CLVS1 — 29 ClinVar variants
All ClinVar germline CLVS1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Likely benign · 28 Uncertain significance
Full CLVS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLVS1 p.Ala28Ser Uncertain significance Single submitter
- CLVS1 p.Asn178Ser Uncertain significance Single submitter
- CLVS1 p.Asn346Thr Uncertain significance Single submitter
- CLVS1 p.Asp106Asn Uncertain significance Single submitter
- CLVS1 p.Asp114Asn Uncertain significance Single submitter
- CLVS1 p.Asp291Asn Uncertain significance Single submitter
- CLVS1 p.Asp294Asn Uncertain significance Single submitter
- CLVS1 p.Gln260Glu Uncertain significance Single submitter
- CLVS1 p.Gln54His Uncertain significance Single submitter
- CLVS1 p.Glu343Gln Uncertain significance Single submitter
- CLVS1 p.Gly117Ser Uncertain significance Single submitter
- CLVS1 p.Gly137Ser Uncertain significance Single submitter
- CLVS1 p.Ile181Val Uncertain significance Single submitter
- CLVS1 p.Leu42Pro Uncertain significance Single submitter
- CLVS1 p.Pro173Leu Uncertain significance Single submitter
- CLVS1 p.Pro199Leu Uncertain significance Single submitter
- CLVS1 p.Thr15Pro Uncertain significance Single submitter
- CLVS1 p.Thr286Met Uncertain significance Single submitter
- CLVS1 p.Thr34Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CLVS1 p.Arg39Cys Uncertain significance Single submitter
- CLVS1 p.Asn153Asp Uncertain significance Single submitter
- CLVS1 p.Asn224Ser Uncertain significance Single submitter
- CLVS1 p.Glu171Lys Uncertain significance Single submitter
- CLVS1 p.Ile35Thr Uncertain significance Single submitter
- CLVS1 p.Leu77Met Uncertain significance Single submitter
- CLVS1 p.Ser154Cys Uncertain significance Single submitter
All CLVS1 variants
Likely benign 1
- p.Asn147= Single submitter
Uncertain significance 28
- p.Ala28Ser Single submitter ⚠
- p.Arg39Cys Single submitter ⚠
- p.Asn153Asp Single submitter ⚠
- p.Asn178Ser Single submitter ⚠
- p.Asn224Ser Single submitter ⚠
- p.Asn346Thr Single submitter ⚠
- p.Asp106Asn Single submitter ⚠
- p.Asp114Asn Single submitter ⚠
- p.Asp291Asn Single submitter ⚠
- p.Asp294Asn Single submitter ⚠
- p.Gln260Glu Single submitter ⚠
- p.Gln54His Single submitter ⚠
- p.Glu171Lys Single submitter ⚠
- p.Glu343Gln Single submitter ⚠
- p.Gly117Ser Single submitter ⚠
- p.Gly137Ser Single submitter ⚠
- p.Ile181Ser Single submitter
- p.Ile181Val Single submitter ⚠
- p.Ile35Thr Single submitter ⚠
- p.Leu235Phe Single submitter
- p.Leu42Pro Single submitter ⚠
- p.Leu77Met Single submitter ⚠
- p.Pro173Leu Single submitter ⚠
- p.Pro199Leu Single submitter ⚠
- p.Ser154Cys Single submitter ⚠
- p.Thr15Pro Single submitter ⚠
- p.Thr286Met Single submitter ⚠
- p.Thr34Ala Single submitter ⚠