CLSPN — 179 ClinVar variants
All ClinVar germline CLSPN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 170 flagged for review →
1 Benign · 8 Likely benign · 170 Uncertain significance
Full CLSPN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 170
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 128
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLSPN p.Ala1222Asp Uncertain significance Single submitter
- CLSPN p.Ala126Val Uncertain significance Single submitter
- CLSPN p.Ala1295Val Uncertain significance Single submitter
- CLSPN p.Ala379Val Uncertain significance Single submitter
- CLSPN p.Ala450Thr Uncertain significance Single submitter
- CLSPN p.Ala543Pro Uncertain significance Single submitter
- CLSPN p.Ala578Thr Uncertain significance Single submitter
- CLSPN p.Ala816Val Uncertain significance Single submitter
- CLSPN p.Ala822Val Uncertain significance Single submitter
- CLSPN p.Ala845Thr Uncertain significance Single submitter
- CLSPN p.Ala856Gly Uncertain significance Single submitter
- CLSPN p.Ala889Asp Uncertain significance Single submitter
- CLSPN p.Arg1243Thr Uncertain significance Single submitter
- CLSPN p.Arg1278Gln Uncertain significance Single submitter
- CLSPN p.Arg273Lys Uncertain significance Single submitter
- CLSPN p.Arg509Gln Uncertain significance Single submitter
- CLSPN p.Arg546Lys Uncertain significance Single submitter
- CLSPN p.Arg613Cys Uncertain significance Single submitter
- CLSPN p.Arg795Cys Uncertain significance Single submitter
- CLSPN p.Arg893Gln Uncertain significance Single submitter
- CLSPN p.Asn1257His Uncertain significance Single submitter
- CLSPN p.Asn242Ser Uncertain significance Single submitter
- CLSPN p.Asn378Ser Uncertain significance Single submitter
- CLSPN p.Asn552His Uncertain significance Single submitter
- CLSPN p.Asn749Lys Uncertain significance Single submitter
- CLSPN p.Asp1011Gly Uncertain significance Single submitter
- CLSPN p.Asp1032Val Uncertain significance Single submitter
- CLSPN p.Asp1033Glu Uncertain significance Single submitter
- CLSPN p.Asp1108Gly Uncertain significance Single submitter
- CLSPN p.Asp143Gly Uncertain significance Single submitter
- CLSPN p.Asp204Asn Uncertain significance Single submitter
- CLSPN p.Asp213Glu Uncertain significance Single submitter
- CLSPN p.Asp559Val Uncertain significance Single submitter
- CLSPN p.Asp71Gly Uncertain significance Single submitter
- CLSPN p.Asp722Gly Uncertain significance Single submitter
- CLSPN p.Cys397Phe Uncertain significance Single submitter
- CLSPN p.Cys862Tyr Uncertain significance Single submitter
- CLSPN p.Cys944Ser Uncertain significance Single submitter
- CLSPN p.Gln1205Arg Uncertain significance Single submitter
- CLSPN p.Gln1229His Uncertain significance Single submitter
- CLSPN p.Gln388His Uncertain significance Single submitter
- CLSPN p.Gln444His Uncertain significance Single submitter
- CLSPN p.Gln617Arg Uncertain significance Single submitter
- CLSPN p.Gln792Arg Uncertain significance Single submitter
- CLSPN p.Gln792Lys Uncertain significance Single submitter
- CLSPN p.Gln886Lys Uncertain significance Single submitter
- CLSPN p.Glu1180Lys Uncertain significance Single submitter
- CLSPN p.Glu466Lys Uncertain significance Single submitter
- CLSPN p.Glu769Val Uncertain significance Single submitter
- CLSPN p.Glu837Lys Uncertain significance Single submitter
- CLSPN p.Gly328Arg Uncertain significance Single submitter
- CLSPN p.Gly364Cys Uncertain significance Single submitter
- CLSPN p.Gly364Ser Uncertain significance Single submitter
- CLSPN p.Gly458Asp Uncertain significance Single submitter
- CLSPN p.Gly484Arg Uncertain significance Single submitter
- CLSPN p.Gly548Arg Uncertain significance Single submitter
- CLSPN p.Gly627Trp Uncertain significance Single submitter
- CLSPN p.Gly6Ser Uncertain significance Single submitter
- CLSPN p.Gly796Glu Uncertain significance Single submitter
- CLSPN p.Gly804Glu Uncertain significance Single submitter
- CLSPN p.His10Asn Uncertain significance Single submitter
- CLSPN p.His327Tyr Uncertain significance Single submitter
