK p.Arg82Gln Uncertain significance Single submitter
- CLOCK p.Asn64Asp Uncertain significance Single submitter
- CLOCK p.Asp151His Uncertain significance Single submitter
- CLOCK p.Gln809Arg Uncertain significance Single submitter
- CLOCK p.Glu27Lys Uncertain significance Single submitter
- CLOCK p.Gly610Arg Uncertain significance Single submitter
- CLOCK p.Gly614Arg Uncertain significance Single submitter
- CLOCK p.Gly673Arg Uncertain significance Single submitter
- CLOCK p.Ile369Val Uncertain significance Single submitter
- CLOCK p.Ile541Leu Uncertain significance Single submitter
- CLOCK p.Leu118Val Uncertain significance Single submitter
- CLOCK p.Lys323Glu Uncertain significance Single submitter
- CLOCK p.Met266Leu Uncertain significance Single submitter
- CLOCK p.Phe122Tyr Uncertain significance Single submitter
- CLOCK p.Phe215Cys Uncertain significance Single submitter
- CLOCK p.Phe215Val Uncertain significance Single submitter
- CLOCK p.Phe695Leu Uncertain significance Single submitter
- CLOCK p.Ser416Gly Uncertain significance Single submitter
- CLOCK p.Ser440Pro Uncertain significance Single submitter
- CLOCK p.Ser489Tyr Uncertain significance Single submitter
- CLOCK p.Ser500Cys Uncertain significance Single submitter
- CLOCK p.Thr374Ser Uncertain significance Single submitter
- CLOCK p.Val714Met Uncertain significance Single submitter
All CLOCK variants
Benign 4
- c.674-10A>G Multiple submitters
- p.Ala34= Multiple submitters
- c.1206+10T>C Single submitter
- p.Phe233= Single submitter
Likely benign 6
- p.Gly235Glu Multiple submitters
- c.256+5A>T Single submitter
- p.Asp528= Single submitter
- p.Lys101= Single submitter
- p.Pro456Leu Single submitter
- p.Ser19Gly Single submitter
Uncertain significance 74
- p.Ala432Pro Single submitter ⚠
- p.Ala691Gly Single submitter ⚠
- p.Arg242Lys Single submitter ⚠
- p.Arg386Gln Single submitter ⚠
- p.Arg387Gln Single submitter ⚠
- p.Arg435Pro Single submitter ⚠
- p.Arg543Gln Single submitter ⚠
- p.Arg699Lys Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Arg831Gln Single submitter ⚠
- p.Asn410Thr Single submitter ⚠
- p.Asn64Asp Single submitter ⚠
- p.Asp119Ala Single submitter ⚠
- p.Asp128His Single submitter ⚠
- p.Asp151His Single submitter ⚠
- p.Asp69Asn Single submitter ⚠
- p.Asp839His Single submitter ⚠
- p.Gln465Arg Single submitter ⚠
- p.Gln488His Single submitter ⚠
- p.Gln809Arg Single submitter ⚠
- p.Glu27Lys Single submitter ⚠
- p.Gly610Arg Single submitter ⚠
- p.Gly614Arg Single submitter ⚠
- p.Gly673Arg Single submitter ⚠
- p.His354Arg Single submitter ⚠
- p.His525Gln Single submitter ⚠
- p.Ile169Val Single submitter ⚠
- p.Ile237Val Single submitter ⚠
- p.Ile369Val Single submitter ⚠
- p.Ile541Leu Single submitter ⚠
- p.Ile607Phe Single submitter ⚠
- p.Ile607Ser Single submitter ⚠
- p.Ile78Thr Single submitter ⚠
- p.Leu118Val Single submitter ⚠
- p.Leu142Phe Single submitter ⚠
- p.Leu180Val Single submitter ⚠
- p.Leu395Pro Single submitter ⚠
- p.Leu395Val Single submitter ⚠
- p.Leu730Arg Single submitter ⚠
- p.Leu800Phe Single submitter ⚠
- p.Lys323Glu Single submitter ⚠
- p.Lys45Asn Single submitter ⚠
- p.Lys76Asn Single submitter ⚠
- p.Met266Leu Single submitter ⚠
- p.Met536Thr Single submitter ⚠
- p.Met536Val Single submitter ⚠
- p.Met611Val Single submitter ⚠
- p.Met729Thr Single submitter ⚠
- p.Met729Val Single submitter ⚠
- p.Met731Thr Single submitter ⚠
- p.Phe104Cys Single submitter ⚠
- p.Phe122Tyr Single submitter ⚠
- p.Phe215Cys Single submitter ⚠
- p.Phe215Val Single submitter ⚠
- p.Phe424Ser Single submitter ⚠
- p.Phe695Leu Single submitter ⚠
- p.Pro294Ser Single submitter ⚠
- p.Pro603Ser Single submitter ⚠
- p.Pro781Ser Single submitter ⚠
- p.Ser171Pro Single submitter ⚠
- p.Ser177Thr Single submitter ⚠
- p.Ser416Gly Single submitter ⚠
- p.Ser440Pro Single submitter ⚠
- p.Ser489Tyr Single submitter ⚠
- p.Ser500Cys Single submitter ⚠
- p.Ser517Leu Single submitter ⚠
- p.Ser570Thr Single submitter ⚠
- p.Thr374Ser Single submitter ⚠
- p.Thr457Ala Single submitter ⚠
- p.Tyr245His Single submitter ⚠
- p.Val150Met Single submitter ⚠
- p.Val249Ala Single submitter ⚠
- p.Val710Met Single submitter ⚠
- p.Val714Met Single submitter ⚠