CLYBL — 61 ClinVar variants
All ClinVar germline CLYBL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
2 Likely benign · 59 Uncertain significance
Full CLYBL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLYBL p.Ala116Val Uncertain significance Single submitter
- CLYBL p.Ala13Asp Uncertain significance Single submitter
- CLYBL p.Ala17Ser Uncertain significance Single submitter
- CLYBL p.Ala17Thr Uncertain significance Single submitter
- CLYBL p.Ala23Val Uncertain significance Single submitter
- CLYBL p.Ala300Pro Uncertain significance Single submitter
- CLYBL p.Arg11Gly Uncertain significance Single submitter
- CLYBL p.Arg208Gln Uncertain significance Single submitter
- CLYBL p.Arg226Gln Uncertain significance Single submitter
- CLYBL p.Arg259Gln Uncertain significance Single submitter
- CLYBL p.Arg45Gln Uncertain significance Single submitter
- CLYBL p.Arg4Ser Uncertain significance Single submitter
- CLYBL p.Arg87Gln Uncertain significance Single submitter
- CLYBL p.Arg89Thr Uncertain significance Single submitter
- CLYBL p.Asp198His Uncertain significance Single submitter
- CLYBL p.Asp242Asn Uncertain significance Single submitter
- CLYBL p.Asp320Val Uncertain significance Single submitter
- CLYBL p.Asp73Tyr Uncertain significance Single submitter
- CLYBL p.Asp76Asn Uncertain significance Single submitter
- CLYBL p.Glu75Val Uncertain significance Single submitter
- CLYBL p.Ile232Thr Uncertain significance Single submitter
- CLYBL p.Leu123Ile Uncertain significance Single submitter
- CLYBL p.Leu18Val Uncertain significance Single submitter
- CLYBL p.Leu243Met Uncertain significance Single submitter
- CLYBL p.Leu5Val Uncertain significance Single submitter
- CLYBL p.Lys338Arg Uncertain significance Single submitter
- CLYBL p.Met264Thr Uncertain significance Single submitter
- CLYBL p.Pro136Arg Uncertain significance Single submitter
- CLYBL p.Thr219Asn Uncertain significance Single submitter
- CLYBL p.Thr332Met Uncertain significance Single submitter
- CLYBL p.Trp293Cys Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- CLYBL p.Ala13Val Uncertain significance Single submitter
- CLYBL p.Ala16Val Uncertain significance Single submitter
- CLYBL p.Ala17Val Uncertain significance Single submitter
- CLYBL p.Ala213Ser Uncertain significance Single submitter
- CLYBL p.Ala235Gly Uncertain significance Single submitter
- CLYBL p.Ala263Thr Uncertain significance Single submitter
- CLYBL p.Ala2Gly Uncertain significance Single submitter
- CLYBL p.Ala311Ser Uncertain significance Single submitter
- CLYBL p.Ala334Thr Uncertain significance Single submitter
- CLYBL p.Ala9Val Uncertain significance Single submitter
- CLYBL p.Arg127Gln Uncertain significance Single submitter
- CLYBL p.Arg4Cys Uncertain significance Single submitter
- CLYBL p.Gln257Leu Uncertain significance Single submitter
- CLYBL p.Gln315Pro Uncertain significance Single submitter
- CLYBL p.Glu103Asp Uncertain significance Single submitter
- CLYBL p.Glu139Asp Uncertain significance Single submitter
- CLYBL p.Gly157Ser Uncertain significance Single submitter
- CLYBL p.Gly190Trp Uncertain significance Single submitter
- CLYBL p.Leu323Ser Uncertain significance Single submitter
- CLYBL p.Leu94Val Uncertain significance Single submitter
- CLYBL p.Pro168Ser Uncertain significance Single submitter
- CLYBL p.Pro288Leu Uncertain significance Single submitter
- CLYBL p.Ser215Asn Uncertain significance Single submitter
- CLYBL p.Ser215Gly Uncertain significance Single submitter
- CLYBL p.Ser317Ile Uncertain significance Single submitter
- CLYBL p.Val189Ala Uncertain significance Single submitter
- CLYBL p.Val189Ile Likely benign Single submitter
- CLYBL p.Val201Ile Uncertain significance Single submitter
- CLYBL p.Val279Leu Uncertain significance Single submitter
All CLYBL variants
Likely benign 2
- p.Arg259Ter Single submitter
- p.Val189Ile Single submitter ⚠
Uncertain significance 59
- p.Ala116Val Single submitter ⚠
- p.Ala13Asp Single submitter ⚠
- p.Ala13Val Single submitter ⚠
- p.Ala16Val Single submitter ⚠
- p.Ala17Ser Single submitter ⚠
- p.Ala17Thr Single submitter ⚠
- p.Ala17Val Single submitter ⚠
- p.Ala213Ser Single submitter ⚠
- p.Ala235Gly Single submitter ⚠
- p.Ala23Val Single submitter ⚠
- p.Ala263Thr Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Ala300Pro Single submitter ⚠
- p.Ala311Ser Single submitter ⚠
- p.Ala334Thr Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg11Gly Single submitter ⚠
- p.Arg127Gln Single submitter ⚠
- p.Arg208Gln Single submitter ⚠
- p.Arg226Gln Single submitter ⚠
- p.Arg259Gln Single submitter ⚠
- p.Arg45Gln Single submitter ⚠
- p.Arg4Cys Single submitter ⚠
- p.Arg4Ser Single submitter ⚠
- p.Arg87Gln Single submitter ⚠
- p.Arg89Thr Single submitter ⚠
- p.Asp198His Single submitter ⚠
- p.Asp242Asn Single submitter ⚠
- p.Asp320Val Single submitter ⚠
- p.Asp73Tyr Single submitter ⚠
- p.Asp76Asn Single submitter ⚠
- p.Gln257Leu Single submitter ⚠
- p.Gln315Pro Single submitter ⚠
- p.Glu103Asp Single submitter ⚠
- p.Glu139Asp Single submitter ⚠
- p.Glu75Val Single submitter ⚠
- p.Gly157Ser Single submitter ⚠
- p.Gly190Trp Single submitter ⚠
- p.Ile232Thr Single submitter ⚠
- p.Leu123Ile Single submitter ⚠
- p.Leu18Val Single submitter ⚠
- p.Leu243Met Single submitter ⚠
- p.Leu323Ser Single submitter ⚠
- p.Leu5Val Single submitter ⚠
- p.Leu94Val Single submitter ⚠
- p.Lys338Arg Single submitter ⚠
- p.Met264Thr Single submitter ⚠
- p.Pro136Arg Single submitter ⚠
- p.Pro168Ser Single submitter ⚠
- p.Pro288Leu Single submitter ⚠
- p.Ser215Asn Single submitter ⚠
- p.Ser215Gly Single submitter ⚠
- p.Ser317Ile Single submitter ⚠
- p.Thr219Asn Single submitter ⚠
- p.Thr332Met Single submitter ⚠
- p.Trp293Cys Single submitter ⚠
- p.Val189Ala Single submitter ⚠
- p.Val201Ile Single submitter ⚠
- p.Val279Leu Single submitter ⚠