CLPSL2 — 16 ClinVar variants
All ClinVar germline CLPSL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
16 Uncertain significance
Full CLPSL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLPSL2 p.Ala54Gly Uncertain significance Single submitter
- CLPSL2 p.Ala57Val Uncertain significance Single submitter
- CLPSL2 p.Arg81Trp Uncertain significance Single submitter
- CLPSL2 p.Asn75Ser Uncertain significance Single submitter
- CLPSL2 p.Gly10Ala Uncertain significance Single submitter
- CLPSL2 p.His36Tyr Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CLPSL2 p.Ala54Asp Uncertain significance Single submitter
- CLPSL2 p.Arg95Cys Uncertain significance Single submitter
- CLPSL2 p.Arg96Trp Uncertain significance Single submitter
- CLPSL2 p.Leu12Arg Uncertain significance Single submitter
- CLPSL2 p.Leu19Phe Uncertain significance Single submitter
- CLPSL2 p.Lys28Thr Uncertain significance Single submitter
- CLPSL2 p.Pro58Leu Uncertain significance Single submitter
- CLPSL2 p.Pro68Thr Uncertain significance Single submitter
- CLPSL2 p.Ser42Gly Uncertain significance Single submitter
- CLPSL2 p.Thr85Met Uncertain significance Single submitter
All CLPSL2 variants
Uncertain significance 16
- p.Ala54Asp Single submitter ⚠
- p.Ala54Gly Single submitter ⚠
- p.Ala57Val Single submitter ⚠
- p.Arg81Trp Single submitter ⚠
- p.Arg95Cys Single submitter ⚠
- p.Arg96Trp Single submitter ⚠
- p.Asn75Ser Single submitter ⚠
- p.Gly10Ala Single submitter ⚠
- p.His36Tyr Single submitter ⚠
- p.Leu12Arg Single submitter ⚠
- p.Leu19Phe Single submitter ⚠
- p.Lys28Thr Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Pro68Thr Single submitter ⚠
- p.Ser42Gly Single submitter ⚠
- p.Thr85Met Single submitter ⚠