CMTM7 — 23 ClinVar variants
All ClinVar germline CMTM7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
1 Likely benign · 22 Uncertain significance
Full CMTM7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CMTM7 p.Ala150Ser Uncertain significance Single submitter
- CMTM7 p.Ala22Asp Uncertain significance Single submitter
- CMTM7 p.Ala22Val Uncertain significance Single submitter
- CMTM7 p.Ala73Thr Uncertain significance Single submitter
- CMTM7 p.Arg98Gly Uncertain significance Single submitter
- CMTM7 p.Arg98His Uncertain significance Single submitter
- CMTM7 p.Cys62Ser Uncertain significance Single submitter
- CMTM7 p.Gly15Cys Uncertain significance Single submitter
- CMTM7 p.Gly19Arg Uncertain significance Single submitter
- CMTM7 p.Ile128Val Uncertain significance Single submitter
- CMTM7 p.Ile158Leu Uncertain significance Single submitter
- CMTM7 p.Leu110Pro Uncertain significance Single submitter
- CMTM7 p.Leu117Val Uncertain significance Single submitter
- CMTM7 p.Phe146Ser Uncertain significance Single submitter
- CMTM7 p.Ser111Leu Uncertain significance Single submitter
- CMTM7 p.Ser30Arg Uncertain significance Single submitter
- CMTM7 p.Thr11Pro Uncertain significance Single submitter
- CMTM7 p.Val102Leu Uncertain significance Single submitter
- CMTM7 p.Val102Met Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CMTM7 variants
Likely benign 1
- p.Asp84Asn Single submitter
Uncertain significance 22
- p.Ala144Val Single submitter ⚠
- p.Ala150Ser Single submitter ⚠
- p.Ala22Asp Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala73Thr Single submitter ⚠
- p.Arg98Gly Single submitter ⚠
- p.Arg98His Single submitter ⚠
- p.Cys62Ser Single submitter ⚠
- p.Gly15Cys Single submitter ⚠
- p.Gly19Arg Single submitter ⚠
- p.Ile128Val Single submitter ⚠
- p.Ile158Leu Single submitter ⚠
- p.Leu110Pro Single submitter ⚠
- p.Leu117Val Single submitter ⚠
- p.Phe146Ser Single submitter ⚠
- p.Ser111Leu Single submitter ⚠
- p.Ser30Arg Single submitter ⚠
- p.Thr10Ile Single submitter ⚠
- p.Thr11Pro Single submitter ⚠
- p.Thr81Asn Single submitter ⚠
- p.Val102Leu Single submitter ⚠
- p.Val102Met Single submitter ⚠