CLTA — 29 ClinVar variants
All ClinVar germline CLTA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
2 Benign · 27 Uncertain significance
Full CLTA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLTA c.486-2284G>A Uncertain significance Single submitter
- CLTA c.486-971A>G Uncertain significance Single submitter
- CLTA p.Ala11Gly Uncertain significance Single submitter
- CLTA p.Ala51Thr Uncertain significance Single submitter
- CLTA p.Arg102Gln Uncertain significance Single submitter
- CLTA p.Arg129Gln Uncertain significance Single submitter
- CLTA p.Gln99Arg Uncertain significance Single submitter
- CLTA p.Glu50Val Uncertain significance Single submitter
- CLTA p.Gly71Val Uncertain significance Single submitter
- CLTA p.Ile140Met Uncertain significance Single submitter
- CLTA p.Ile97Val Uncertain significance Single submitter
- CLTA p.Pro14Ala Uncertain significance Single submitter
- CLTA p.Ser202Cys Uncertain significance Single submitter
- CLTA p.Thr179Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CLTA p.Ala18Thr Uncertain significance Single submitter
- CLTA p.Ala214Pro Uncertain significance Single submitter
- CLTA p.Ala51Val Uncertain significance Single submitter
- CLTA p.Arg129Trp Uncertain significance Single submitter
- CLTA p.Arg183Gln Uncertain significance Single submitter
- CLTA p.Asp151His Uncertain significance Single submitter
- CLTA p.Gln104His Uncertain significance Single submitter
- CLTA p.Glu134Lys Uncertain significance Single submitter
- CLTA p.Glu166Ala Uncertain significance Single submitter
- CLTA p.Glu180Asp Uncertain significance Single submitter
- CLTA p.Gly61Arg Uncertain significance Single submitter
- CLTA p.Gly8Arg Uncertain significance Single submitter
- CLTA p.Ser93Arg Uncertain significance Single submitter
All CLTA variants
Benign 2
- c.256-6G>A Multiple submitters
- p.Arg129= Single submitter
Uncertain significance 27
- c.486-2284G>A Single submitter ⚠
- c.486-971A>G Single submitter ⚠
- p.Ala11Gly Single submitter ⚠
- p.Ala18Thr Single submitter ⚠
- p.Ala214Pro Single submitter ⚠
- p.Ala51Thr Single submitter ⚠
- p.Ala51Val Single submitter ⚠
- p.Arg102Gln Single submitter ⚠
- p.Arg129Gln Single submitter ⚠
- p.Arg129Trp Single submitter ⚠
- p.Arg183Gln Single submitter ⚠
- p.Asp151His Single submitter ⚠
- p.Gln104His Single submitter ⚠
- p.Gln99Arg Single submitter ⚠
- p.Glu134Lys Single submitter ⚠
- p.Glu166Ala Single submitter ⚠
- p.Glu180Asp Single submitter ⚠
- p.Glu50Val Single submitter ⚠
- p.Gly61Arg Single submitter ⚠
- p.Gly71Val Single submitter ⚠
- p.Gly8Arg Single submitter ⚠
- p.Ile140Met Single submitter ⚠
- p.Ile97Val Single submitter ⚠
- p.Pro14Ala Single submitter ⚠
- p.Ser202Cys Single submitter ⚠
- p.Ser93Arg Single submitter ⚠
- p.Thr179Ile Single submitter ⚠