CLTB — 28 ClinVar variants
All ClinVar germline CLTB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
28 Uncertain significance
Full CLTB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLTB p.Ala15Val Uncertain significance Single submitter
- CLTB p.Arg104His Uncertain significance Single submitter
- CLTB p.Arg107Gln Uncertain significance Single submitter
- CLTB p.Arg113Trp Uncertain significance Single submitter
- CLTB p.Arg129Gln Uncertain significance Single submitter
- CLTB p.Arg142Cys Uncertain significance Single submitter
- CLTB p.Arg155Trp Uncertain significance Single submitter
- CLTB p.Arg216Cys Uncertain significance Single submitter
- CLTB p.Cys209Tyr Uncertain significance Single submitter
- CLTB p.Gln163Arg Uncertain significance Single submitter
- CLTB p.Glu32Gln Uncertain significance Single submitter
- CLTB p.Gly49Ala Uncertain significance Single submitter
- CLTB p.Ile38Leu Uncertain significance Single submitter
- CLTB p.Met68Arg Uncertain significance Single submitter
- CLTB p.Ser10Trp Uncertain significance Single submitter
- CLTB p.Ser11Leu Uncertain significance Single submitter
- CLTB p.Thr124Met Uncertain significance Single submitter
- CLTB p.Tyr87His Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CLTB variants
Uncertain significance 28
- p.Ala15Val Single submitter ⚠
- p.Ala196Thr Single submitter
- p.Arg104His Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg113Trp Single submitter ⚠
- p.Arg129Gln Single submitter ⚠
- p.Arg142Cys Single submitter ⚠
- p.Arg155Trp Single submitter ⚠
- p.Arg216Cys Single submitter ⚠
- p.Asp41Tyr Single submitter ⚠
- p.Cys209Tyr Single submitter ⚠
- p.Gln163Arg Single submitter ⚠
- p.Glu177Lys Single submitter
- p.Glu21Gln Single submitter
- p.Glu32Gln Single submitter ⚠
- p.Glu34Asp Single submitter
- p.Glu42Lys Single submitter
- p.Gly49Ala Single submitter ⚠
- p.Ile38Leu Single submitter ⚠
- p.Lys149Glu Single submitter ⚠
- p.Met220Thr Single submitter ⚠
- p.Met68Arg Single submitter ⚠
- p.Phe179Leu Single submitter ⚠
- p.Phe8Leu Single submitter ⚠
- p.Ser10Trp Single submitter ⚠
- p.Ser11Leu Single submitter ⚠
- p.Thr124Met Single submitter ⚠
- p.Tyr87His Single submitter ⚠