CMTM4 — 25 ClinVar variants
All ClinVar germline CMTM4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
25 Uncertain significance
Full CMTM4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CMTM4 c.*4764C>A Uncertain significance Single submitter
- CMTM4 p.Arg200His Uncertain significance Single submitter
- CMTM4 p.Asn185Ser Uncertain significance Single submitter
- CMTM4 p.Gly55Val Uncertain significance Single submitter
- CMTM4 p.His145Arg Uncertain significance Single submitter
- CMTM4 p.Ile67Met Uncertain significance Single submitter
- CMTM4 p.Phe169Tyr Uncertain significance Single submitter
- CMTM4 p.Ser35Gly Uncertain significance Single submitter
- CMTM4 p.Val100Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CMTM4 p.Ala160Val Uncertain significance Single submitter
- CMTM4 p.Ala41Val Uncertain significance Single submitter
- CMTM4 p.Arg180His Uncertain significance Single submitter
- CMTM4 p.Arg191Cys Uncertain significance Single submitter
- CMTM4 p.Arg200Cys Uncertain significance Single submitter
- CMTM4 p.Arg205Cys Uncertain significance Single submitter
- CMTM4 p.Cys71Ser Uncertain significance Single submitter
- CMTM4 p.Gln182His Uncertain significance Single submitter
- CMTM4 p.Gln61Arg Uncertain significance Single submitter
- CMTM4 p.His110Gln Uncertain significance Single submitter
- CMTM4 p.Ile135Thr Uncertain significance Single submitter
- CMTM4 p.Leu43Arg Uncertain significance Single submitter
- CMTM4 p.Ser15Pro Uncertain significance Single submitter
- CMTM4 p.Thr192Lys Uncertain significance Single submitter
- CMTM4 p.Val139Leu Uncertain significance Single submitter
- CMTM4 p.Val172Ala Uncertain significance Single submitter
All CMTM4 variants
Uncertain significance 25
- c.*4764C>A Single submitter ⚠
- p.Ala160Val Single submitter ⚠
- p.Ala41Val Single submitter ⚠
- p.Arg180His Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg200Cys Single submitter ⚠
- p.Arg200His Single submitter ⚠
- p.Arg205Cys Single submitter ⚠
- p.Asn185Ser Single submitter ⚠
- p.Cys71Ser Single submitter ⚠
- p.Gln182His Single submitter ⚠
- p.Gln61Arg Single submitter ⚠
- p.Gly55Val Single submitter ⚠
- p.His110Gln Single submitter ⚠
- p.His145Arg Single submitter ⚠
- p.Ile135Thr Single submitter ⚠
- p.Ile67Met Single submitter ⚠
- p.Leu43Arg Single submitter ⚠
- p.Phe169Tyr Single submitter ⚠
- p.Ser15Pro Single submitter ⚠
- p.Ser35Gly Single submitter ⚠
- p.Thr192Lys Single submitter ⚠
- p.Val100Ile Single submitter ⚠
- p.Val139Leu Single submitter ⚠
- p.Val172Ala Single submitter ⚠