CMKLR2 — 56 ClinVar variants
All ClinVar germline CMKLR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Benign · 1 Likely benign · 54 Uncertain significance
Full CMKLR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CMKLR2 p.Ala165Val Uncertain significance Single submitter
- CMKLR2 p.Ala80Asp Uncertain significance Single submitter
- CMKLR2 p.Ala82Val Uncertain significance Single submitter
- CMKLR2 p.Arg176Trp Uncertain significance Single submitter
- CMKLR2 p.Arg202Lys Uncertain significance Single submitter
- CMKLR2 p.Arg236Gln Uncertain significance Single submitter
- CMKLR2 p.Asn182Ser Uncertain significance Single submitter
- CMKLR2 p.Asn190Asp Uncertain significance Single submitter
- CMKLR2 p.Asn300His Uncertain significance Single submitter
- CMKLR2 p.Gln339Arg Uncertain significance Single submitter
- CMKLR2 p.Glu352Val Uncertain significance Single submitter
- CMKLR2 p.Glu6Asp Uncertain significance Single submitter
- CMKLR2 p.Gly170Ser Uncertain significance Single submitter
- CMKLR2 p.Gly55Glu Uncertain significance Single submitter
- CMKLR2 p.Gly64Glu Uncertain significance Single submitter
- CMKLR2 p.His138Arg Uncertain significance Single submitter
- CMKLR2 p.His203Asn Uncertain significance Single submitter
- CMKLR2 p.His203Asp Uncertain significance Single submitter
- CMKLR2 p.His203Gln Uncertain significance Single submitter
- CMKLR2 p.Ile158Leu Uncertain significance Single submitter
- CMKLR2 p.Ile159Thr Uncertain significance Single submitter
- CMKLR2 p.Ile238Thr Uncertain significance Single submitter
- CMKLR2 p.Leu109Met Uncertain significance Single submitter
- CMKLR2 p.Leu128Arg Uncertain significance Single submitter
- CMKLR2 p.Leu288Phe Uncertain significance Single submitter
- CMKLR2 p.Leu292Trp Uncertain significance Single submitter
- CMKLR2 p.Leu299Ser Uncertain significance Single submitter
- CMKLR2 p.Leu92Pro Uncertain significance Single submitter
- CMKLR2 p.Lys346Arg Uncertain significance Single submitter
- CMKLR2 p.Met282Ile Uncertain significance Single submitter
- CMKLR2 p.Phe160Leu Uncertain significance Single submitter
- CMKLR2 p.Ser337Thr Uncertain significance Single submitter
- CMKLR2 p.Trp246Arg Uncertain significance Single submitter
- CMKLR2 p.Val157Ala Uncertain significance Single submitter
- CMKLR2 p.Val179Met Uncertain significance Single submitter
- CMKLR2 p.Val256Ala Uncertain significance Single submitter
- CMKLR2 p.Val50Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CMKLR2 p.Ala172Val Uncertain significance Single submitter
- CMKLR2 p.Arg147Trp Uncertain significance Single submitter
- CMKLR2 p.Arg176Gln Uncertain significance Single submitter
- CMKLR2 p.Arg314Cys Uncertain significance Single submitter
- CMKLR2 p.Arg316Gln Uncertain significance Single submitter
- CMKLR2 p.His141Gln Uncertain significance Single submitter
- CMKLR2 p.Ile58Asn Uncertain significance Single submitter
- CMKLR2 p.Ile60Leu Uncertain significance Single submitter
- CMKLR2 p.Lys68Arg Uncertain significance Single submitter
- CMKLR2 p.Phe127Tyr Uncertain significance Single submitter
- CMKLR2 p.Ser343Pro Uncertain significance Single submitter
- CMKLR2 p.Thr63Met Uncertain significance Single submitter
- CMKLR2 p.Tyr93His Uncertain significance Single submitter
- CMKLR2 p.Val251Leu Uncertain significance Single submitter
- CMKLR2 p.Val319Gly Uncertain significance Single submitter
- CMKLR2 p.Val50Ala Uncertain significance Single submitter
- CMKLR2 p.Val59Ile Uncertain significance Single submitter
All CMKLR2 variants
Benign 1
- p.Ile307Val Multiple submitters
Likely benign 1
- p.Leu288fs Single submitter
Uncertain significance 54
- p.Ala165Val Single submitter ⚠
- p.Ala172Val Single submitter ⚠
- p.Ala80Asp Single submitter ⚠
- p.Ala82Val Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Arg176Gln Single submitter ⚠
- p.Arg176Trp Single submitter ⚠
- p.Arg202Lys Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg314Cys Single submitter ⚠
- p.Arg316Gln Single submitter ⚠
- p.Asn182Ser Single submitter ⚠
- p.Asn190Asp Single submitter ⚠
- p.Asn300His Single submitter ⚠
- p.Gln339Arg Single submitter ⚠
- p.Glu352Val Single submitter ⚠
- p.Glu6Asp Single submitter ⚠
- p.Gly170Ser Single submitter ⚠
- p.Gly55Glu Single submitter ⚠
- p.Gly64Glu Single submitter ⚠
- p.His138Arg Single submitter ⚠
- p.His141Gln Single submitter ⚠
- p.His203Asn Single submitter ⚠
- p.His203Asp Single submitter ⚠
- p.His203Gln Single submitter ⚠
- p.Ile158Leu Single submitter ⚠
- p.Ile159Thr Single submitter ⚠
- p.Ile238Thr Single submitter ⚠
- p.Ile58Asn Single submitter ⚠
- p.Ile60Leu Single submitter ⚠
- p.Leu109Met Single submitter ⚠
- p.Leu128Arg Single submitter ⚠
- p.Leu288Phe Single submitter ⚠
- p.Leu292Trp Single submitter ⚠
- p.Leu299Ser Single submitter ⚠
- p.Leu92Pro Single submitter ⚠
- p.Lys346Arg Single submitter ⚠
- p.Lys68Arg Single submitter ⚠
- p.Met282Ile Single submitter ⚠
- p.Phe127Tyr Single submitter ⚠
- p.Phe160Leu Single submitter ⚠
- p.Ser337Thr Single submitter ⚠
- p.Ser343Pro Single submitter ⚠
- p.Thr63Met Single submitter ⚠
- p.Trp246Arg Single submitter ⚠
- p.Tyr93His Single submitter ⚠
- p.Val157Ala Single submitter ⚠
- p.Val179Met Single submitter ⚠
- p.Val251Leu Single submitter ⚠
- p.Val256Ala Single submitter ⚠
- p.Val319Gly Single submitter ⚠
- p.Val50Ala Single submitter ⚠
- p.Val50Leu Single submitter ⚠
- p.Val59Ile Single submitter ⚠