- CLSPN p.His343Tyr Uncertain significance Single submitter
- CLSPN p.His361Tyr Uncertain significance Single submitter
- CLSPN p.His926Gln Uncertain significance Single submitter
- CLSPN p.Ile1076Thr Uncertain significance Single submitter
- CLSPN p.Ile1143Thr Uncertain significance Single submitter
- CLSPN p.Ile1228Thr Uncertain significance Single submitter
- CLSPN p.Ile155Val Uncertain significance Single submitter
- CLSPN p.Ile347Val Uncertain significance Single submitter
- CLSPN p.Ile38Thr Uncertain significance Single submitter
- CLSPN p.Ile519Met Uncertain significance Single submitter
- CLSPN p.Ile687Val Uncertain significance Single submitter
- CLSPN p.Ile706Leu Uncertain significance Single submitter
- CLSPN p.Ile706Thr Uncertain significance Single submitter
- CLSPN p.Leu1024Val Uncertain significance Single submitter
- CLSPN p.Leu1235Pro Uncertain significance Single submitter
- CLSPN p.Leu1269Phe Uncertain significance Single submitter
- CLSPN p.Leu233Val Uncertain significance Single submitter
- CLSPN p.Leu456Val Uncertain significance Single submitter
- CLSPN p.Leu813Pro Uncertain significance Single submitter
- CLSPN p.Leu927Ile Uncertain significance Single submitter
- CLSPN p.Lys105Arg Uncertain significance Single submitter
- CLSPN p.Lys192Gln Uncertain significance Single submitter
- CLSPN p.Lys277Arg Uncertain significance Single submitter
- CLSPN p.Lys470Glu Uncertain significance Single submitter
- CLSPN p.Lys60Arg Uncertain significance Single submitter
- CLSPN p.Lys693Thr Uncertain significance Single submitter
- CLSPN p.Lys697Thr Uncertain significance Single submitter
- CLSPN p.Lys752Arg Uncertain significance Single submitter
- CLSPN p.Lys89Gln Uncertain significance Single submitter
- CLSPN p.Met1149Val Uncertain significance Single submitter
- CLSPN p.Met1186Val Uncertain significance Single submitter
- CLSPN p.Met1207Val Uncertain significance Single submitter
- CLSPN p.Met908Arg Uncertain significance Single submitter
- CLSPN p.Pro1089Leu Uncertain significance Single submitter
- CLSPN p.Pro1132Leu Uncertain significance Single submitter
- CLSPN p.Pro1225Ser Uncertain significance Single submitter
- CLSPN p.Pro1277Leu Uncertain significance Single submitter
- CLSPN p.Pro1317Ser Uncertain significance Single submitter
- CLSPN p.Pro226Thr Uncertain significance Single submitter
- CLSPN p.Pro27Ser Uncertain significance Single submitter
- CLSPN p.Pro453Ser Uncertain significance Single submitter
- CLSPN p.Pro522Ser Uncertain significance Single submitter
- CLSPN p.Pro716Thr Uncertain significance Single submitter
- CLSPN p.Pro832Leu Uncertain significance Single submitter
- CLSPN p.Ser268Leu Uncertain significance Single submitter
- CLSPN p.Ser30Thr Uncertain significance Single submitter
- CLSPN p.Ser337Thr Uncertain significance Single submitter
- CLSPN p.Ser764Pro Uncertain significance Single submitter
- CLSPN p.Ser823Phe Uncertain significance Single submitter
- CLSPN p.Ser931Thr Uncertain significance Single submitter
- CLSPN p.Thr142Ala Uncertain significance Single submitter
- CLSPN p.Thr387Ile Uncertain significance Single submitter
- CLSPN p.Thr391Ile Uncertain significance Single submitter
- CLSPN p.Thr562Asn Uncertain significance Single submitter
- CLSPN p.Thr79Pro Uncertain significance Single submitter
- CLSPN p.Thr916Ile Uncertain significance Single submitter
- CLSPN p.Thr987Ile Uncertain significance Single submitter
- CLSPN p.Tyr786Ser Uncertain significance Single submitter
- CLSPN p.Tyr843Cys Uncertain significance Single submitter
- CLSPN p.Val1083Ile Uncertain significance Single submitter
- CLSPN p.Val18Ile Uncertain significance Single submitter
- CLSPN p.Val382Ile Uncertain significance Single submitter
- CLSPN p.Val402Glu Uncertain significance Single submitter
- CLSPN p.Val573Ile Uncertain significance Single submitter
- CLSPN p.Val61Phe Uncertain significance Single submitter
-
CLSPN p.Glu1195Asp
Uncertain significance
No assertion criteria
myoepithelial tumor
Predictors split 42
The independent predictors disagree with each other — read with care.
