CLPSL1 — 25 ClinVar variants
All ClinVar germline CLPSL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
1 Likely benign · 24 Uncertain significance
Full CLPSL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLPSL1 p.Ala116Val Uncertain significance Single submitter
- CLPSL1 p.Ala53Thr Uncertain significance Single submitter
- CLPSL1 p.Ala82Val Uncertain significance Single submitter
- CLPSL1 p.Arg112Met Uncertain significance Single submitter
- CLPSL1 p.Gln113Pro Uncertain significance Single submitter
- CLPSL1 p.Gln5Pro Uncertain significance Single submitter
- CLPSL1 p.Gln72Arg Uncertain significance Single submitter
- CLPSL1 p.Glu97Gln Uncertain significance Single submitter
- CLPSL1 p.His60Gln Uncertain significance Single submitter
- CLPSL1 p.Leu17Ile Uncertain significance Single submitter
- CLPSL1 p.Pro54Ala Uncertain significance Single submitter
- CLPSL1 p.Ser101Thr Uncertain significance Single submitter
- CLPSL1 p.Thr73Lys Uncertain significance Single submitter
- CLPSL1 p.Val75Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CLPSL1 p.Arg106Cys Uncertain significance Single submitter
- CLPSL1 p.Arg41Pro Uncertain significance Single submitter
- CLPSL1 p.Arg87Trp Uncertain significance Single submitter
- CLPSL1 p.Cys45Ser Uncertain significance Single submitter
- CLPSL1 p.Cys50Arg Uncertain significance Single submitter
- CLPSL1 p.Cys61Gly Uncertain significance Single submitter
- CLPSL1 p.Glu37Gly Uncertain significance Single submitter
- CLPSL1 p.Gly23Asp Uncertain significance Single submitter
- CLPSL1 p.Gly78Asp Uncertain significance Single submitter
- CLPSL1 p.Leu10Pro Uncertain significance Single submitter
All CLPSL1 variants
Likely benign 1
- p.Glu34Asp Single submitter
Uncertain significance 24
- p.Ala116Val Single submitter ⚠
- p.Ala53Thr Single submitter ⚠
- p.Ala82Val Single submitter ⚠
- p.Arg106Cys Single submitter ⚠
- p.Arg112Met Single submitter ⚠
- p.Arg41Pro Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Cys45Ser Single submitter ⚠
- p.Cys50Arg Single submitter ⚠
- p.Cys61Gly Single submitter ⚠
- p.Gln113Pro Single submitter ⚠
- p.Gln5Pro Single submitter ⚠
- p.Gln72Arg Single submitter ⚠
- p.Glu37Gly Single submitter ⚠
- p.Glu97Gln Single submitter ⚠
- p.Gly23Asp Single submitter ⚠
- p.Gly78Asp Single submitter ⚠
- p.His60Gln Single submitter ⚠
- p.Leu10Pro Single submitter ⚠
- p.Leu17Ile Single submitter ⚠
- p.Pro54Ala Single submitter ⚠
- p.Ser101Thr Single submitter ⚠
- p.Thr73Lys Single submitter ⚠
- p.Val75Met Single submitter ⚠