CMKLR1 — 59 ClinVar variants
All ClinVar germline CMKLR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
1 Benign · 1 Likely benign · 57 Uncertain significance
Full CMKLR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CMKLR1 p.Ala100Thr Uncertain significance Single submitter
- CMKLR1 p.Ala288Val Uncertain significance Single submitter
- CMKLR1 p.Ala305Pro Uncertain significance Single submitter
- CMKLR1 p.Ala65Val Uncertain significance Single submitter
- CMKLR1 p.Arg137His Uncertain significance Single submitter
- CMKLR1 p.Arg249His Uncertain significance Single submitter
- CMKLR1 p.Arg251Leu Uncertain significance Single submitter
- CMKLR1 p.Arg37Gly Uncertain significance Single submitter
- CMKLR1 p.Asn336Ser Uncertain significance Single submitter
- CMKLR1 p.Asn360Asp Uncertain significance Single submitter
- CMKLR1 p.Asp341Ala Uncertain significance Single submitter
- CMKLR1 p.Cys160Arg Uncertain significance Single submitter
- CMKLR1 p.Gly108Arg Uncertain significance Single submitter
- CMKLR1 p.Gly199Arg Uncertain significance Single submitter
- CMKLR1 p.Gly199Glu Uncertain significance Single submitter
- CMKLR1 p.Gly343Val Uncertain significance Single submitter
- CMKLR1 p.His184Arg Uncertain significance Single submitter
- CMKLR1 p.His277Asp Uncertain significance Single submitter
- CMKLR1 p.Ile163Leu Uncertain significance Single submitter
- CMKLR1 p.Ile163Val Uncertain significance Single submitter
- CMKLR1 p.Ile306Val Uncertain significance Single submitter
- CMKLR1 p.Leu298Phe Uncertain significance Single submitter
- CMKLR1 p.Leu53Phe Uncertain significance Single submitter
- CMKLR1 p.Lys256Asn Uncertain significance Single submitter
- CMKLR1 p.Met111Val Uncertain significance Single submitter
- CMKLR1 p.Met311Val Uncertain significance Single submitter
- CMKLR1 p.Met75Val Uncertain significance Single submitter
- CMKLR1 p.Phe168Ile Uncertain significance Single submitter
- CMKLR1 p.Phe168Val Uncertain significance Single submitter
- CMKLR1 p.Phe193Val Uncertain significance Single submitter
- CMKLR1 p.Pro275His Uncertain significance Single submitter
- CMKLR1 p.Pro275Leu Uncertain significance Single submitter
- CMKLR1 p.Pro33Leu Uncertain significance Single submitter
- CMKLR1 p.Ser126Arg Uncertain significance Single submitter
- CMKLR1 p.Ser202Leu Uncertain significance Single submitter
- CMKLR1 p.Ser345Phe Uncertain significance Single submitter
- CMKLR1 p.Thr109Ser Uncertain significance Single submitter
- CMKLR1 p.Thr255Ala Uncertain significance Single submitter
- CMKLR1 p.Thr354Ala Uncertain significance Single submitter
- CMKLR1 p.Thr354Ile Uncertain significance Single submitter
- CMKLR1 p.Thr363Asn Uncertain significance Single submitter
- CMKLR1 p.Thr363Ile Uncertain significance Single submitter
- CMKLR1 p.Trp203Arg Uncertain significance Single submitter
- CMKLR1 p.Val106Ile Uncertain significance Single submitter
- CMKLR1 p.Val44Ala Uncertain significance Single submitter
- CMKLR1 p.Val44Met Uncertain significance Single submitter
- CMKLR1 p.Val90Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CMKLR1 variants
Benign 1
- p.Met289Ile Multiple submitters
Likely benign 1
- p.Met158Val Single submitter
Uncertain significance 57
- p.Ala100Thr Single submitter ⚠
- p.Ala288Val Single submitter ⚠
- p.Ala305Pro Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Arg137His Single submitter ⚠
- p.Arg178Gln Single submitter
- p.Arg224His Single submitter
- p.Arg249His Single submitter ⚠
- p.Arg251Leu Single submitter ⚠
- p.Arg37Gly Single submitter ⚠
- p.Asn336Ser Single submitter ⚠
- p.Asn360Asp Single submitter ⚠
- p.Asp341Ala Single submitter ⚠
- p.Cys160Arg Single submitter ⚠
- p.Gly108Arg Single submitter ⚠
- p.Gly199Arg Single submitter ⚠
- p.Gly199Glu Single submitter ⚠
- p.Gly343Val Single submitter ⚠
- p.His184Arg Single submitter ⚠
- p.His277Asp Single submitter ⚠
- p.Ile163Leu Single submitter ⚠
- p.Ile163Val Single submitter ⚠
- p.Ile306Val Single submitter ⚠
- p.Leu298Phe Single submitter ⚠
- p.Leu53Phe Single submitter ⚠
- p.Leu92Val Single submitter
- p.Lys256Asn Single submitter ⚠
- p.Met111Val Single submitter ⚠
- p.Met123Val Single submitter ⚠
- p.Met311Val Single submitter ⚠
- p.Met69Val Single submitter ⚠
- p.Met75Val Single submitter ⚠
- p.Phe168Ile Single submitter ⚠
- p.Phe168Val Single submitter ⚠
- p.Phe193Val Single submitter ⚠
- p.Phe270Leu Single submitter ⚠
- p.Pro275His Single submitter ⚠
- p.Pro275Leu Single submitter ⚠
- p.Pro33Leu Single submitter ⚠
- p.Ser126Arg Single submitter ⚠
- p.Ser188Pro Single submitter ⚠
- p.Ser194Arg Single submitter
- p.Ser202Leu Single submitter ⚠
- p.Ser345Phe Single submitter ⚠
- p.Thr109Ser Single submitter ⚠
- p.Thr180Arg Single submitter
- p.Thr255Ala Single submitter ⚠
- p.Thr354Ala Single submitter ⚠
- p.Thr354Ile Single submitter ⚠
- p.Thr363Asn Single submitter ⚠
- p.Thr363Ile Single submitter ⚠
- p.Trp203Arg Single submitter ⚠
- p.Tyr214Cys Single submitter ⚠
- p.Val106Ile Single submitter ⚠
- p.Val44Ala Single submitter ⚠
- p.Val44Met Single submitter ⚠
- p.Val90Ala Single submitter ⚠