- CLSPN p.Ala874Gly Uncertain significance Single submitter
- CLSPN p.Arg1112Gln Uncertain significance Single submitter
- CLSPN p.Arg1134Gln Uncertain significance Single submitter
- CLSPN p.Arg1173Lys Uncertain significance Single submitter
- CLSPN p.Arg323Trp Uncertain significance Single submitter
- CLSPN p.Arg534Cys Uncertain significance Single submitter
- CLSPN p.Arg534His Uncertain significance Single submitter
- CLSPN p.Arg59Ser Uncertain significance Single submitter
- CLSPN p.Arg616His Uncertain significance Single submitter
- CLSPN p.Arg807Ser Uncertain significance Single submitter
- CLSPN p.Asn942Lys Uncertain significance Single submitter
- CLSPN p.Asp1124Glu Uncertain significance Single submitter
- CLSPN p.Asp515Asn Uncertain significance Single submitter
- CLSPN p.Cys981Tyr Uncertain significance Single submitter
- CLSPN p.Glu1068Lys Uncertain significance Single submitter
- CLSPN p.Glu1070Lys Uncertain significance Single submitter
- CLSPN p.Glu648Gly Uncertain significance Single submitter
- CLSPN p.Glu651Lys Uncertain significance Single submitter
- CLSPN p.Glu669Lys Uncertain significance Single submitter
- CLSPN p.Glu672Lys Uncertain significance Single submitter
- CLSPN p.Glu85Lys Uncertain significance Single submitter
- CLSPN p.Glu90Gln Uncertain significance Single submitter
- CLSPN p.Glu994Lys Uncertain significance Single submitter
- CLSPN p.Leu863Ser Uncertain significance Single submitter
- CLSPN p.Leu911Met Uncertain significance Single submitter
- CLSPN p.Lys101Glu Uncertain significance Single submitter
- CLSPN p.Lys1305Asn Uncertain significance Single submitter
- CLSPN p.Lys250Asn Uncertain significance Single submitter
- CLSPN p.Lys589Glu Uncertain significance Single submitter
- CLSPN p.Lys99Glu Uncertain significance Single submitter
- CLSPN p.Met180Thr Uncertain significance Single submitter
- CLSPN p.Phe1239Cys Uncertain significance Single submitter
- CLSPN p.Phe1239Leu Uncertain significance Single submitter
- CLSPN p.Phe318Leu Uncertain significance Single submitter
- CLSPN p.Ser141Cys Uncertain significance Single submitter
- CLSPN p.Ser265Asn Uncertain significance Single submitter
- CLSPN p.Ser53Asn Uncertain significance Single submitter
- CLSPN p.Ser65Thr Uncertain significance Single submitter
- CLSPN p.Ser954Phe Uncertain significance Single submitter
- CLSPN p.Tyr306His Uncertain significance Single submitter
- CLSPN p.Val1060Glu Uncertain significance Single submitter
- CLSPN p.Val553Met Uncertain significance Single submitter
All CLSPN variants
Benign 1
- p.Lys338= Multiple submitters
Likely benign 8
- p.Arg1331Gln Single submitter
- p.Ile100Val Single submitter
- p.Leu302= Single submitter
- p.Lys55= Single submitter
- p.Met1226Val Single submitter
- p.Met560Val Single submitter
- p.Pro892Thr Single submitter
- p.Val555Ile Single submitter
