CMTM6 — 17 ClinVar variants
All ClinVar germline CMTM6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
17 Uncertain significance
Full CMTM6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CMTM6 p.Ala176Thr Uncertain significance Single submitter
- CMTM6 p.Ala78Ser Uncertain significance Single submitter
- CMTM6 p.Asn182Thr Uncertain significance Single submitter
- CMTM6 p.Gly16Ala Uncertain significance Single submitter
- CMTM6 p.Ile85Met Uncertain significance Single submitter
- CMTM6 p.Leu48Val Uncertain significance Single submitter
- CMTM6 p.Met31Thr Uncertain significance Single submitter
- CMTM6 p.Pro17Thr Uncertain significance Single submitter
- CMTM6 p.Ser105Leu Uncertain significance Single submitter
- CMTM6 p.Val6Gly Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CMTM6 p.Arg160Gln Uncertain significance Single submitter
- CMTM6 p.Arg22Gln Uncertain significance Single submitter
- CMTM6 p.Gly32Val Uncertain significance Single submitter
- CMTM6 p.Ile143Thr Uncertain significance Single submitter
- CMTM6 p.Leu150Phe Uncertain significance Single submitter
- CMTM6 p.Thr11Met Uncertain significance Single submitter
- CMTM6 p.Tyr108Ser Uncertain significance Single submitter
All CMTM6 variants
Uncertain significance 17
- p.Ala176Thr Single submitter ⚠
- p.Ala78Ser Single submitter ⚠
- p.Arg160Gln Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Asn182Thr Single submitter ⚠
- p.Gly16Ala Single submitter ⚠
- p.Gly32Val Single submitter ⚠
- p.Ile143Thr Single submitter ⚠
- p.Ile85Met Single submitter ⚠
- p.Leu150Phe Single submitter ⚠
- p.Leu48Val Single submitter ⚠
- p.Met31Thr Single submitter ⚠
- p.Pro17Thr Single submitter ⚠
- p.Ser105Leu Single submitter ⚠
- p.Thr11Met Single submitter ⚠
- p.Tyr108Ser Single submitter ⚠
- p.Val6Gly Single submitter ⚠