CLUL1 — 62 ClinVar variants
All ClinVar germline CLUL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
1 Likely benign · 61 Uncertain significance
Full CLUL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLUL1 p.Ala21Thr Uncertain significance Single submitter
- CLUL1 p.Ala52Pro Uncertain significance Single submitter
- CLUL1 p.Arg302Gly Uncertain significance Single submitter
- CLUL1 p.Arg302Thr Uncertain significance Single submitter
- CLUL1 p.Asn257Ser Uncertain significance Single submitter
- CLUL1 p.Asp309Tyr Uncertain significance Single submitter
- CLUL1 p.Asp344Glu Uncertain significance Single submitter
- CLUL1 p.Cys11Phe Uncertain significance Single submitter
- CLUL1 p.Cys20Gly Uncertain significance Single submitter
- CLUL1 p.Gln132Pro Uncertain significance Single submitter
- CLUL1 p.Gln176Arg Uncertain significance Single submitter
- CLUL1 p.Gln186Arg Uncertain significance Single submitter
- CLUL1 p.Gln207Pro Uncertain significance Single submitter
- CLUL1 p.Gln211Arg Uncertain significance Single submitter
- CLUL1 p.Gln214Glu Uncertain significance Single submitter
- CLUL1 p.Gln310Arg Uncertain significance Single submitter
- CLUL1 p.Gln359Arg Uncertain significance Single submitter
- CLUL1 p.Glu121Gln Uncertain significance Single submitter
- CLUL1 p.Glu342Gln Uncertain significance Single submitter
- CLUL1 p.Glu345Lys Uncertain significance Single submitter
- CLUL1 p.Glu443Gly Uncertain significance Single submitter
- CLUL1 p.Glu69Asp Uncertain significance Single submitter
- CLUL1 p.Gly290Arg Uncertain significance Single submitter
- CLUL1 p.Gly411Glu Uncertain significance Single submitter
- CLUL1 p.Gly41Glu Uncertain significance Single submitter
- CLUL1 p.Ile149Leu Uncertain significance Single submitter
- CLUL1 p.Ile218Val Uncertain significance Single submitter
- CLUL1 p.Ile30Ser Uncertain significance Single submitter
- CLUL1 p.Ile30Val Uncertain significance Single submitter
- CLUL1 p.Ile402Val Uncertain significance Single submitter
- CLUL1 p.Leu120Pro Uncertain significance Single submitter
- CLUL1 p.Leu194Val Uncertain significance Single submitter
- CLUL1 p.Lys295Asn Uncertain significance Single submitter
- CLUL1 p.Lys324Glu Uncertain significance Single submitter
- CLUL1 p.Met205Ile Uncertain significance Single submitter
- CLUL1 p.Met296Leu Uncertain significance Single submitter
- CLUL1 p.Met421Thr Uncertain significance Single submitter
- CLUL1 p.Met74Arg Uncertain significance Single submitter
- CLUL1 p.Met74Ile Uncertain significance Single submitter
- CLUL1 p.Pro155Ala Uncertain significance Single submitter
- CLUL1 p.Pro226Leu Uncertain significance Single submitter
- CLUL1 p.Pro236Leu Uncertain significance Single submitter
- CLUL1 p.Pro337Thr Uncertain significance Single submitter
- CLUL1 p.Ser136Cys Uncertain significance Single submitter
- CLUL1 p.Ser193Cys Uncertain significance Single submitter
- CLUL1 p.Ser193Thr Uncertain significance Single submitter
- CLUL1 p.Ser265Asn Uncertain significance Single submitter
- CLUL1 p.Ser265Gly Uncertain significance Single submitter
- CLUL1 p.Ser430Cys Uncertain significance Single submitter
- CLUL1 p.Ser445Phe Uncertain significance Single submitter
- CLUL1 p.Thr224Pro Uncertain significance Single submitter
- CLUL1 p.Thr23Ala Uncertain significance Single submitter
- CLUL1 p.Trp135Arg Uncertain significance Single submitter
- CLUL1 p.Val201Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CLUL1 variants
Likely benign 1
- p.Val352Ile Single submitter
Uncertain significance 61
- p.Ala21Thr Single submitter ⚠
- p.Ala52Pro Single submitter ⚠
- p.Arg302Gly Single submitter ⚠
- p.Arg302Thr Single submitter ⚠
- p.Asn257Ser Single submitter ⚠
- p.Asp309Tyr Single submitter ⚠
- p.Asp344Glu Single submitter ⚠
- p.Cys116Arg Single submitter ⚠
- p.Cys11Phe Single submitter ⚠
- p.Cys20Gly Single submitter ⚠
- p.Gln132Pro Single submitter ⚠
- p.Gln176Arg Single submitter ⚠
- p.Gln186Arg Single submitter ⚠
- p.Gln207Pro Single submitter ⚠
- p.Gln211Arg Single submitter ⚠
- p.Gln214Glu Single submitter ⚠
- p.Gln310Arg Single submitter ⚠
- p.Gln359Arg Single submitter ⚠
- p.Glu121Gln Single submitter ⚠
- p.Glu342Gln Single submitter ⚠
- p.Glu345Lys Single submitter ⚠
- p.Glu443Gly Single submitter ⚠
- p.Glu69Asp Single submitter ⚠
- p.Gly290Arg Single submitter ⚠
- p.Gly383Val Single submitter
- p.Gly411Glu Single submitter ⚠
- p.Gly41Glu Single submitter ⚠
- p.Ile149Leu Single submitter ⚠
- p.Ile218Val Single submitter ⚠
- p.Ile30Ser Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Ile402Val Single submitter ⚠
- p.Leu120Pro Single submitter ⚠
- p.Leu194Val Single submitter ⚠
- p.Leu90His Single submitter
- p.Lys295Asn Single submitter ⚠
- p.Lys324Glu Single submitter ⚠
- p.Met205Ile Single submitter ⚠
- p.Met296Leu Single submitter ⚠
- p.Met421Thr Single submitter ⚠
- p.Met59Thr Single submitter ⚠
- p.Met63Thr Single submitter
- p.Met74Arg Single submitter ⚠
- p.Met74Ile Single submitter ⚠
- p.Pro155Ala Single submitter ⚠
- p.Pro226Leu Single submitter ⚠
- p.Pro236Leu Single submitter ⚠
- p.Pro337Thr Single submitter ⚠
- p.Ser136Cys Single submitter ⚠
- p.Ser193Cys Single submitter ⚠
- p.Ser193Thr Single submitter ⚠
- p.Ser219Pro Single submitter ⚠
- p.Ser265Asn Single submitter ⚠
- p.Ser265Gly Single submitter ⚠
- p.Ser430Cys Single submitter ⚠
- p.Ser445Phe Single submitter ⚠
- p.Thr224Pro Single submitter ⚠
- p.Thr23Ala Single submitter ⚠
- p.Trp135Arg Single submitter ⚠
- p.Val201Ile Single submitter ⚠
- p.Val94Asp Single submitter