Uncertain significance 170
- p.Ala1222Asp Single submitter ⚠
- p.Ala126Val Single submitter ⚠
- p.Ala1295Val Single submitter ⚠
- p.Ala379Val Single submitter ⚠
- p.Ala450Thr Single submitter ⚠
- p.Ala543Pro Single submitter ⚠
- p.Ala578Thr Single submitter ⚠
- p.Ala816Val Single submitter ⚠
- p.Ala822Val Single submitter ⚠
- p.Ala845Thr Single submitter ⚠
- p.Ala856Gly Single submitter ⚠
- p.Ala874Gly Single submitter ⚠
- p.Ala889Asp Single submitter ⚠
- p.Arg1112Gln Single submitter ⚠
- p.Arg1134Gln Single submitter ⚠
- p.Arg1173Lys Single submitter ⚠
- p.Arg1243Thr Single submitter ⚠
- p.Arg1278Gln Single submitter ⚠
- p.Arg273Lys Single submitter ⚠
- p.Arg323Trp Single submitter ⚠
- p.Arg509Gln Single submitter ⚠
- p.Arg534Cys Single submitter ⚠
- p.Arg534His Single submitter ⚠
- p.Arg546Lys Single submitter ⚠
- p.Arg59Ser Single submitter ⚠
- p.Arg613Cys Single submitter ⚠
- p.Arg616His Single submitter ⚠
- p.Arg795Cys Single submitter ⚠
- p.Arg807Ser Single submitter ⚠
- p.Arg893Gln Single submitter ⚠
- p.Asn1257His Single submitter ⚠
- p.Asn242Ser Single submitter ⚠
- p.Asn378Ser Single submitter ⚠
- p.Asn552His Single submitter ⚠
- p.Asn749Lys Single submitter ⚠
- p.Asn942Lys Single submitter ⚠
- p.Asp1011Gly Single submitter ⚠
- p.Asp1032Val Single submitter ⚠
- p.Asp1033Glu Single submitter ⚠
- p.Asp1108Gly Single submitter ⚠
- p.Asp1124Glu Single submitter ⚠
- p.Asp143Gly Single submitter ⚠
- p.Asp204Asn Single submitter ⚠
- p.Asp213Glu Single submitter ⚠
- p.Asp515Asn Single submitter ⚠
- p.Asp559Val Single submitter ⚠
- p.Asp71Gly Single submitter ⚠
- p.Asp722Gly Single submitter ⚠
- p.Cys397Phe Single submitter ⚠
- p.Cys862Tyr Single submitter ⚠
- p.Cys944Ser Single submitter ⚠
- p.Cys981Tyr Single submitter ⚠
- p.Gln1205Arg Single submitter ⚠
- p.Gln1229His Single submitter ⚠
- p.Gln388His Single submitter ⚠
- p.Gln444His Single submitter ⚠
- p.Gln617Arg Single submitter ⚠
- p.Gln792Arg Single submitter ⚠
- p.Gln792Lys Single submitter ⚠
- p.Gln886Lys Single submitter ⚠
- p.Glu1068Lys Single submitter ⚠
- p.Glu1070Lys Single submitter ⚠
- p.Glu1180Lys Single submitter ⚠
- p.Glu466Lys Single submitter ⚠
- p.Glu648Gly Single submitter ⚠
- p.Glu651Lys Single submitter ⚠
- p.Glu669Lys Single submitter ⚠
- p.Glu672Lys Single submitter ⚠
- p.Glu769Val Single submitter ⚠
- p.Glu837Lys Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.Glu90Gln Single submitter ⚠
- p.Glu994Lys Single submitter ⚠
- p.Gly328Arg Single submitter ⚠
- p.Gly364Cys Single submitter ⚠
- p.Gly364Ser Single submitter ⚠
- p.Gly458Asp Single submitter ⚠
- p.Gly484Arg Single submitter ⚠
- p.Gly548Arg Single submitter ⚠
- p.Gly627Trp Single submitter ⚠
- p.Gly6Ser Single submitter ⚠
- p.Gly796Glu Single submitter ⚠
- p.Gly804Glu Single submitter ⚠
- p.His10Asn Single submitter ⚠
- p.His327Tyr Single submitter ⚠
