CLVS2 — 24 ClinVar variants
All ClinVar germline CLVS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 23 Uncertain significance
Full CLVS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLVS2 p.Ala146Thr Uncertain significance Single submitter
- CLVS2 p.Arg138Gly Uncertain significance Single submitter
- CLVS2 p.Arg215Trp Uncertain significance Single submitter
- CLVS2 p.Arg48Cys Uncertain significance Single submitter
- CLVS2 p.Glu316Gly Uncertain significance Single submitter
- CLVS2 p.His241Asn Uncertain significance Single submitter
- CLVS2 p.Leu18Gln Uncertain significance Single submitter
- CLVS2 p.Leu58Val Uncertain significance Single submitter
- CLVS2 p.Lys314Arg Uncertain significance Single submitter
- CLVS2 p.Met283Ile Uncertain significance Single submitter
- CLVS2 p.Met283Thr Uncertain significance Single submitter
- CLVS2 p.Met85Leu Uncertain significance Single submitter
- CLVS2 p.Pro151Ala Uncertain significance Single submitter
- CLVS2 p.Thr212Ser Uncertain significance Single submitter
- CLVS2 p.Thr264Ser Uncertain significance Single submitter
- CLVS2 p.Val213Met Uncertain significance Single submitter
- CLVS2 p.Val288Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CLVS2 p.Ala139Gly Uncertain significance Single submitter
- CLVS2 p.Asp272Gly Uncertain significance Single submitter
- CLVS2 p.Glu19Gln Uncertain significance Single submitter
- CLVS2 p.Leu180Met Uncertain significance Single submitter
- CLVS2 p.Phe169Leu Uncertain significance Single submitter
- CLVS2 p.Ser9Cys Uncertain significance Single submitter
All CLVS2 variants
Likely benign 1
- p.Ala193= Single submitter
Uncertain significance 23
- p.Ala139Gly Single submitter ⚠
- p.Ala146Thr Single submitter ⚠
- p.Arg138Gly Single submitter ⚠
- p.Arg215Trp Single submitter ⚠
- p.Arg48Cys Single submitter ⚠
- p.Asp272Gly Single submitter ⚠
- p.Glu19Gln Single submitter ⚠
- p.Glu316Gly Single submitter ⚠
- p.His241Asn Single submitter ⚠
- p.Leu180Met Single submitter ⚠
- p.Leu18Gln Single submitter ⚠
- p.Leu58Val Single submitter ⚠
- p.Lys314Arg Single submitter ⚠
- p.Met283Ile Single submitter ⚠
- p.Met283Thr Single submitter ⚠
- p.Met85Leu Single submitter ⚠
- p.Phe169Leu Single submitter ⚠
- p.Pro151Ala Single submitter ⚠
- p.Ser9Cys Single submitter ⚠
- p.Thr212Ser Single submitter ⚠
- p.Thr264Ser Single submitter ⚠
- p.Val213Met Single submitter ⚠
- p.Val288Ile Single submitter ⚠