CLU — 23 ClinVar variants
All ClinVar germline CLU variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1 flagged for review →
9 Benign · 14 Likely benign
Full CLU gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 1
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All CLU variants
Benign 9
- p.Asp328= Multiple submitters
- p.Asp328Asn Multiple submitters
- p.Pro318= Multiple submitters
- p.Ser396Leu Multiple submitters ⚠
- p.Tyr41= Multiple submitters
- c.417+8G>C Single submitter
- p.Asp397= Single submitter
- p.Val128Ile Single submitter
- p.His263= No assertion criteria CLU-related disorder
Likely benign 14
- p.Ala438= Multiple submitters
- p.Thr203Ile Multiple submitters Alzheimer disease
- p.Asn64= Single submitter
- p.Asp188= Single submitter
- p.His252= Single submitter
- p.Thr25= Single submitter
- p.Tyr235= Single submitter
- p.Val333= Single submitter
- p.Val398Ile Single submitter
- c.*9T>C No assertion criteria CLU-related disorder
- p.Arg182His No assertion criteria CLU-related disorder
- p.Lys40= No assertion criteria CLU-related disorder
- p.Val20= No assertion criteria CLU-related disorder
- p.Val406= No assertion criteria CLU-related disorder