- p.His343Tyr Single submitter ⚠
- p.His361Tyr Single submitter ⚠
- p.His926Gln Single submitter ⚠
- p.Ile1076Thr Single submitter ⚠
- p.Ile1143Thr Single submitter ⚠
- p.Ile1228Thr Single submitter ⚠
- p.Ile155Val Single submitter ⚠
- p.Ile347Val Single submitter ⚠
- p.Ile38Thr Single submitter ⚠
- p.Ile519Met Single submitter ⚠
- p.Ile687Val Single submitter ⚠
- p.Ile706Leu Single submitter ⚠
- p.Ile706Thr Single submitter ⚠
- p.Leu1024Val Single submitter ⚠
- p.Leu1235Pro Single submitter ⚠
- p.Leu1269Phe Single submitter ⚠
- p.Leu233Val Single submitter ⚠
- p.Leu456Val Single submitter ⚠
- p.Leu813Pro Single submitter ⚠
- p.Leu863Ser Single submitter ⚠
- p.Leu911Met Single submitter ⚠
- p.Leu927Ile Single submitter ⚠
- p.Lys101Glu Single submitter ⚠
- p.Lys105Arg Single submitter ⚠
- p.Lys1305Asn Single submitter ⚠
- p.Lys192Gln Single submitter ⚠
- p.Lys250Asn Single submitter ⚠
- p.Lys277Arg Single submitter ⚠
- p.Lys470Glu Single submitter ⚠
- p.Lys589Glu Single submitter ⚠
- p.Lys60Arg Single submitter ⚠
- p.Lys693Thr Single submitter ⚠
- p.Lys697Thr Single submitter ⚠
- p.Lys752Arg Single submitter ⚠
- p.Lys89Gln Single submitter ⚠
- p.Lys99Glu Single submitter ⚠
- p.Met1149Val Single submitter ⚠
- p.Met1186Val Single submitter ⚠
- p.Met1207Val Single submitter ⚠
- p.Met180Thr Single submitter ⚠
- p.Met908Arg Single submitter ⚠
- p.Phe1239Cys Single submitter ⚠
- p.Phe1239Leu Single submitter ⚠
- p.Phe318Leu Single submitter ⚠
- p.Pro1089Leu Single submitter ⚠
- p.Pro1132Leu Single submitter ⚠
- p.Pro1225Ser Single submitter ⚠
- p.Pro1277Leu Single submitter ⚠
- p.Pro1317Ser Single submitter ⚠
- p.Pro226Thr Single submitter ⚠
- p.Pro27Ser Single submitter ⚠
- p.Pro453Ser Single submitter ⚠
- p.Pro522Ser Single submitter ⚠
- p.Pro716Thr Single submitter ⚠
- p.Pro832Leu Single submitter ⚠
- p.Ser141Cys Single submitter ⚠
- p.Ser265Asn Single submitter ⚠
- p.Ser268Leu Single submitter ⚠
- p.Ser30Thr Single submitter ⚠
- p.Ser337Thr Single submitter ⚠
- p.Ser53Asn Single submitter ⚠
- p.Ser65Thr Single submitter ⚠
- p.Ser764Pro Single submitter ⚠
- p.Ser823Phe Single submitter ⚠
- p.Ser931Thr Single submitter ⚠
- p.Ser954Phe Single submitter ⚠
- p.Thr142Ala Single submitter ⚠
- p.Thr387Ile Single submitter ⚠
- p.Thr391Ile Single submitter ⚠
- p.Thr562Asn Single submitter ⚠
- p.Thr79Pro Single submitter ⚠
- p.Thr916Ile Single submitter ⚠
- p.Thr987Ile Single submitter ⚠
- p.Tyr306His Single submitter ⚠
- p.Tyr786Ser Single submitter ⚠
- p.Tyr843Cys Single submitter ⚠
- p.Val1060Glu Single submitter ⚠
- p.Val1083Ile Single submitter ⚠
- p.Val18Ile Single submitter ⚠
- p.Val382Ile Single submitter ⚠
- p.Val402Glu Single submitter ⚠
- p.Val553Met Single submitter ⚠
- p.Val573Ile Single submitter ⚠
- p.Val61Phe Single submitter ⚠
- p.Glu1195Asp No assertion criteria myoepithelial tumor ⚠