CLRN3 — 42 ClinVar variants
All ClinVar germline CLRN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
6 Likely benign · 36 Uncertain significance
Full CLRN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLRN3 p.Ala149Ser Uncertain significance Single submitter
- CLRN3 p.Ala149Thr Uncertain significance Single submitter
- CLRN3 p.Ala149Val Uncertain significance Single submitter
- CLRN3 p.Gln207Arg Uncertain significance Single submitter
- CLRN3 p.Gln31Pro Uncertain significance Single submitter
- CLRN3 p.Glu158Lys Uncertain significance Single submitter
- CLRN3 p.Gly125Glu Uncertain significance Single submitter
- CLRN3 p.Gly134Glu Uncertain significance Single submitter
- CLRN3 p.Leu78Ser Uncertain significance Single submitter
- CLRN3 p.Lys5Asn Uncertain significance Single submitter
- CLRN3 p.Phe147Leu Uncertain significance Single submitter
- CLRN3 p.Ser104Pro Uncertain significance Single submitter
- CLRN3 p.Thr103Lys Uncertain significance Single submitter
- CLRN3 p.Thr131Ile Uncertain significance Single submitter
- CLRN3 p.Thr151Met Uncertain significance Single submitter
- CLRN3 p.Thr173Met Uncertain significance Single submitter
- CLRN3 p.Thr194Ile Uncertain significance Single submitter
- CLRN3 p.Thr88Ile Uncertain significance Single submitter
- CLRN3 p.Trp33Leu Uncertain significance Single submitter
- CLRN3 p.Val195Ile Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CLRN3 p.Ala149Glu Uncertain significance Single submitter
- CLRN3 p.Arg208Trp Uncertain significance Single submitter
- CLRN3 p.Asn46His Uncertain significance Single submitter
- CLRN3 p.Gly136Asp Uncertain significance Single submitter
- CLRN3 p.Gly136Val Uncertain significance Single submitter
- CLRN3 p.His90Arg Uncertain significance Single submitter
- CLRN3 p.Ile102Thr Uncertain significance Single submitter
- CLRN3 p.Ile116Met Uncertain significance Single submitter
- CLRN3 p.Leu106Gln Uncertain significance Single submitter
- CLRN3 p.Leu28Val Uncertain significance Single submitter
- CLRN3 p.Lys74Met Uncertain significance Single submitter
- CLRN3 p.Pro126Leu Uncertain significance Single submitter
- CLRN3 p.Thr127Met Likely benign Single submitter
- CLRN3 p.Thr196Asn Uncertain significance Single submitter
- CLRN3 p.Tyr113Asn Uncertain significance Single submitter
- CLRN3 p.Val129Leu Uncertain significance Single submitter
- CLRN3 p.Val140Phe Uncertain significance Single submitter
- CLRN3 p.Val187Ile Likely benign Single submitter
All CLRN3 variants
Likely benign 6
- p.Arg208Gln Single submitter
- p.Arg57His Single submitter
- p.Ser65Asn Single submitter
- p.Ser91Leu Single submitter
- p.Thr127Met Single submitter ⚠
- p.Val187Ile Single submitter ⚠
Uncertain significance 36
- p.Ala149Glu Single submitter ⚠
- p.Ala149Ser Single submitter ⚠
- p.Ala149Thr Single submitter ⚠
- p.Ala149Val Single submitter ⚠
- p.Arg208Trp Single submitter ⚠
- p.Asn46His Single submitter ⚠
- p.Gln207Arg Single submitter ⚠
- p.Gln31Pro Single submitter ⚠
- p.Glu158Lys Single submitter ⚠
- p.Gly125Glu Single submitter ⚠
- p.Gly134Glu Single submitter ⚠
- p.Gly136Asp Single submitter ⚠
- p.Gly136Val Single submitter ⚠
- p.His90Arg Single submitter ⚠
- p.Ile102Thr Single submitter ⚠
- p.Ile116Met Single submitter ⚠
- p.Leu106Gln Single submitter ⚠
- p.Leu28Val Single submitter ⚠
- p.Leu78Ser Single submitter ⚠
- p.Lys5Asn Single submitter ⚠
- p.Lys74Met Single submitter ⚠
- p.Phe147Leu Single submitter ⚠
- p.Pro126Leu Single submitter ⚠
- p.Ser104Pro Single submitter ⚠
- p.Thr103Lys Single submitter ⚠
- p.Thr131Ile Single submitter ⚠
- p.Thr151Met Single submitter ⚠
- p.Thr173Met Single submitter ⚠
- p.Thr194Ile Single submitter ⚠
- p.Thr196Asn Single submitter ⚠
- p.Thr88Ile Single submitter ⚠
- p.Trp33Leu Single submitter ⚠
- p.Tyr113Asn Single submitter ⚠
- p.Val129Leu Single submitter ⚠
- p.Val140Phe Single submitter ⚠
- p.Val195Ile Single submitter ⚠