CMTM8 — 27 ClinVar variants
All ClinVar germline CMTM8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
27 Uncertain significance
Full CMTM8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CMTM8 p.Ala20Pro Uncertain significance Single submitter
- CMTM8 p.Ala69Ser Uncertain significance Single submitter
- CMTM8 p.Ala7Thr Uncertain significance Single submitter
- CMTM8 p.Arg168Lys Uncertain significance Single submitter
- CMTM8 p.Arg34Gln Uncertain significance Single submitter
- CMTM8 p.Arg66Gln Uncertain significance Single submitter
- CMTM8 p.Asn138Ser Uncertain significance Single submitter
- CMTM8 p.Gly42Ser Uncertain significance Single submitter
- CMTM8 p.Ile172Met Uncertain significance Single submitter
- CMTM8 p.Leu40Pro Uncertain significance Single submitter
- CMTM8 p.Pro4Arg Uncertain significance Single submitter
- CMTM8 p.Ser131Phe Uncertain significance Single submitter
- CMTM8 p.Ser146Leu Uncertain significance Single submitter
- CMTM8 p.Ser169Tyr Uncertain significance Single submitter
- CMTM8 p.Ser28Asn Uncertain significance Single submitter
- CMTM8 p.Ser9Leu Uncertain significance Single submitter
- CMTM8 p.Thr57Met Uncertain significance Single submitter
- CMTM8 p.Tyr119Asn Uncertain significance Single submitter
- CMTM8 p.Tyr96Cys Uncertain significance Single submitter
- CMTM8 p.Val117Ile Uncertain significance Single submitter
- CMTM8 p.Val130Ile Uncertain significance Single submitter
- CMTM8 p.Val78Ile Uncertain significance Single submitter
- CMTM8 p.Val85Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CMTM8 variants
Uncertain significance 27
- p.Ala127Ser Single submitter ⚠
- p.Ala157Ser Single submitter ⚠
- p.Ala20Pro Single submitter ⚠
- p.Ala69Ser Single submitter ⚠
- p.Ala7Thr Single submitter ⚠
- p.Arg168Lys Single submitter ⚠
- p.Arg34Gln Single submitter ⚠
- p.Arg66Gln Single submitter ⚠
- p.Asn138Ser Single submitter ⚠
- p.Asp126Gly Single submitter ⚠
- p.Gly42Ser Single submitter ⚠
- p.Ile172Met Single submitter ⚠
- p.Leu40Pro Single submitter ⚠
- p.Phe36Ser Single submitter ⚠
- p.Pro4Arg Single submitter ⚠
- p.Ser131Phe Single submitter ⚠
- p.Ser146Leu Single submitter ⚠
- p.Ser169Tyr Single submitter ⚠
- p.Ser28Asn Single submitter ⚠
- p.Ser9Leu Single submitter ⚠
- p.Thr57Met Single submitter ⚠
- p.Tyr119Asn Single submitter ⚠
- p.Tyr96Cys Single submitter ⚠
- p.Val117Ile Single submitter ⚠
- p.Val130Ile Single submitter ⚠
- p.Val78Ile Single submitter ⚠
- p.Val85Ile Single submitter ⚠